An interventional study of Clear aligners with FM (Fluid Move) design in Malocclusion, sponsored by Shanghai Jiao Tong University School of Medicine. Recruiting at 1 site in China. Open to participants aged 12 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-10-27.
Sponsored by Shanghai Jiao Tong University School of Medicine · Not applicable, Interventional, and Treatment
This trial tests whether a new method (FM) for moving back teeth can shorten clear-aligner treatment. All participants use FM, which moves the canine and first molar back together instead of one tooth at a time like the standard method. There is no comparison group; results will be compared with published studies and past records to plan a larger direct comparison. Participants wear FM aligners, have check-ups, scans, and photos at the start and at about 3 months, then check-ups every 1-3 months, for about 6 months total. People aged 12-45 with misaligned teeth needing back teeth moved back, healthy gums, and no need for tooth removal or jaw surgery can join.
The goal of this clinical trial is to learn if a new way to move the back teeth can shorten treatment time for people straightening their teeth with clear aligners. Clear aligners are clear, removable plastic trays that slowly move the teeth into a straighter position.
The main questions it aims to answer are:
This study has one group. Everyone who joins will use the new method, called FM (Fluid Move). The FM method moves the canine and the first molar back at the same time, while the other teeth follow along. This is different from the standard method, called V-pattern, which moves the teeth back one at a time from the back of the mouth forward.
There is no comparison group in this study. Researchers will compare the results with results from published studies and with records from people treated in the past with the standard method. The results will help researchers plan a larger study that compares the two methods directly.
Participants will:
People ages 12 to 45 can take part if they have crooked or misaligned teeth and need their back teeth moved back to make room for the front teeth. They must have healthy gums and must not need tooth removal or jaw surgery.
323 studies on the registry are indexed under Malocclusion; 85 are open to participants now.
This study's planned enrollment of 10 is below the median of 37 across 242 interventional studies indexed under Malocclusion.
Browse Malocclusion studies →Shanghai Jiao Tong University School of Medicine is the lead sponsor of 374 studies on the registry; 110 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
After providing informed consent, all enrolled participants will receive Angelalign clear aligners using FM shell structure technology, with the treatment plan designed to move teeth using the FM technique. All other aspects of the aligner material, aligner design, and wear requirements are the same as with conventional clear aligner treatment.
Device: Clear aligners with FM (Fluid Move) design
Clear aligners with FM (Fluid Move) design
Time to Canine Distalization Completion (Months From Treatment Start to Canine Reaching Planned Position)
From treatment start (T0) to canine distalization completion (T1), assessed up to 6 months
Time frame: From treatment start (T0) to canine distalization completion (T1), assessed up to 6 months
Molar Distalization Achievement Rate (Percent)
Achievement rate (%) = (a ÷ b) × 100, where: a = achieved tooth movement, calculated as the difference in displacement coordinates between the actual and planned tooth positions after digital model superimposition, using digital models obtained by intraoral optical scanning; and b = planned tooth movement, obtained from the treatment plan designed in the aligner design software.
Time frame: Time Frame: At T1 (about 3 months after treatment start)
Plan to share: Yes — De-identified individual participant data underlying the results reported in publications will be available, including demographic and baseline characteristics, digital model measurements, time to canine distalization completion, and molar distalization achievement rate. Data will be available beginning 6 months after publication of the primary results and ending 5 years after publication. Data will be shared with qualified researchers who provide a methodologically sound proposal, following approval by the Ethics Committee of Shanghai Ninth People's Hospital and execution of a data use agreement. Requests should be directed to the corresponding author. Because this study enrolls only 10 participants at a single center, individual-level data may be limited or released in summary form where necessary to protect participant privacy.
No publications or documents are linked to this record.
Started Sep 2026 (actual). Primary completion is estimated for Apr 2027, 7 months after the start.
Of 153 non-industry interventional studies with no phase under Malocclusion, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 30. This study's planned 7 months is below that.
Counting every sponsor, half of 163 studies reached it within 19 months; a quarter within 10 and three quarters within 32.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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