An observational study in COVID Long-Haul, COVID-19 and COVID-19 Pandemic, sponsored by San Francisco Veterans Affairs Medical Center. Recruiting at 1 site in United States. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-12.
Sponsored by San Francisco Veterans Affairs Medical Center · Observational
The novel coronavirus SARS-CoV-2 infection, COVID, continues to rage throughout the world with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). This translates to millions of people surviving COVID19 infection. While the lungs are ground zero, COVID tears through organ systems from brain to blood vessels. We are now beginning to see people recover but complain of ongoing problems, including lingering cognitive problems, depression, and anxiety. We have brought together 2 laboratories with complementary techniques including psychological testing and neuroimaging methods togethers with markers in the blood that may signal damage in the brain. A close look at these problems is timely and imperative if we are to understand the pathophysiology of 'COVID brain' and prepare for downstream problems.
The SARS-CoV-2 pandemic has been going on for over a year worldwide, with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). We are seeing people recover from the initial COVID infection with complaints of ongoing problems. An increasing number of people are complaining of cognitive deficits and depression/anxiety.
Methodologically, we have brought together two laboratories studying neurocognitive impairment using an EEG, MRI, and behavioral approach as well as laboratory-based data. This study queries neuropsychological functions in individuals using a neuropsychological battery, EEG-based measures, functional MRI (connectivity) and structural MRI (gray and white matter volumes, myelin, micro-bleeds). In addition, we have preliminary data to show a continued increase in plasma cytokines in COVID survivors. Plasma isolated neuronal enriched extracellular vesicles (nEVs) showed an increase in amyloid beta, neurofilament light and pT181-Tau, all proteins associated with neurodegeneration.
The overall aim is to determine the extent of cognitive, clinical, and neurological damage in people recovered from COVID.
Individuals 18-70 years old who were diagnosed with COVID-19 at least 3 months ago.
Exclusion Criteria:
Individuals (ages 18-70 years) who endorse a reported change in concentration, memory, feelings anxiety or depression since initial COVID infection.
Other: cross-sectional MRI and EEG assessments (NO INTERVENTION)
Individuals (ages 18-70 years) who do not feel any different since recovering from initial COVID infection.
Other: cross-sectional MRI and EEG assessments (NO INTERVENTION)
n/a there is no intervention in this observational study
Also known as: cross-sectional MRI and EEG assessments
Change of Neuropsychological Test Performance
We will compare NP test performance in people with Covid-related worsening of attention, memory, anxiety, and/or depression to people who do not endorse worsening in those domains.
Time frame: 1 month
Number of Participants with EEG Latency & Amplitude
We will compare EEG-derived event related potential measures of neural speed in people with Covid-related worsening of attention, memory, anxiety, and/or depression to people who do not endorse worsening in those domains.
Time frame: 1 month
Number of Participants with MRI Functional Disconnectivity
We will compare thalamo-cortical connectivity in people with Covid-related worsening of attention, memory, anxiety, and/or depression to people who do not endorse worsening in those domains.
Time frame: 1 month
Number of Participants with Blood Biomarkers
We will correlate blood biomarkers of inflammation and NP test performance, thalamo-cortical connectivity, and measures of neural speed.
Time frame: 1 month
Plan to share: No — Not part of currently approved protocol or original agreement with sponsor.
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San Francisco Veterans Affairs Medical Center