Drug
Trospium chloride clinical trials
A product of Trospium; its studies count on that page too.
- studies test it
- 27
- open now
- 9
- in phase 3
- 12
- first study started
- 2009
Keep track of what changes. Save the trospium chloride studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Development codes
Studies by the year they started
27 studies that test it; most in 2025 (6)
| Year | Studies |
|---|---|
| 2009 | 3 |
| 2010 | 2 |
| 2013 | 1 |
| 2016 | 1 |
| 2018 | 1 |
| 2020 | 2 |
| 2021 | 4 |
| 2022 | 2 |
| 2023 | 1 |
| 2025 | 6 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 5
- Phase 2
- 2
- Phase 3
- 12
- Phase 4
- 8
- No phase
- 1
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 23 · Other 4
Karuna Therapeutics, Inc., a Bristol Myers Squibb company (7) · Karuna Therapeutics (6) · Allergan (5) · Bristol-Myers Squibb (5) · University of North Carolina, Chapel Hill (1) · Collaborative Neuroscience Research, LLC (1) · New York State Psychiatric Institute (1) · Mansoura University (1)
Often tested with
Tested in the same studies.
Studies
Open first, then newest update. How each study uses trospium chloride is read from its arms, and is right about nine times in ten.
Testing it · 27
- A Study to Evaluate the Effect of KarXT on Urological SafetyRecruitingPhase 4Bristol-Myers SquibbNCT07221877Written as Xanomeline/trospium chloride
- A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)RecruitingPhase 3Bristol-Myers SquibbNCT07011732Written as Xanomeline/Trospium Chloride Capsule
- A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult ParticipantsRecruitingPhase 1Karuna Therapeutics, Inc., a Bristol Myers Squibb companyNCT07204418Written as Xanomeline/ Trospium Chloride
- A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's DiseaseRecruitingPhase 3Bristol-Myers SquibbNCT07011745Written as Xanomeline/Trospium Chloride Capsule
- Relapse Prevention Trial Evaluating KarXT Treatment in SchizophreniaRecruitingPhase 3Karuna Therapeutics, Inc., a Bristol Myers Squibb companyNCT07686263Written as Xanomeline/Trospium Chloride
- A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, Explore the Effect of Food After Multiple Doses of Selected Prototypes, and Evaluate Alternative Formulations of KarX and KarXT Following Single and Multiple Ascending DosesRecruitingPhase 1Bristol-Myers SquibbNCT07063342Written as Xanomeline/Trospium Chloride Capsule
- A PET/MRI Study of Cobenfy on Dopamine Transmission in SchizophreniaRecruitingPhase 1/2New York State Psychiatric InstituteNCT07423546Written as Xanomeline and trospium chloride (KarXT)
- A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or LamotrigineRecruitingPhase 3Bristol-Myers SquibbNCT07140913Written as Xanomeline/Trospium Chloride
- An 8-week Open-label Study of an Accelerated and Slower Switching to Xanomeline/Trospium Following Atypical Antipsychotic Treatment in Participants With SchizophreniaNot yet recruitingPhase 4Collaborative Neuroscience Research, LLCNCT06924255Written as Xanomeline and Trospium Chloride
- An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of SchizophreniaCompletedPhase 3Karuna Therapeutics, Inc., a Bristol Myers Squibb companyNCT05304767Written as Xanomeline and Trospium Chloride Capsules
- KarXT Concentrations in the Breast Milk and Plasma of Lactating FemalesCompletedPhase 4Karuna Therapeutics, Inc., a Bristol Myers Squibb companyNCT07257120Written as Xanomeline/trospium chloride
- A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of SchizophreniaCompletedPhase 3Karuna Therapeutics, Inc., a Bristol Myers Squibb companyNCT05145413Written as Xanomeline and Trospium Chloride Capsules
- A Study to Assess the Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Chinese Adult Subjects With DSM-5 SchizophreniaCompletedPhase 3Karuna Therapeutics, Inc., a Bristol Myers Squibb companyNCT05919823Written as Xanomeline and Trospium Chloride Capsules
- An Open-label Study to Assess the Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-5)CompletedPhase 3Karuna Therapeutics, Inc., a Bristol Myers Squibb companyNCT04820309Written as Xanomeline and Trospium Chloride Capsules
- A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-3)CompletedPhase 3Karuna TherapeuticsNCT04738123Written as Xanomeline and Trospium Chloride Capsules
- An Extension Study to Assess Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-4)CompletedPhase 3Karuna TherapeuticsNCT04659174Written as Xanomeline and Trospium Chloride Capsules
- An Open-label Study to Assess the Long-term Safety, Tolerability, Effectiveness, and Durability of Effect of KarXT in Patients With DSM-5 Diagnosis of SchizophreniaTerminatedPhase 3Karuna TherapeuticsNCT05643170Written as Xanomeline and Trospium Chloride Capsules
- A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-2)CompletedPhase 3Karuna TherapeuticsNCT04659161Written as Xanomeline and Trospium Chloride Capsules
- Trospium Chloride vs Tamsulosin in Treatment of Ureteral Stent Related Symptoms:SuspendedNot applicableMansoura UniversityNCT03709992Written as Trospium Chloride
- A Study to Assess Safety and Efficacy of KarXT in Adult Patients With SchizophreniaCompletedPhase 2Karuna TherapeuticsNCT03697252Written as Xanomeline and Trospium Chloride Capsules
See all 27 studies that test trospium chloride →
Given in every arm · 1 — trospium chloride is usual care beside what is tested
As the comparator · 2 — what is tested is compared with trospium chloride
- Comparative Effectiveness of Initial OAB Treatment Options Among Older Women at High Risk of FallsCompletedEarly Phase 1The University of Texas Medical Branch, GalvestonNCT05880862Written as Trospium Chloride
- Anticholinergic vs. Botox Comparison StudyCompletedPhase 3NICHD Pelvic Floor Disorders NetworkNCT01166438Written as Trospium chloride
Codes
What other systems call trospium chloride · ClinicalTrials.gg INT002272
- MeSH (NLM) C003330trospium chlorideConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 1E6682427ETROSPIUM CHLORIDEConfirmed FDA, NLM, Wikidata
- RxNorm 38891Confirmed FDA, Wikidata
- Wikidata Q27252312trospium chlorideConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61995Trospium ChlorideOne source FDA
- DrugBank DBSALT000883One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C003330 | trospium chloride | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 1E6682427E | TROSPIUM CHLORIDE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 38891 | — | Confirmed FDA, Wikidata |
| Wikidata | Q27252312 | trospium chloride | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61995 | Trospium Chloride | One source FDA |
| DrugBank | DBSALT000883 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.