Mental Fatigue clinical trials
The registry lists 175 studies for Mental Fatigue across more than 10 countries. 54 are recruiting or about to start. 93 of them are mainly about Mental Fatigue (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04. Counting its narrower condition Compassion Fatigue too: 235 studies, 75 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Vrije Universiteit Brussel (10) · Lincoln University College (5) · Nanyang Technological University (5) · Bandırma Onyedi Eylül University (4) · Vastra Gotaland Region (4) · PepsiCo Global R&D (3) · Inonu University (3) · Francisco Javier Martínez Noguera (2)
What is being tested here
Drugs under test in Mental Fatigue studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Effects of Cognitive Fatigue on Gait · State University of New York at Buffalo
- Nov 2026Effects of Hemp-Derived Cannabinoids on Menopause Symptoms · Washington State University
- Dec 2026Long COVID Brain Fog: Cognitive Rehabilitation Trial · University of Alabama at Birmingham
- Dec 2026Pain & Reward Neuromodulation of CNS Circuits · Duke University
- Dec 2026Predicting Declines in Attention and Memory During a Prolonged Mental Task · DSW Ideis University
- Dec 2026A Clinical Trial to Evaluate the Effects of the Edge+Ease PM+AM System on Mood, Mental Clarity, Sleep Quality, and Digestive Wellbeing · Edge+Ease
- Dec 2026Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog · Mayo Clinic
- Dec 2026A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental Clarity · Ancestral Supplements, LLC
- Dec 2026Sleep, Mental Fatigue, and Performance in Students · L.U.de.S. Sagl
- Dec 2026Water-based Activity to Enhance Recovery in Long COVID-19 · VA Office of Research and Development
Who these studies take
Of the 29 Mental Fatigue studies recruiting now, 9 (31%) set no upper age limit and 19 (66%) stop at 75 or younger. 1 (3%) take children under 18. 3 (10%) are for women only and 1 (3%) for men only; 15 (52%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (3%) | 1 (3%) |
| 18 | 23 (79%) | 23 (79%) |
| 30 | 26 (90%) | 26 (90%) |
| 40 | 26 (90%) | 24 (83%) |
| 50 | 26 (90%) | 23 (79%) |
| 65 | 20 (69%) | 19 (66%) |
| 75 | 11 (38%) | 11 (38%) |
| 85 | 10 (34%) | 10 (34%) |
Across all 175 studies, recruiting or not: 70% stop at 75 or younger and 62% at 65; 7% take children; 10% are for women only and 10% for men only; 59% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Mental Fatigue studies take
Of 92 interventional studies with no phase under Mental Fatigue, half reached primary completion within 8 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 8 mo3–23 · 92 studies | — | 9 mo3–23 · 80 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Newly registered3
- A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental ClarityOct 23, 2026NCT07892911
- Intensive Home-based Transcranial Direct Current Stimulation for Long COVIDOct 19, 2026NCT07880171
- Predicting Declines in Attention and Memory During a Prolonged Mental TaskOct 16, 2026NCT07877389
Studies
Recruiting first, then most recently updated. Showing 50 of 175. Browse all 175 → or search them.
- COG+OT Telerehabilitation for Adults With Subjective Cognitive ComplaintsNot yet recruitingNCT07743229Not applicable1 country
- ME/CFS Brain Fog: Cognitive Rehabilitation TrialRecruitingNCT07523113Not applicable1 country
- Virtual Reality - Gamma Sensory Stimulation for Improving Fatigue in People With Multiple SclerosisRecruitingNCT07310862Not applicable1 country
- Predicting Declines in Attention and Memory During a Prolonged Mental TaskNot yet recruitingNCT07877389Not applicable1 country
- Guanfacine and Cromolyn Sodium for POTS: The DBPOTS TrialNot yet recruitingNCT07757555Early Phase 11 country
- Effects of Caffeine on Chess Performance and Cognitive Function in Professional Chess PlayersRecruitingNCT07641335Not applicable1 country
- Acute Mental Fatigue and Muscle StrengthRecruitingNCT07846618Not applicable1 country
- Effects of a Mobile Game in Menopausal WomenNot yet recruitingNCT07800793Not applicable1 country
- Validating Immunological Markers Associated With Mental Fatigue in Graves' DiseaseRecruitingNCT060814391 country
- Sleep, Mental Fatigue, and Performance in StudentsRecruitingNCT076446111 country
- Effects of Laughter Yoga in the Third TrimesterEnrolling by invitationNCT07794371Not applicable1 country
- Mental Fatigue, Attentional Focus, and Countermovement Jump PerformanceNot yet recruitingNCT07779304Not applicable1 country
