An observational study in Post Abdominal Surgery, Gastrointestinal Motility Disorder and Postoperative Ileus, sponsored by Bahçeşehir University. Completed at 2 sites in Turkey (Türkiye). Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-09-08.
Sponsored by Bahçeşehir University · Observational
Postoperative bowel motility is an important indicator of recovery after abdominal surgery and may be influenced by preoperative nutritional status. Adherence to the Mediterranean diet has been associated with favorable gastrointestinal function because of its high content of dietary fiber, unsaturated fatty acids, polyphenols, and other bioactive compounds. This prospective observational cohort study aims to investigate the association between preoperative adherence to the Mediterranean diet and postoperative bowel motility in adults undergoing elective abdominal surgery. A total of 110 participants will be assessed for Mediterranean diet adherence using the Mediterranean Diet Adherence Screener (MEDAS). Nutritional status, dietary intake, and perioperative characteristics will be recorded. Postoperative bowel motility outcomes, including time to first bowel sound, first flatus, first defecation, oral intake, and hospital discharge, will be prospectively monitored. The findings are expected to improve understanding of the relationship between preoperative dietary patterns and postoperative gastrointestinal recovery.
Postoperative bowel motility is one of the most important indicators of recovery following abdominal surgery. Delayed gastrointestinal motility is associated with postoperative ileus, prolonged hospital stay, delayed oral feeding, and increased healthcare costs. Several factors, including surgical stress, anesthesia, inflammation, and preoperative nutritional status, may influence the recovery of bowel function after surgery.
The Mediterranean diet is characterized by a high intake of vegetables, fruits, legumes, whole grains, olive oil, nuts, and fish, and a low intake of red and processed meat. This dietary pattern provides dietary fiber, unsaturated fatty acids, polyphenols, antioxidants, and other bioactive compounds that may improve gut microbiota composition, reduce inflammation, and support normal gastrointestinal function. Previous studies have demonstrated beneficial effects of the Mediterranean diet on gastrointestinal health; however, evidence regarding its association with postoperative bowel motility remains limited.
This prospective observational cohort study aims to investigate the association between preoperative adherence to the Mediterranean diet and postoperative bowel motility in adults undergoing elective laparoscopic cholecystectomy. A total of 110 participants will be enrolled after ethics committee approval. Preoperative nutritional status, dietary intake, and adherence to the Mediterranean diet will be assessed using the Mediterranean Diet Adherence Screener (MEDAS), food frequency questionnaires, and three-day dietary records. Demographic, anthropometric, clinical, and perioperative data will also be collected.
Postoperative bowel function will be prospectively evaluated by recording the time to first bowel sound, first passage of flatus, first defecation, first oral intake, and hospital discharge. Dietary nutrient intake will be analyzed using a nutrition analysis software program. The association between Mediterranean diet adherence and postoperative bowel motility outcomes will be examined using appropriate statistical methods. The findings are expected to improve understanding of the role of preoperative dietary quality in postoperative gastrointestinal recovery and may contribute to optimizing perioperative nutritional management in patients undergoing abdominal surgery.
167 studies on the registry are indexed under Ileus; 23 are open to participants now.
This study's enrollment of 110 is below the median of 159 across 26 observational studies indexed under Ileus.
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The study population consisted of adults undergoing elective laparoscopic cholecystectomy at the General Surgery Clinic of İnönü University Faculty of Medicine Hospital. Participants were enrolled prospectively between February and April 2026. Preoperative nutritional status and adherence to the Mediterranean diet were assessed before surgery, and postoperative bowel motility outcomes were prospectively monitored during hospitalization.
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Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adults undergoing elective laparoscopic cholecystectomy who were enrolled in this prospective observational cohort study. Preoperative nutritional status and adherence to the Mediterranean diet were assessed before surgery. Participants were not assigned to exposure groups; subgroup analyses according to Mediterranean Diet Adherence Screener (MEDAS) scores were performed during statistical analysis. Postoperative bowel motility outcomes were prospectively recorded for all participants.
Time to first bowel sound
Time in hours from completion of surgery, defined as the record time of exit from the operating room, to the first documented bowel sound. Bowel sounds were assessed hourly by surgical residents and recorded on a standardised monitoring form.
Time frame: From completion of surgery until the first documented bowel sound, assessed during the postoperative hospital stay (up to 48 hours postoperatively).
Time to first flatus
Time in hours from completion of surgery, defined as the recorded time of exit from the operating room, to the first patient-reported passage of flatus.
Time frame: From completion of surgery until the first patient-reported passage of flatus, assessed during the postoperative hospital stay (up to 48 hours postoperatively).
Time to first defecation
Time in hours from completion of surgery, defined as the recorded time of exit from the operating room, to the first patient-reported postoperative defecation.
Time frame: From completion of surgery until the first patient-reported postoperative defecation, assessed during the postoperative hospital stay (up to 48 hours postoperatively).
Time to first oral fluid intake
Time in hours from completion of surgery, defined as the recorded time of exit from the operating room, to the first documented postoperative oral fluid intake. The time of oral fluid intake was obtained from hospital records.
Time frame: From completion of surgery until the first documented oral fluid intake, assessed during the postoperative hospital stay (up to 48 hours postoperatively).
Postoperative Length of Hospital Stay
Time in hours from completion of surgery, defined as the recorded time of exit from the operating room, until hospital discharge. The time of discharge was obtained from hospital records.
Time frame: From completion of surgery until hospital discharge, assessed up to 60 days postoperatively.
Plan to share: No
Ran from Jan 2026 to primary completion in Apr 2026, 3 months.
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