Malocclusion clinical trials
The registry lists 323 studies for Malocclusion across more than 10 countries. 85 are recruiting or about to start. 263 of them are mainly about Malocclusion (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02. Counting its 4 narrower conditions too, such as Malocclusion, Angle Class II: 533 studies, 124 open.
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Status
Who runs them
Damascus University (16) · Al-Azhar University (14) · Biolux Research Holdings, Inc. (7) · Cairo University (6) · University of Pavia (6) · Alexandria University (5) · Align Technology, Inc. (5) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (5)
What is being tested here
Drugs under test in Malocclusion studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Impact of Anterior Cross Bite Treatment on Children's Speech Performance · Tanta University
- Nov 2026Clear Orthodontic Expander Versus Hyrax · University of Baghdad
- Nov 2026Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy · Hama University
- Nov 2026Patient-Reported Outcomes for Different Orthodontic Thermoplastics Used in Clear Aligners · CMH Lahore Medical College and Institute of Dentistry
- Dec 2026Epidemiological Investigation of Malocclusion in China · Shanghai Jiao Tong University School of Medicine
- Dec 2026A Comparative Study Between Modified Miniscrew-Assisted Rapid Palatal Expander And Modified Rapid Palatal Expander in Molar Distalization Using Cone- Beam Computed Tomography · Al-Azhar University
- Dec 2026Comparison of Maxillary Dental Expansion Using Smartee Clear Aligner With and Without S11 Expander: A Randomized Clinical Trial · Aisha Ali Qahtani
- Dec 2026Periodontal Health in Adults Treated With Fixed Orthodontic Appliances or Clear Aligners · Ravan Mammadov
- Feb 2027Impact of Aligner Replacement Protocols on Predictability of Planned Dental Movements: Evaluation of Double Aligner · Neodent
- Feb 2027Efficacy of Orthodontic Tooth Movement Using Beveled and Conventional Attachments in Aligners · Neodent
Who these studies take
Of the 42 Malocclusion studies recruiting now, 8 (19%) set no upper age limit and 34 (81%) stop at 75 or younger. 33 (79%) take children under 18. 1 (2%) are for women only and 0 (0%) for men only; 18 (43%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 11 (26%) | 10 (24%) |
| 18 | 30 (71%) | 30 (71%) |
| 30 | 24 (57%) | 24 (57%) |
| 40 | 19 (45%) | 19 (45%) |
| 50 | 11 (26%) | 11 (26%) |
| 65 | 11 (26%) | 11 (26%) |
| 75 | 8 (19%) | 8 (19%) |
| 85 | 8 (19%) | 8 (19%) |
Across all 323 studies, recruiting or not: 76% stop at 75 or younger and 74% at 65; 70% take children; 1% are for women only and 0% for men only; 46% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Malocclusion studies take
Of 163 interventional studies with no phase under Malocclusion, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 19 mo10–32 · 163 studies | — | 18 mo10–30 · 153 studies |
| Observational | 25 mo12–46 · 32 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered3
- Timing, Trajectories and Prediction in Severe Dental Crowding: The Create SPACE (cSPACE)Nov 2, 2026NCT07911176
- FM Technique in Orthodontic Clear Aligner Therapy: A Single-Arm Clinical StudyOct 27, 2026NCT07896369
- Evaluation of Corticotomy-Assisted Canine Retraction RateOct 16, 2026NCT07879066
Studies
Recruiting first, then most recently updated. Showing 50 of 323. Browse all 323 → or search them.
- Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine RetractionRecruitingNCT07455656Not applicable1 country
- Timing, Trajectories and Prediction in Severe Dental Crowding: The Create SPACE (cSPACE)Not yet recruitingNCT07911176Not applicable
- FM Technique in Orthodontic Clear Aligner Therapy: A Single-Arm Clinical StudyRecruitingNCT07896369Not applicable1 country
- Evaluation of Corticotomy-Assisted Canine Retraction RateEnrolling by invitationNCT07879066Not applicable1 country
- Comparison of Orthodontic Molar Protraction With and Without Adjunctive SurgeryNot yet recruitingNCT03794726Not applicable
- This RCT Compares the Clinical Performance, Stability, and Patient Perception of Different Diameters Orthodontic Miniscrews in the Posterior Maxilla Buccal Side.Enrolling by invitationNCT07868705Not applicable1 country
- Impact of Anterior Cross Bite Treatment on Children's Speech PerformanceRecruitingNCT06168695Not applicable1 country
- Augmented Reality DentistryNot yet recruitingNCT07814794Not applicable1 country
- Evaluation of the Effects of Orthognathic Surgeries on the Temporomandibular Joint Using a Mandibular Movement Analyzer DeviceRecruitingNCT078280411 country
- Patient-Reported Outcomes for Different Orthodontic Thermoplastics Used in Clear AlignersRecruitingNCT07790315Not applicable1 country
- Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket TherapyRecruitingNCT05684510Not applicable1 country
- Clinical Evaluation of Zirconium Dioxide Nano-Coated Arch WiresNot yet recruitingNCT07813117Not applicable