- Monitoring the Effect of Mental Fatigue on Physical Performance Using Wearable Sensors and Physiological ParametersRecruitingNCT07323810Not applicable1 country
- The Effect of Brain Endurance Training on Motor Skill Learning in Adolescents With Mild Mental FatigueNot yet recruitingNCT07746557Not applicable
- Pain & Reward Neuromodulation of CNS CircuitsEnrolling by invitationNCT07525063Not applicable1 country
- The Effects of Caffeine and Vitamin C on Maximum Strength and Strength Endurance in Adolescents With Mild Mental FatigueNot yet recruitingNCT07726745Not applicable
- A Clinical Trial to Evaluate the Effects of the Edge+Ease PM+AM System on Mood, Mental Clarity, Sleep Quality, and Digestive WellbeingNot yet recruitingNCT07721506Not applicable
- Transcranial Direct Current Stimulation for Long COVID Brain Fog and FatigueNot yet recruitingNCT07709234Not applicable
- Effects of Cognitive Fatigue on GaitNot yet recruitingNCT07710755Not applicable
- CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of LifeRecruitingNCT076790741 country
- Water-based Activity to Enhance Recovery in Long COVID-19RecruitingNCT06142253Not applicable1 country
- Mental Fatigue Effects on Posture and Spinal ReflexesNot yet recruitingNCT07650903Not applicable1 country
- The Effect of Mental Fatigue on Upper Extremity Functional PerformanceNot yet recruitingNCT07645404Not applicable1 country
- Cognitive Task Sensitivity in Perimenopause and Nutritional StatusNot yet recruitingNCT076486671 country
- Using Digital Health Technology to Monitor Patients With Primary Biliary Cholangitis (PBC)Enrolling by invitationNCT076314421 country
- Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain FogRecruitingNCT06614309Not applicable1 country
- Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVIDRecruitingNCT07627815Phase 21 country
- Sildenafil to Prevent and Reduce Cancer Related Cognitive ImpairmentNot yet recruitingNCT06800092Phase 2/31 country
- NC Testing in LC & POTSRecruitingNCT05914649Not applicable1 country
- Transcranial Direct Current Stimulation for Post Treatment Lyme DiseaseRecruitingNCT06915324Not applicable1 country
- The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer SurvivorsRecruitingNCT06938555Not applicable1 country
- Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care PatientsNot yet recruitingNCT07545928Not applicable1 country
- Effects of Hemp-Derived Cannabinoids on Menopause SymptomsRecruitingNCT07393672Phase 21 country
- A Study to Evaluate the Effects of a Supplement on the Side Effects Associated With Stimulant MedicationsRecruitingNCT07380412Not applicable1 country
- Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation ResearchRecruitingNCT048066201 country
- Effects of Vitamin B12 and Natural Orange Extract, and Their Combination on Physical and Mental PerformanceEnrolling by invitationNCT07341789Not applicable1 country
- Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.RecruitingNCT07319117Not applicable1 country
- Modulation of the Brain Fog Scale by Eicosapentaenoic Acid Monoglycerides (MAG-EPA).RecruitingNCT06695910Phase 41 country
- Observational Study of Intranasal IVIG in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients Undergoing Medical TourismNot yet recruitingNCT06992401
- Course for Brain Fatigue After Graves' Disease Controlled StudyRecruitingNCT06134219Not applicable1 country
- The Impact of Person Centred Care (PCC) in Grave's DiseaseRecruitingNCT06309316Not applicable1 country
- Transcranial Ultrasound Stimulation for Cognitive Function Modulation in Patients With Post COVID-19 Brain FogRecruitingNCT07154199Not applicable1 country
- Brain Fog in Sleep ApneaRecruitingNCT066644501 country
- Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain InjuryRecruitingNCT071357911 country
- Music Intervention on Golfers Under Mental FatigueNot yet recruitingNCT06952283Not applicable1 country
- Investigating Health Impacts of Exposure to Harmful Algal BloomsRecruitingNCT068832271 country
- Effect of a New Formulation of Vitamin B12 on Physical and MentalRecruitingNCT06639789Not applicable1 country
- Effects of Oral Nicotine and Caffeine Pouches on Anaerobic Performance, Autonomic Function, Cognition, and BehaviorEnrolling by invitationNCT06529055Not applicable1 country
- Body Awareness and Mental Fatigue in Neck PainNot yet recruitingNCT064346881 country
- Neural and Cognitive Consequences of COVID-19 SurvivalRecruitingNCT062089431 country