An interventional study of Research interview in Manic Episode and Bipolar I Disorder, sponsored by Mayo Clinic. Completed at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-03-19.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Supportive care
This research is being done to find if there are changes with voice and speech during episodes of mania.
166 studies on the registry are indexed under Mania; 13 are open to participants now.
This study's enrollment of 17 is below the median of 89 across 138 interventional studies indexed under Mania.
Browse Mania studies →Mayo Clinic is the lead sponsor of 3,269 studies on the registry; 672 are open to participants now.
Of its 452 completed or terminated interventional studies of FDA-regulated products, 321 (71%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
While inpatient, participants will undergo a research interview with recorded audio.
Behavioral: Research interview
Research interview to capture speech data with high quality cardioid headset microphone
Acoustic Differences
The raw audio data will be analyzed for change in pitch, variability of rhythm, and response time.
Time frame: Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment
Syntactical Differences
Audio data will be transcribed using voice to text software and then analyzed for syntactical elements of speech including sentence structure and grammar.
Time frame: Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment
Semantic Differences
Transcribed audio data will be analyzed for changes in verbosity, lexical diversity, and coherence on a sentence and paragraph level.
Time frame: Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment
Plan to share: No
Ran from Apr 2023 to primary completion in Sep 2024, 16 months.
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This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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