An observational study in Septic Shock, Multiple Organ Failure and Fatal Outcome, sponsored by Mahidol University. Recruiting at 1 site in Thailand. Open to participants aged 19 Years to 90 Years. Per ClinicalTrials.gov, last updated 2023-10-31.
Sponsored by Mahidol University · Observational
Severe sepsis/septic shock are serious complications of infection with high morbidity and mortality. Recent information showed that early and aggressive resuscitation may help improving survival and outcome especially the resuscitation within the first 3 hours. In surgical patients, either severe sepsis/septic shock bought them to the operating room or this sepsis might be found after surgery resulting in higher morbidity and mortality. Not only knowledge management, others possible risk factors should also be identified and corrected for outcome improving. This prospective observational study will be done in 800 adult surgical patients admitting to the general surgical intensive care unit. Incidence of severe sepsis/septic shock on admission along with risk factors associated with poor outcomes [organ failure (AKI, ALI, PMI, liver failure, stroke), prolonged ICU length of, stay, ICU death] will be recorded especially effect of amount and type of fluid replacement in the first 6 hours, 24, 48 and 72 hours after diagnosis. Outcome as major organ failure, ICU length of stay, ICU, 28 and 90 days mortality will also be study.
Consecutive severe sepsis/ septic shock patients who will be admitted to the general surgical ICU of Siriraj Hospital, Mahidol University, Bangkok, Thailand will be recruited to this study. Apart from demographic data (age, sex, BMI, comorbidity), detail of septic shock and resuscitation (preoperative and intraoperative resuscitation), vasopressor and steroid used, type and amount of fluid, blood and blood component used and shock reversal time. Complication associated with surgery, anesthesia and in ICU will also recorded. Clinical outcome as organ failure (Stroke, PMI, aki, ARDS); ventilator day, ICU and hospital length of stay, mortality (in ICU, 28 and 90 days mortality) and cause of mortality will be carefully recorded
1,078 studies on the registry are indexed under Shock, Septic; 232 are open to participants now.
This study's planned enrollment of 800 is above the median of 108 across 406 observational studies indexed under Shock, Septic.
Browse Shock, Septic studies →Mahidol University is the lead sponsor of 747 studies on the registry; 119 are open to participants now.
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Adult surgical patient admiitiing to the general surgical ICU
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Exclusion Criteria:
severe sepsis/septic shock, organ failure, ICU death
incidence of severe sepsis/septic shock on admission to the general surgical ICU
Incidence of severe sepsis and septic shock on admission to the general surgical ICU
Time frame: 5 year
risk factors associated with poor outcome (organ failure, prolonged ICU length of stay and ICU death)
organ failure (Stroke, AKI, PMI,ARDS), Mortality (ICU, 28 and 90 days) mortality and cause of mortality
Time frame: 5 year
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