An interventional study of Experimental: Corticotomy¬-Assisted Canine Retraction and Active Comparator / Control: Conventional Canine Retraction in Malocclusion, Corticotomy and Canine Retraction, sponsored by Tanzila Rafique. Enrolling by invitation at 1 site in Bangladesh. Open to participants aged 16 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by Tanzila Rafique · Not applicable, Interventional, and Treatment
The goal of this split-mouth randomized clinical trial is to evaluate the effectiveness of corticotomy on maxillary canine retraction rate compared to conventional orthodontic techniques. Each participant acts as their own control. After bilateral maxillary first premolar extractions, one quadrant is randomly assigned to receive corticotomy before retraction, while the contralateral quadrant undergoes standard orthodontic retraction without corticotomy.
The goal of this split-mouth randomized clinical trial is to evaluate the effectiveness of corticotomy on maxillary canine retraction rate compared to conventional orthodontic techniques. The main question it aims to answer is Does corticotomy-assisted canine retraction accelerate the rate of tooth movement compared to conventional canine retraction methods? Researchers will evaluate the rate of canine retraction, root resorption, bone density, and pocket depth after corticotomy during the canine retraction phase.
Participants will:
469 studies on the registry are indexed under Malocclusion; 91 are open to participants now.
This study's planned enrollment of 24 is below the median of 36 across 383 interventional studies indexed under Malocclusion.
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Exclusion Criteria:
Corticotomy will be performed on one maxillary quadrant before initiating standardized canine distalization.
Procedure: Experimental: Corticotomy¬-Assisted Canine Retraction · Procedure: Active Comparator / Control: Conventional Canine Retraction
Conventional canine retraction will be performed on the contralateral quadrant without corticotomy under identical orthodontic mechanics.
Procedure: Experimental: Corticotomy¬-Assisted Canine Retraction · Procedure: Active Comparator / Control: Conventional Canine Retraction
Corticotomy will be performed on one maxillary quadrant before initiating standardized canine distalization.
Conventional canine retraction will be performed on the contralateral quadrant without corticotomy under identical orthodontic mechanics.
Rate of maxillary canine retraction
Linear distal movement of the maxillary canine measured on CBCT scans relative to a fixed anatomical landmark (e.g., the cusp tip, the center of the tooth (midpoint of the line joining the cusp tip and root apex), and the root apex) to compare the corticotomy-assisted side with the conventional side.
Time frame: 6 months
Overall rate of maxillary canine retraction
* A frontal reference plane (FP) was constructed to the mid-sagittal and horizontal planes, passing through the incisive foramen and the long axis of the canine. * Three landmarks identified on each CBCT volume: the cusp tip, the center of the tooth, and the root apex. * The perpendicular distance from each of these three landmarks to the FP measured at both experimental and control sides. * The amount of retraction at the cusp tip, center, and root apex calculated as the difference in distdistance-to-FP between successive time point and across the full retraction period.
Time frame: Baseline to Post-retraction (6months)
Comparison of amount of canine root resorption between the corticotomy- assisted side and the conventional side.
-Root resorption was calculated (in mm) as the difference in canine length, from cusp tip to root apex, between the pre- and post-retraction CBCTs.
Time frame: Baseline to Post-retraction (6months)
The rate of retraction at each landmark
The rate of retraction at each landmark was calculated by dividing the amount of movement by the time elapsed (mm per month).
Time frame: Baseline to Post-retraction (6months)
Measurement of bone density between the corticotomy-assisted side and the conventional side.
Bone density was measured between the corticotomy-assisted side and the conventional side over six months by sequential CBCT scans(with the same field of view and the same voxel resolution) taken at T0 (baseline), T1 (3 months), and T2 (6 months).
Time frame: Baseline to Post-retraction (6months)
Measurement and comparison of the pocket depth of the canine(in mm) between the corticotomy-assisted and the conventional side.
Pocket depth of the canine was measured between the corticotomy-assisted side and the conventional side by periodontal probing at T0 (baseline), T1 (3 months), and T2 (6 months).
Time frame: Baseline to Post-retraction (6months)
Plan to share: No
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Tanzila Rafique