Malocclusion, Angle Class II clinical trials
The registry lists 124 studies for Malocclusion, Angle Class II across more than 10 countries. 19 are recruiting or about to start. 113 of them are mainly about Malocclusion, Angle Class II (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
Get an email when these change. Save the Malocclusion, Angle Class II studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Status
Who runs them
Damascus University (30) · Postgraduate Institute of Dental Sciences Rohtak (11) · Al-Azhar University (9) · Cairo University (5) · Ain Shams University (3) · Wroclaw Medical University (3) · Bezmialem Vakif University (3) · University of Rome Tor Vergata (2)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Nov 2026Discision as Acceleration Method in Canine Retraction in Orthodontics With Aligner and Fixed Appliances in Young Adults a Split Mouth Study · Al-Azhar University
- Dec 2026Comparing 3D-Printed and Milled Titanium Plates in Jaw Surgery (Le Fort I): Accuracy and Operative Time · Future University in Egypt
- Dec 2026EVALUATION OF TREATMENT CHANGES IN CLASS II DIVISION 1 MALOCCLUSION DURING EN MASSE RETRACTION OF UPPER ANTERIOR TEETH USING MINI IMPLANTS PLACED AT INFRAZYGOMATIC CREST AND INTERRADICULAR SITES A RANDOMIZED CLINICAL TRIAL. · Postgraduate Institute of Dental Sciences Rohtak
- Jan 2027Dento-skeletal Effects of Clear Twin Block Treatment at Specific Period in Growing Patients · University of Baghdad
- Feb 2027LLLLT vs Piezocision in Accelerating Orthodontic Canine Retraction · Hesham Nabil Ali Al-Qamhawy
- Jun 2027Twin-Block and LIPUS for TMJ Outcomes in Skeletal Class II Patients · Al-Azhar University
- Jul 2027Treatment of Skeletal Class II Malocclusion With Modified Twin-Block Appliance With Clear Plates · Hama University
- Aug 2027Maxillary Patient Specific Implants in Bimaxillary Orthognathic Surgery · Esbjerg Hospital - University Hospital of Southern Denmark
- Sep 2027The Effectiveness of the Twin Block and Carriere Motion Appliances in Post-pubertal Patients and an Evaluation of the Impact of Class II Malocclusion and Its Correction on Oral Health-related Quality of Life · Aslam Alkadhimi
Who these studies take
Of the 10 Malocclusion, Angle Class II studies recruiting now, 1 (10%) set no upper age limit and 9 (90%) stop at 75 or younger. 7 (70%) take children under 18. 1 (10%) are for women only and 0 (0%) for men only; 2 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (40%) | 3 (30%) |
| 18 | 4 (40%) | 4 (40%) |
| 30 | 2 (20%) | 2 (20%) |
| 40 | 1 (10%) | 1 (10%) |
| 50 | 1 (10%) | 1 (10%) |
| 65 | 1 (10%) | 1 (10%) |
| 75 | 1 (10%) | 1 (10%) |
| 85 | 1 (10%) | 1 (10%) |
Across all 124 studies, recruiting or not: 86% stop at 75 or younger and 85% at 65; 80% take children; 10% are for women only and 2% for men only; 40% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Malocclusion, Angle Class II studies take
Of 86 interventional studies with no phase under Malocclusion, Angle Class II, half reached primary completion within 15 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 15 mo11–22 · 86 studies | — | 15 mo11–22 · 86 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered3
- Dento-skeletal Effects of Clear Twin Block Treatment at Specific Period in Growing PatientsNov 9, 2026NCT07924982
- Discision as Acceleration Method in Canine Retraction in Orthodontics With Aligner and Fixed Appliances in Young Adults a Split Mouth StudyNov 5, 2026NCT07920276
- Root Shortening With Three Different Methods of Upper Anterior Teeth RetractionOct 30, 2026NCT07906951
Studies
Recruiting first, then most recently updated. Showing 50 of 124. Browse all 124 → or search them.
