An interventional study of Bromelain in Malocclusion, sponsored by Mohamed Bazina. Recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-06-05.
Sponsored by Mohamed Bazina · Not applicable, Interventional, and Supportive care
The goal of this clinical trial is to learn if Bromelain Supplement works to decrease the amount of swelling or the amount of time swelling is present following jaw surgery. It will also learn about the safety of Bromelain supplement. The main questions it aims to answer are:
Does Bromelain decrease facial swelling following orthognathic, or jaw, surgery? Does Bromelain supplement decrease the amount of time that patients are swollen following orthognathic, or jaw, surgery?
Participants will:
Take Bromelain supplement once daily for 9 days total. Take 2 days before surgery and 7 days following surgery.
Keep a log of when the bromelain supplement is taken as well as another other medications.
Visit the clinic with pre and post surgical protocol
323 studies on the registry are indexed under Malocclusion; 85 are open to participants now.
This study's planned enrollment of 200 is above the median of 37 across 242 interventional studies indexed under Malocclusion.
Browse Malocclusion studies →Mohamed Bazina is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
1000mg bromelain supplement once a day, 2 days prior to and 7 days following surgery
Dietary Supplement: Bromelain
Standard of care
1 tablet daily with water, for 9 days-starting 2 days before surgery and continuing for 7 days after. Record each dose in the provided log, along with any other medications taken and the time they were taken.
Also known as: Naturebell
Change in Volume of Swelling
Images will be obtained with the Vectra 3D imaging system to look at the volume of swelling in patients that undergo orthognathic surgery and measured in Cubic Centimeters. Will also have a heat map to visually show where swelling has increased or decreased since previously obtained imaging. All these images and measurements will be compared between the control and experimental groups.
Time frame: Baseline, and post intervention weeks 1, 2, 4, and months 3 and 6
Duration of Swelling following Orthognathic Surgery
Images will be obtained with the Vectra 3D imaging system to look at the volume of swelling in patients that underwent orthognathic surgery at multiple time periods. With comparisons of these multiple photos the duration of swelling can be assessed and compared to the average amount of time it takes swelling to go down in a patient not taking bromelain supplement.
Time frame: Baseline, and post intervention weeks 1, 2, 4, and months 3 and 6
Plan to share: No
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Studies of the drug tested here: Bromelains
Mohamed Bazina