Open Bite clinical trials
The registry lists 34 studies for Open Bite across more than 10 countries. 8 are recruiting or about to start. 33 of them are mainly about Open Bite (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-28.
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Status
Phase
- Phase 3
- 1
Who runs them
Cairo University (6) · Damascus University (4) · Alexandria University (2) · Mansoura University (2) · University Ghent (1) · Sana'a University (1) · University of Dundee (1) · Ankara University (1)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Nov 2026IOA Preventing Occlusal Changes With MAD Use · Isabel Moreno Hay
- Dec 2026Investigate the Effectiveness of 3D-printed Shape Memory Aligners in the Treatment of Anterior Open Bite · Kufa University
- Oct 2027Myofunctional Therapy in Open Bite - RCT · Piotr Fudalej
Who these studies take
Of the 5 Open Bite studies recruiting now, 2 (40%) set no upper age limit and 3 (60%) stop at 75 or younger. 3 (60%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (60%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (60%) | 3 (60%) |
| 18 | 4 (80%) | 4 (80%) |
| 30 | 4 (80%) | 4 (80%) |
| 40 | 3 (60%) | 3 (60%) |
| 50 | 3 (60%) | 3 (60%) |
| 65 | 2 (40%) | 2 (40%) |
| 75 | 2 (40%) | 2 (40%) |
| 85 | 2 (40%) | 2 (40%) |
Across all 34 studies, recruiting or not: 79% stop at 75 or younger and 79% at 65; 74% take children; 3% are for women only and 0% for men only; 29% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Open Bite studies take
Of 24 interventional studies with no phase under Open Bite, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 17 mo10–36 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
- Ozonated Olive Oil for Mini-Screw Complications in Molar IntrusionOct 28, 2026NCT07900022
Studies
Recruiting first, then most recently updated. Showing 34 of 34. search them.
- Clinical Comparison of Clear Aligners and Fixed Appliances in Dental Anterior Open BiteNot yet recruitingNCT07778108Not applicable
- IOA Preventing Occlusal Changes With MAD UseRecruitingNCT07103941Not applicable1 country
- Investigate the Effectiveness of 3D-printed Shape Memory Aligners in the Treatment of Anterior Open BiteRecruitingNCT07420777Not applicable1 country
- Stability of Orthodontic Treatment of Anterior Open-biteRecruitingNCT075671051 country
- Treatment Effects of Vertical Holding Appliance in Comparison to Zachrisson Transpalatal Arch on Anterior Open Bite CorrectionRecruitingNCT07379632Not applicable1 country
- Myofunctional Therapy in Open Bite - RCTNot yet recruitingNCT06574490Not applicable
- Evaluation Treatment Outcomes of Anterior Open Bite Treated by Temporary Anchorage DevicesEnrolling by invitationNCT06147739Not applicable1 country
- Evaluation of Artificial Intelligence Models for Diagnosis of Anterior Open Bite MalocclusionRecruitingNCT061408491 country
- Ozonated Olive Oil for Mini-Screw Complications in Molar IntrusionCompletedNCT07900022Not applicable1 country
- Oral Myofunctional Pattern in Children With Anterior Open BiteCompletedNCT07045779Not applicable1 country
- Conventional Palatal Crib Versus Bonded Spurs for Anterior Open Bite TreatmentCompletedNCT07509567Not applicable1 country
- Efficiency of Microosteoperforation for Accelerating Posterior Segment Intrusion in Skeletal Open Bite CasesCompletedNCT07761065Not applicable1 country
- Single Palatal Temporary Anchorage Device for Anterior Open BiteActive, not recruitingNCT04419805Not applicable1 country
- Orthognathic Surgery in Anterior Open Bite: a Retrospective Study of 50 Patients With Initial Tongue MalpositionCompletedNCT075206821 country
- Anterior Open Bite Closure by Clear Aligners Versus Fixed Appliances in Adult Patients With Skeletal Open Bite: A Randomized Clinical Trial.Active, not recruitingNCT07117006Not applicable1 country
- Reliability of Artificial Intelligence for Treatment Decision for Adult Skeletal Open Bite PatientsCompletedNCT069929081 country
- Effects of Open Bite Activator and Skeletal Anchorage-Supported Vertical Elastics on the Masseter MuscleCompletedNCT06949527Not applicable1 country
- Treatment of Skeletal Open Bite With Open Bite Activator and Skeletal Anchorage-Supported Vertical ElasticsCompletedNCT06936371Not applicable1 country
- A Comparison of Two Protocol for Maxillary Molar Intrusion Buccal Miniscrew and TPA Versus Vertical Holding ApplianceStatus unknownNCT05433051Not applicable1 country
- Maxillary Versus Bi-Maxillary Posterior Segments Intrusion Adult Subjects With Skeletal Open BiteCompletedNCT04713280Not applicable1 country
- Effect of Customized Lateral Nasal Wall Osteotomy on the Pterygomaxillary Separation During le Fort I Down-fractureCompletedNCT06233188Not applicable1 country
- Effects of Tongue Tamers as an Early Treatment of Anterior Open BiteCompletedNCT05792553Not applicable1 country
- Correction of Anterior Open Bite With Skeletally Anchored Extrusion ArchCompletedNCT05492864Not applicable1 country
- Early Treatment of Anterior Open Bite Using the Rapid Molar IntruderCompletedNCT05657522Not applicable1 country
- Stability of Anterior Open Bite Treatment Using Extrusion ArchesCompletedNCT05599074Not applicable1 country
- The Use of Statically Determinate Force System in Closure of Anterior Open Bite in Adults.CompletedNCT04901221Not applicable1 country
- Palatal Crib Versus Bonded Spurs in Early Treatment of Anterior Open Bite Caused by Non-nutritive Sucking Habits: RCTStatus unknownNCT05313399Phase 3
- Anterior Open Bite Treatment With Bonded Spurs Associated With Build-ups Versus Conventional Bonded SpursCompletedNCT03702881Not applicable1 country
- Early Treatment of Skeletal Anterior Open Bite by Two AppliancesCompletedNCT04338217Not applicable1 country
- Prevalence of Anterior Open Bite in a Group of Egyptian Children Aged Eight Years and AboveStatus unknownNCT034944391 country
- Accuracy of Computer Guided Surgery (vs) Conventional Model Surgery in Treatment of Skeletal Open BiteStatus unknownNCT03277443Not applicable
- Molar Intrusion in Open Bite TreatmentCompletedNCT02865213Not applicable1 country
- Molar Intrusion Using High Pull HeadgearCompletedNCT02951286Not applicable1 country
- Implications of Pacifier Use in Israeli ChildrenStatus unknownNCT012498851 country