Ileus clinical trials
The registry lists 167 studies for Ileus across more than 10 countries. 23 are recruiting or about to start. 136 of them are mainly about Ileus (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-28. Counting its narrower condition Intestinal Pseudo-Obstruction too: 193 studies, 29 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (6) · Cedars-Sinai Medical Center (4) · Bausch Health Americas, Inc. (4) · Tsumura USA (4) · University Hospital, Angers (4) · Chinese University of Hong Kong (4) · KU Leuven (3) · Erzincan Military Hospital (3)
What is being tested here
Drugs under test in Ileus studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ropivacaine | 1 | 0 | 1 |
| Alvimopan | 0 | 5 | 10 |
| Tranexamic Acid | 0 | 1 | 4 |
| Protease Inhibitor Formulation LB1148 | 0 | 1 | 3 |
| Methylnaltrexone | 0 | 1 | 3 |
| Neostigmine | 0 | 0 | 2 |
| Mosapride | 0 | 0 | 2 |
| Doripenem | 0 | 1 | 2 |
| Lidocaine | 0 | 0 | 2 |
| Glycopyrrolate | 0 | 0 | 1 |
Drug classes tested here Local anesthetics 1 open · Opioid antagonists 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8, phase 3 first
- Nov 2027Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery · Phase 3 · Xijing Hospital
- Dec 2026Low Pressure Pneumoperitoneum and Postoperative Ileus · Ohio State University
- Dec 2026Prevention of Postoperative Hernias in Emergency Surgery · Jan Kochanowski University
- Jan 2027Implementation of an Efferent Loop Stimulation Protocol Prior to Ileostomy Closure at La Paz University Hospital · Hospital Universitario La Paz
- Jun 2027Study of Treatment With Intensified Omeprazole Treatment to Prevent High Output Stoma 1 · Medical University of Gdansk
- Jun 2027Gastrointestinal Stimulation As a Treatment of Postoperative Ileus Following Extensive Surgery · University of Aarhus
- Jul 2027At-Home Bowel Stimulation · The Cleveland Clinic
- Aug 2027Rectus Sheath Catheters Following Midline Laparotomy · Asklepios Kliniken Hamburg GmbH
Who these studies take
Of the 19 Ileus studies recruiting now, 12 (63%) set no upper age limit and 4 (21%) stop at 75 or younger. 3 (16%) take children under 18. 2 (11%) are for women only and 0 (0%) for men only; 2 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (11%) | 2 (11%) |
| 18 | 18 (95%) | 16 (84%) |
| 30 | 17 (89%) | 15 (79%) |
| 40 | 17 (89%) | 15 (79%) |
| 50 | 16 (84%) | 15 (79%) |
| 65 | 16 (84%) | 15 (79%) |
| 75 | 16 (84%) | 15 (79%) |
| 85 | 14 (74%) | 14 (74%) |
Across all 167 studies, recruiting or not: 19% stop at 75 or younger and 11% at 65; 12% take children; 8% are for women only and 1% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Ileus studies take
Of 40 interventional studies with no phase under Ileus, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 19 mo7–53 · 40 studies | — | 19 mo7–53 · 40 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting2
- Rectus Sheath Catheters Following Midline LaparotomyOct 28, 2026NCT07099924
- The Food Network EffectOct 21, 2026NCT07618559
Studies
Recruiting first, then most recently updated. Showing 50 of 167. Browse all 167 → or search them.
- Rectus Sheath Catheters Following Midline LaparotomyRecruitingNCT07099924Not applicable1 country
- At-Home Bowel StimulationRecruitingNCT075744371 country
- The Food Network EffectRecruitingNCT07618559Not applicable1 country
- The Effect of Ostomy Care Education Applied With the Teach-Back Method to Ostomy-Opened Individuals on Self-Care Power, Ostomy Adjustment, and AnxietyRecruitingNCT077880791 country
- TU-100 for Accelerating GI Recovery After Major Abdominopelvic Surgery (RC & CAWR)Not yet recruitingNCT07765589Phase 2
- Oral Lactulose for Gastrointestinal Recovery After Complex AppendectomyRecruitingNCT07589465Not applicable1 country
- The Effect of Nasogastric Tube Placement on Complications in Patients With Small Bowel Obstruction - the SBO-TUBE TrialRecruitingNCT07574515Not applicable1 country
- Saudi Emergency Laparotomy AuditNot yet recruitingNCT074299291 country
- Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery PatientsRecruitingNCT07425249Not applicable1 country
- Use of Beetroot Juice to Protect Against Postoperative Ileus Following Colorectal Surgery: BEET IT StudyRecruitingNCT05133024Phase 21 country
- Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal SurgeryRecruitingNCT05334485Phase 2/31 country
- Study of Postoperative Ileus in Digestive SurgeryRecruitingNCT060189611 country
- Surgical Outcomes in Splenic Flexure Cancers: A Multicenter Comparison of Segmental vs. Extended Hemicolectomy (SPARROW Study)Enrolling by invitationNCT072895681 country
- Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal SurgeryNot yet recruitingNCT07271875Phase 3
- Low Pressure Pneumoperitoneum and Postoperative IleusRecruitingNCT05344417Not applicable1 country
- Study of Treatment With Intensified Omeprazole Treatment to Prevent High Output Stoma 1RecruitingNCT06917963Not applicable1 country
- Prevention of Postoperative Hernias in Emergency SurgeryRecruitingNCT068158221 country
- Implementation of an Efferent Loop Stimulation Protocol Prior to Ileostomy Closure at La Paz University HospitalRecruitingNCT069745001 country
- Gastrointestinal Stimulation As a Treatment of Postoperative Ileus Following Extensive SurgeryRecruitingNCT05752071Not applicable1 country
- Effect of Lollipop on Postoperative Gastrointestinal Recovery in ChildrenRecruitingNCT06108011Not applicable1 country
- Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean SectionRecruitingNCT05654649Phase 1/21 country
- Preventing Gastrointestinal Disturbance in Patients After Longitudinal Laparotomy.RecruitingNCT05923086Phase 21 country
- Chewing Gum on Postoperative Ileus in ChildrenRecruitingNCT03666377Not applicable1 country
- Association Between Preoperative Mediterranean Diet Adherence and Postoperative Bowel MotilityCompletedNCT078082811 country
- Study of the Efficience of Chewing-gum to Reduce the Duration of Postoperative IleusCompletedNCT05296967Not applicable1 country
- Coffee Consumption After Laparoscopic HysterectomyCompletedNCT07686510Not applicable1 country
- Abdominal Hot Water Bag Aplication Ileus CareCompletedNCT07248098Not applicable1 country
- Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory PathwayCompletedNCT02425774Phase 41 country
- The Effect of Chewing Gum on Nausea, Vomiting and Bowel Function After Colorectal SurgeryCompletedNCT06029790Not applicable1 country
- Pelvic Floor Peritoneal Closure to Prevent Postoperative Ileus in Mid-Low Rectal Cancer SurgeryActive, not recruitingNCT07432542Not applicable1 country
- Can Coffee/Caffeine Improve Post-Operative Gastrointestinal RecoveryCompletedNCT04547868Not applicable1 country
- Hand-made Extracorporeal Knotting Versus Clip for Stump Closure in Laparoscopic AppendectomyCompletedNCT07281612Early Phase 11 country
- The Impact of Sugammadex on Ileus After Abdominal Wall ReconstructionCompletedNCT05985343Phase 41 country
- Feasibility and Safety of an Ileus Management Protocol for Postoperative Ileus After Abdominal SurgeryCompletedNCT07194525Not applicable1 country
- Alvimopan as a Rescue Treatment of Postoperative IleusCompletedNCT04405037Phase 41 country
- Myoelectric Activity Following Colorectal Surgery and Return of Bowel FunctionCompletedNCT05298774Not applicable1 country
- Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory LaparotomyTerminatedNCT05017246Phase 21 country
- Intestinal Microbiota and Postoperative Ileus After Colorectal SurgeryCompletedNCT055127411 country
- The Impact of Manual Versus Mechanical Intestinal Suturing on the Incidence of Postoperative Complications Following Cystectomy With Ileal ConduitCompletedNCT06928220Not applicable1 country
- Optimizing the Previs Device for Prediction of Postoperative IleusCompletedNCT03505476Not applicable1 country
- Pedal Movement - Implementing Cycling as a Mobility OptionCompletedNCT06412991Not applicable1 country
- Preoperative Chewing Gum on Anxiety and Postoperative Nausea and Vomiting, Gastrointestinal FunctionActive, not recruitingNCT06603025Not applicable1 country
- Intravenous Nutrition in Hospitalized Patients: Comparison of Two OilsCompletedNCT01943409Phase 41 country
- Effect of Mosapride Citrate on Gastrointestinal Motility After Laparoscopic GastrectomyCompletedNCT04493125Not applicable1 country
- Study to Evaluate the Safety of Post-Operative TZP-101 (IV Ulimorelin) After Partial Bowel ResectionCompletedNCT01710982Phase 3
- The Use of Oral Naloxone to Prevent Post Spinal Fusion IleusTerminatedNCT03176316Phase 41 country
- A Study to Evaluate LB1148 for Return of Gastrointestinal Function and Adhesions in Subjects Undergoing Bowel ResectionCompletedNCT02836470Phase 21 country
- A Study to Evaluate LB1148 for Return of Bowel Function in Subjects Undergoing Bowel ResectionTerminatedNCT05470387Phase 31 country
- Effect of Chewing Gum and Drinking Fennel TeaCompletedNCT06403215Not applicable1 country
- Digital Manometry for Intra-Abdominal Pressure Measurement in IleusCompletedNCT06338813Not applicable1 country