- Dento-skeletal Effects of Clear Twin Block Treatment at Specific Period in Growing PatientsRecruitingNCT07924982Not applicable1 country
- Discision as Acceleration Method in Canine Retraction in Orthodontics With Aligner and Fixed Appliances in Young Adults a Split Mouth StudyEnrolling by invitationNCT07920276Not applicable1 country
- Comparing 3D-Printed and Milled Titanium Plates in Jaw Surgery (Le Fort I): Accuracy and Operative TimeRecruitingNCT07841067Not applicable1 country
- Treatment of Skeletal Class II Malocclusion With Modified Twin-Block Appliance With Clear PlatesRecruitingNCT05950581Not applicable1 country
- 3D Printed Occlusal Splints for Intraoperative UseNot yet recruitingNCT07079111Not applicable
- Long-term Stability of Treatment With the Twin Block ApplianceEnrolling by invitationNCT077524981 country
- Twin-Block and LIPUS for TMJ Outcomes in Skeletal Class II PatientsRecruitingNCT07676695Not applicable1 country
- LLLLT vs Piezocision in Accelerating Orthodontic Canine RetractionRecruitingNCT07466641Not applicable1 country
- EVALUATION OF TREATMENT CHANGES IN CLASS II DIVISION 1 MALOCCLUSION DURING EN MASSE RETRACTION OF UPPER ANTERIOR TEETH USING MINI IMPLANTS PLACED AT INFRAZYGOMATIC CREST AND INTERRADICULAR SITES A RANDOMIZED CLINICAL TRIAL.RecruitingNCT07405905Not applicable1 country
- Comparison of Early Interceptive Orthodontic Appliances (Traditional and Novel) and Later Fixed Appliance Treatment in Class II Malocclusion.Not yet recruitingNCT07404696Not applicable1 country
- The Effectiveness of the Twin Block and Carriere Motion Appliances in Post-pubertal Patients and an Evaluation of the Impact of Class II Malocclusion and Its Correction on Oral Health-related Quality of LifeNot yet recruitingNCT07292636Not applicable1 country
- Evaluation of a Novel Lip Bumper With Integrated Distal Shoe Appliance in Preventing Second Molar Impaction in Children With Anterior Deep BiteNot yet recruitingNCT07015385Not applicable
- Microbial Adherence, Surface Roughness, Effectiveness and Impact on Patients Between Conventional and 3D Printed Twin Block AppliancesRecruitingNCT06944860Not applicable1 country
- Facial Aesthetic Analysis Model Based on Clinical Cohort Phenotype to Explore 45° Facial Profile.Enrolling by invitationNCT06984666Not applicable1 country
- Three-Dimensional Evaluation of Pharyngeal Airway and Facial Dimension Changes in Skeletal Class II Patients Treated With Twin Block Versus Myobrace AppliancesEnrolling by invitationNCT06976749Not applicable1 country
- Mandibular Advancement Planning Based on Clinical OverjetNot yet recruitingNCT06653075Not applicable1 country
- Changes in the Sagittal Pharyngeal Airway Dimension Following Leveling and Alignement in Class II Division 2 PatientsRecruitingNCT06602518Not applicable1 country
- Maxillary Molar Distalization Supported by Mini-implants With the Advanced Molar Distalization Appliance (Amda®)RecruitingNCT06011382Not applicable1 country
- Effects of Modified Fixed Twin Block Versus Removable Twin Block on Skeletal Class 2 Growing Patients With Mandibular DeficiencyRecruitingNCT05993156Not applicable1 country
- Root Shortening With Three Different Methods of Upper Anterior Teeth RetractionCompletedNCT07906951Not applicable1 country
- Effects of Power Arm Application in Maxillary Canine DistalizationCompletedNCT07866976Not applicable1 country
- Palatal Guide Wire for Canine Control During Miniscrew-Supported DistalizationCompletedNCT07845227Not applicable1 country
