An observational study in Heat Stroke, Early Waking and MODS, sponsored by Xijing Hospital. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-08-14.
Sponsored by Xijing Hospital · Observational
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.
The project intends to collect the peripheral blood of the normal population, the 24 hours after the onset of heat stroke and the patients in the recovery period, to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to search for indicators related to disease deterioration and prognosis, construct and verify the early warning and prognosis evaluation system of the disease.
On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of heat stroke, and then clarify the treatment target of heat stroke.
21 studies on the registry are indexed under Heat Stroke; 10 are open to participants now.
Browse Heat Stroke studies →Xijing Hospital is the lead sponsor of 474 studies on the registry; 159 are open to participants now.
Counted across the registry records on this site, refreshed daily.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Healthy volunteers
Diagnostic Test: Peripheral blood test
Patients within 24 hours after onset
Diagnostic Test: Peripheral blood test
Organ dysfunction was corrected, The patient had no obvious discomfort.
Diagnostic Test: Peripheral blood test
Collect peripheral blood to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis
Prognosis
Rate of Surviving or Died Participants with Heat Stroke
Time frame: Day 30 and Day 90
Heat Stroke-associated kindey injury
Concentration of Creatinine(Cr)\>2 mg/dl or Urine output \< 500ml/Day
Time frame: Day 0, Day 7 and On the day of discharge after improvement
Heat Stroke-associated liver injury
Concentration of ALT or AST \>80 U/L, Concentration of TBIL\>2mg/dl（34μmol/l）
Time frame: Day 0, Day 7 and On the day of discharge after improvement
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Aug 2025; primary completion for Jun 2027, 21 months later.
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This study is not yet recruiting, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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