An observational study in COVID-19 Pneumonia, Sepsis and SARS-CoV-2 Acute Respiratory Disease, sponsored by Osijek University Hospital. Recruiting at 1 site in Croatia. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2024-09-19.
Sponsored by Osijek University Hospital · Observational
The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.
The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission date, intubation date, mechanical ventilation, extubation, discharge, and patient final outcome will be recorded for each patient. By analyzing X-rays of the lungs by radiology specialists, inflammatory infiltrates in the lungs will be quantified via the Brixia system, during hospital admission, admission to the Respiratory Center, and during treatment at the Respiratory Center. All patients will have their Sequential Organ Failure Assessment (SOFA) and/or Acute Physiology and Chronic Health Evaluation (APACHE II) values calculated upon admission. Inflammatory parameters (c-reactive protein (CRP), procalcitonin (PCT), interleukine-6 (IL-6), ferritin), red blood cell count, leukocytes, blood urea nitrogen (BUN), arterial blood gases and ventilation parameters on admission to the hospital, admission to the ICU, and on several occasions during treatment in the ICU will be analysed. Also, empirical use of antibiotics, the occurrence of bacterial superinfections, sepsis and organic failure will be noted.
2,416 studies on the registry are indexed under Sepsis; 541 are open to participants now.
This study's planned enrollment of 200 is above the median of 150 across 1,162 observational studies indexed under Sepsis.
Browse Sepsis studies →Osijek University Hospital is the lead sponsor of 30 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All patients treated in ICU COVID-19 with a diagnosis of pneumonia will be analyzed retrospectively.
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Exclusion Criteria:
Patients treated at the University Hospital Osijek Respiratory Center with pneumonia caused by SARS-CoV-2
Diagnostic Test: Chest X-ray
Retrospective analysis of chest x-rays of patients with COVID-19
Chest x-ray severity score
The influence of the dynamics of radiographic changes quantified by Brixia score on the outcome of COVID-19 patients will be examined
Time frame: 21 days
Inflammatory markers
The influence of serum levels of inflammatory parameters, and clinical and laboratory indicators of organic failure on chest x-ray severity score will be examined
Time frame: 21 days
Started Jan 2020 (actual). Primary completion is estimated for May 2025, 64 months after the start.
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Osijek University Hospital