An observational study in Sepsis, Severe Sepsis and Septic Shock, sponsored by The University of Texas Health Science Center, Houston. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-11.
Sponsored by The University of Texas Health Science Center, Houston · Observational
This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.
The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.
The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation.
Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.
1,078 studies on the registry are indexed under Shock, Septic; 232 are open to participants now.
This study's planned enrollment of 30 is below the median of 108 across 406 observational studies indexed under Shock, Septic.
Browse Shock, Septic studies →The University of Texas Health Science Center, Houston is the lead sponsor of 897 studies on the registry; 214 are open to participants now.
Of its 173 completed or terminated interventional studies of FDA-regulated products, 142 (82%) have results posted.
Compared within Shock, Septic, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Sepsis. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Adult patients admitted to medical intensive care unit with severe sepsis or septic shock requiring mechanical ventilation.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Alveolar dead space on mechanically ventilated patients with severe sepsis or septic shock.
Multi-organ failure
Multi-oran failure will be accessed by daily laboratory data, heart function by echocardiogram if available, urinary output, vitals and use of vasopressors.
Time frame: daily for 48 hours then weekly for 2 weeks.
Mortality
All the patient will be followed up to 28-days to determine survival.
Time frame: ICU mortality
This study is not yet recruiting, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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The University of Texas Health Science Center, Houston →