An interventional study of Menopause Mobile Game in Menopause, Brain Fog and Psychological Well-being, sponsored by Medipol University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to female participants aged 45 Years to 55 Years. Per ClinicalTrials.gov, last updated 2026-09-17.
Sponsored by Medipol University · Not applicable, Interventional, and Health services research
The goal of this clinical trial is to evaluate the effect of a mobile game-based cognitive intervention on brain fog and psychological well-being in menopausal women aged 45-55 years. The main questions it aims to answer are:
Are Brain Fog Scale scores lower among women in the mobile game intervention group compared with women in the control group? Are Warwick-Edinburgh Mental Well-Being Scale scores higher among women in the mobile game intervention group compared with women in the control group? Do women participating in the mobile game intervention demonstrate greater reductions in Brain Fog Scale scores and greater improvements in Warwick-Edinburgh Mental Well-Being Scale scores after the intervention compared with their baseline measurements?
Researchers will compare participants receiving the mobile game-based cognitive intervention with participants receiving routine follow-up only to determine the effectiveness of the intervention on brain fog and psychological well-being.
Participants will:
Complete baseline assessments using the Brain Fog Scale and the Warwick-Edinburgh Mental Well-Being Scale.
Be randomly assigned to either the intervention group or the control group. Use the cognitive training mobile game for 15 minutes per day, 5 days per week, for 6 weeks if assigned to the intervention group.
Receive routine follow-up only if assigned to the control group. Complete post-intervention assessments at the end of the 6-week study period.
Menopause is a natural stage in a woman's life characterized by hormonal changes that may affect physical, psychological, and cognitive health. In addition to vasomotor symptoms, many women report cognitive difficulties during the menopausal transition, commonly referred to as "brain fog." Brain fog encompasses subjective experiences such as reduced concentration, forgetfulness, slower information processing, and difficulties in maintaining attention. These cognitive challenges may negatively influence daily functioning, work productivity, self-confidence, and overall quality of life.
Psychological well-being is another important aspect of women's health during menopause. Hormonal fluctuations, aging-related changes, and psychosocial factors may contribute to declines in well-being. Cognitive difficulties and psychological well-being are closely interrelated, as persistent cognitive concerns may increase emotional distress and negatively affect individuals' perceptions of their mental health and well-being.
Digital health interventions have gained increasing attention as accessible and scalable approaches for supporting health promotion and symptom management. Among these interventions, mobile games offer opportunities to engage users through interactive and motivating activities while facilitating learning and cognitive stimulation. Cognitive training exercises delivered through mobile games may support cognitive functions such as attention, working memory, cognitive flexibility, verbal fluency, and visual memory. However, evidence regarding the effectiveness of mobile game-based cognitive interventions specifically designed for menopausal women remains limited.
The mobile game used in this study was developed to provide cognitive training through gamified activities targeting multiple cognitive domains. The intervention incorporates structured exercises intended to support attention, memory, problem-solving, and cognitive flexibility while promoting sustained engagement through an interactive digital format.
This study will investigate whether participation in a mobile game-based cognitive intervention can improve cognitive functioning related to brain fog and enhance psychological well-being among menopausal women. The findings are expected to contribute to the growing evidence base on non-pharmacological digital interventions and may support the development of accessible, low-cost, and sustainable approaches for promoting cognitive and psychological health during menopause.
175 studies on the registry are indexed under Mental Fatigue; 54 are open to participants now.
This study's planned enrollment of 82 is above the median of 45 across 143 interventional studies indexed under Mental Fatigue.
Browse Mental Fatigue studies →Medipol University is the lead sponsor of 326 studies on the registry; 88 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will use a mobile game developed to address brain fog symptoms during menopause.
Behavioral: Menopause Mobile Game
Participants will receive routine care and will not use the mobile game during the study period.
Participants in the intervention group will use a mobile game specifically designed for menopausal women to support cognitive functioning. The game includes interactive exercises and activities targeting attention, memory, processing speed, and other cognitive skills. Participants will use the mobile game throughout the intervention period in addition to routine care.
Also known as: Menopause Education and Self-Management Mobile Game
Brain fog
Change in Brain Fog Scale total score from baseline to post-intervention. The Brain Fog Scale is a 30-item instrument assessing cognitive, physical, and psychological symptoms of brain fog. Total scores range from 30 to 150, with higher scores indicating greater brain fog severity (worse outcome).
Time frame: Baseline and Week 6
Change in Warwick-Edinburgh Mental Well-Being
The effect of the mobile game intervention on psychological well-being among menopausal women will be assessed using the Warwick-Edinburgh Mental Well-Being Scale. Total scores range from 14 to 70, with higher scores indicating better mental well-being. Changes in total scores from baseline to Week 6 will be evaluated.
Time frame: Baseline and Week 6
Plan to share: No — Individual participant data (IPD) will not be publicly shared because the study involves sensitive health-related information collected from participants. Data will be used solely for the purposes of this research and will be reported in aggregate form to protect participant confidentiality.
No publications or documents are linked to this record.
Start is estimated for Oct 2026; primary completion for Sep 2027, 11 months later.
Of 80 non-industry interventional studies with no phase under Mental Fatigue, half reached primary completion within 9 months of starting (the median), counting those still running; a quarter within 3 and three quarters within 23. This study's planned 11 months is above that.
Counting every sponsor, half of 92 studies reached it within 8 months; a quarter within 3 and three quarters within 23.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.