- Pain and Comfort During Functional Orthodontic Treatment With Laser or Ultrasounic WavesCompletedNCT07852559Not applicable1 country
- Assesment of Ethnic Bias in an Artificial Intelligence Based Orthodontic Diagnosis SystemCompletedNCT071627531 country
- Root Shortening With Three Methods of Upper Front Teeth RetractionCompletedNCT07744685Not applicable1 country
- AI-Assisted Versus Conventional Orthodontic Diagnosis and Treatment PlanningCompletedNCT076907741 country
- A Novel Bi-dimensional Archwire for Miniscrew-supported En-masse RetractionCompletedNCT07664215Not applicable1 country
- Evaluating Laser and Piezocision vs. Piezocision Alone on Root Resorption and Gingival Health During Tooth RetractionCompletedNCT07442825Not applicable1 country
- Study of The Effects of Mandibular Advancement Aligners in Treating Children With Class II Division 1 MalocclusionCompletedNCT07420270Not applicable1 country
- Maxillary Patient Specific Implants in Bimaxillary Orthognathic SurgeryActive, not recruitingNCT06297109Not applicable1 country
- Dento-Alveolar Changes in Maxillary Incisors After En-Masse Retraction Using Two Power-Arm HeightsCompletedNCT07259720Not applicable1 country
- Evaluating the Efficacy of the Sliding Mechanisms on Round-section Arch WireCompletedNCT07243509Not applicable1 country
- Treatment of Class II Malocclusion With Excessive OverjetActive, not recruitingNCT04508322Not applicable1 country
- Patient-related Outcomes When Accelerating Upper Canine Retraction With Fixed Orthodontic AppliancesCompletedNCT06875037Not applicable1 country
- External Root Resorption and Periodontal Status During Retraction of the Upper Anterior TeethCompletedNCT06873490Not applicable1 country
- Distalization With Aligners: Anchorage OptionsCompletedNCT06631131Not applicable1 country
- Analysis of the Effect oh the Carriere Motion 3DCompletedNCT067858961 country
- Cephalometric Changes Following Retraction of the Upper Anterior Teeth Stimulated by Low-intensity Electrical CurrentCompletedNCT06639204Not applicable1 country
- Microanalysis of Changes in 3D Geometry of Orthodontic Mini-implantsActive, not recruitingNCT067433601 country
- Effects of the Herbst Appliance With Different Anchorages and Twin-Block Appliance in Class II MalocclusionActive, not recruitingNCT02411812Not applicable1 country
- Which is Better Piezosurgery or Piezosurgery With Laser in Accelerating Orthodontic Tooth MovementCompletedNCT05655169Not applicable1 country
- Crossbow Versus Forsus Springs in Mild to Moderate Class II Malocclusion CasesCompletedNCT01530516Not applicable1 country
- BRIUS Vs FFA EfficiencyCompletedNCT04347018Not applicable1 country
- Comparative Effect of Clear Aligner Mandibular Advancement and Twin Block Appliances in Class II MalocclusionCompletedNCT066097331 country
- Activator vs the EF Class II Standard in the Treatment of Severe Overjet in Angle Class II Division 1 MalocclusionCompletedNCT06566027Not applicable1 country
- Therapeutic Effects of Class II Elastics on Aligners in Different Vertical Skeletal PatternsStatus unknownNCT058532111 country
- Bone Anchored Carriere Motion ApplianceCompletedNCT05499221Not applicable1 country
- Mini-implant-supported Twin-Block in Treating Patients With Class II Division 1 MalocclusionCompletedNCT06403033Not applicable1 country
- "Three Dimensional Assessment of Maxillary Molars Following Distalization Using Two Different Approaches"CompletedNCT06240923Not applicable1 country
- Pharyngeal Airway Dimensions With Twinblock Versus Myobrace Appliances in Developing Skeletal Class II PatientsCompletedNCT05610150Not applicable1 country