- Diode Laser Versus LED for Maxillary Canine Retraction in Orthodontic PatientsRecruitingNCT07810699Not applicable1 country
- Maxillary Canine Retraction Using Stainless Steel and Titanium-molybdenum Alloy Wires in TAD-supported Segmental MechanicsEnrolling by invitationNCT07645417Not applicable1 country
- Exploration of the Utility of Dental-dedicated MRI for DentistryRecruitingNCT069481621 country
- Digital vs Conventional VFR in Post-Orthodontic RetentionNot yet recruitingNCT07760935Not applicable
- A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.RecruitingNCT07290790Not applicable3 countries
- 3D Printed Occlusal Splints for Intraoperative UseNot yet recruitingNCT07079111Not applicable
- 3D-Printed vs Conventional Fixed Retainers After Orthodontic TreatmentNot yet recruitingNCT07730476Not applicable
- Changes in Depression and Esthetic Perception After Orthognathic SurgeryRecruitingNCT077024481 country
- Skeletal and Dentoalveolar Effects of Functional Clear Aligner Therapy in Growing Patient With Skeletal Class III MalocclusionEnrolling by invitationNCT07703007Not applicable1 country
- Digital vs. Conventional Indirect Bonding.RecruitingNCT07692880Not applicable1 country
- Optimizing Orthodontic Appliances Efficiency With Remote Dental Monitoring and Artificial Intelligence AlgorithmsRecruitingNCT05573308Not applicable1 country
- Postural Assessment in Patients With MalocclusionsNot yet recruitingNCT07664059
- Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine RetractionNot yet recruitingNCT07658235Not applicable1 country
- Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment AnalysesRecruitingNCT041173601 country
- Comparison of Acupressure, Ibuprofen, and Chewing Gum for the Management of Post-Archwire Orthodontic PainNot yet recruitingNCT07638644Not applicable
- Bromelain for Post-surgery Facial SwellingRecruitingNCT07115212Not applicable1 country
- Gingival Phenotype and Dental Crowding in Pediatric PatientsRecruitingNCT072051721 country
- "Sliding Jigs vs Retraction Hooks for Maxillary Dentition Distalization Using IZC Miniscrews"RecruitingNCT07307209Not applicable1 country
- Evaluation of Clinical and Patient-Reported Outcomes of LacebackRecruitingNCT07039071Not applicable1 country
- Effect on Periodontal Phenotype of Flapless Piezoincission During Orthodontic TreatmentRecruitingNCT06315348Not applicable1 country
- Comparison of Three Orthodontic Separators for Pain, Plaque, and Tooth SeparationNot yet recruitingNCT07532044Not applicable1 country
- 3-D Evaluation of Alveolar Bone Changes and Root Resorption After Traction of Buccally Displaced Maxillary CaninesRecruitingNCT07399197Not applicable1 country
- Research on Deep Learning-Based Intelligent Diagnosis and TreatmentNot yet recruitingNCT07551622
- Clear Orthodontic Expander Versus HyraxRecruitingNCT07362160Not applicable1 country
- Comparison of Maxillary Dental Expansion Using Smartee Clear Aligner With and Without S11 Expander: A Randomized Clinical TrialNot yet recruitingNCT07533682Not applicable1 country
- Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study.Not yet recruitingNCT074764171 country
- Effects of Invisalign Palatal Expander vs Rapid Palatal Expander With Facemask in Growing Class III PatientsNot yet recruitingNCT07485478Not applicable1 country
- Effect of Local Use of Vitamin D on the Rate of Canine Distillization: a Split Mouth Randomized Control TrialRecruitingNCT07479290Phase 11 country
- Evaluation of Emotional Responses Using the I-Motions System and Self-assessment Questionnaires, and Assessment of Postoperative Anatomical and Structural Units (TMJ and Masticatory Muscles) in Orthognathic Surgery PatientsEnrolling by invitationNCT07477873Not applicable1 country
- Accuracy and Periodontal Outcomes of Three Interproximal Enamel Reduction Techniques During Clear Aligner TherapyNot yet recruitingNCT07377825Not applicable1 country
- Management of Skeletal Class III Malocclusion With Digital Bonded Reverse Twin Block in Mixed DentitionEnrolling by invitationNCT07376954Phase 11 country
- Finite Element Modelling of Le Fort I Osteotomy Fixation : PSI vs MiniplatesNot yet recruitingNCT073656571 country
- Validation of AI-Based Cephalometric Analysis in OrthodonticsNot yet recruitingNCT073151521 country
- "Facially Driven Digital Full-Mouth Rehabilitation"RecruitingNCT073140341 country
- Evaluation of the Effect of Adenoid Hypertrophy on the Masseter Muscle in Children: A Comparative Ultrasonographic StudyRecruitingNCT070945811 country
- Effects of Vitamin D in Patients Undergoing Fixed Orthodontic MechanotherapyNot yet recruitingNCT07299552Not applicable1 country
- 3D Analysis of Palatal Morphology of Growing Patients Treated With Rapid Palatal Expander.RecruitingNCT065226071 country
- Evaluation of the Perceived Experience of Patients Treated With Aligners With Two Different TimingsRecruitingNCT06536335Not applicable1 country