An interventional study of Intermittent enteral nutrition in Intermittent Fasting, Septic Shock and Organ Failure, Multiple, sponsored by University Hospital, Rouen. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-06.
Sponsored by University Hospital, Rouen · Not applicable, Interventional, and Supportive care
This study aims to evaluate the efficiency of intermittent enteral nutrition versus continuous enteral nutrition to prevent from organ failures for patients at the acute phase of sepsis shock with mechanical ventilation in ICU.
Some pre-clinical and observational studies have suggested that intermittent fasting may have a positive impact on patients in ICU by increasing protein synthesis, sensibility to insulin, cetogenesis, autophagy by respecting the circadian rhythm. This study aims to evaluate the impact on organ failures of an intermittent enteral nutrition versus continuous enteral nutrition in patients at the acute phase of sepsis shock with mechanical ventilation in the ICU.
333 studies on the registry are indexed under Intermittent Fasting; 99 are open to participants now.
This study's enrollment of 174 is above the median of 50 across 320 interventional studies indexed under Intermittent Fasting.
Browse Intermittent Fasting studies →University Hospital, Rouen is the lead sponsor of 418 studies on the registry; 106 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Postmenopausal
Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
patients that receive intermittent enteral nutrition.
Other: Intermittent enteral nutrition
patients that receive continuous enteral nutrition
Patients will receive intermittent enteral nutrition, defined as 3 60-minute administrations every 8 hours.
Evolution of variation of the SOFA (Sepsis-related organ failure assessment) score.
Comparison of variation of the SOFA score between patients with intermittent nutrition versus patients with continuous nutrition.
Time frame: day-1 (nutrition start) and day-7
evaluation of caloric intake
evaluation of caloric intake (kcal/day)
Time frame: from day-1 (nutrition start) to day-7
evaluation of protein intake
evaluation of protein intake (g/kg/day)
Time frame: from day-1 (nutrition start) to day-7
Measurement of nutritionnal status
measurement of weight (kg)
Time frame: day-1 (nutrition start) and day-7
Evaluation of the digestive tolerance
Number of vomit (number)
Time frame: from day-1 (nutrition start) to day-7
Evaluation of the nosocomial infections
Type of infection
Time frame: from day-1 (nutrition start) to day-7
Adverse events
Number of adverse event
Time frame: from day-1 (nutrition start) to day-7
Evaluation of the metabolic response
metabolomics analysis (96 proteins assay)
Time frame: day 1, day 4 and day 7
Evaluation of the duration of hospitalisation
number of days at hospital
Time frame: day 1 to day 90
Evaluation of the intensive care neuromuscular weakness
MRC score
Time frame: Up to day 10
Evaluation of death
Death data collection
Time frame: from day 1 to day 90
Evaluation of quality of life
SF-36 score
Time frame: up to day 90
Plan to share: Undecided
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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