An observational study in Postoperative Ileus and Surgery-Complications, sponsored by University Hospital, Angers. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-15.
Sponsored by University Hospital, Angers · Observational
Postoperative ileus (POI) after colorectal surgery is frequent and is a burden for national health authority because it increases the morbidity and the length of hospital stay.
Some of the stage of the mechanism of POI are known and are now targeted to reduce its occurence but despite these measures, POI still happens in 10-30% of surgeries.
The role of the intestinal microbiota in POI is unknown while it could be a new target to reduce its duration or its occurence.
167 studies on the registry are indexed under Ileus; 23 are open to participants now.
This study's enrollment of 64 is below the median of 159 across 26 observational studies indexed under Ileus.
Browse Ileus studies →University Hospital, Angers is the lead sponsor of 478 studies on the registry; 120 are open to participants now.
Counted across the registry records on this site, refreshed daily.
10 patients with POI and 10 patients without POI selected in the consecutive patients undergoing colorectal surgery during the period of inclusion.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients that experience POI after colorectal surgery. POI is defined by the presence of 2 of the 5 criteria of Vather from the first postoperative day. The first 10 consecutive patients experiencing POI will be included in the study.
Other: Feces collection
Patients that do not experience POI. The 10 patients having the fastest recovery of gastro-intestinal functions after surgery during the period of inclusion will be included in the study
Other: Feces collection
Feces will be collected, at home, by the patient., by using a collection kit. The stools are collected in the 2 last days before surgery. After surgery, the first stool is collected, during the hospitalization, by using the same kit. Stools are conserved in the same condition, before being frozen in our local biologic ressources center.
Composition of the feces microbiota before surgery
The composition of the microbiota will be assessed by the analysis of the region V3 V4 of the 16S rRNA, amplificateur by high flow sequencing
Time frame: within the 2 last days before surgery
Composition of the feces microbiota after surgery
The composition of the microbiota will be assessed by the analysis of the region
Time frame: up to the first postoperative stools, an average of 3 postoperative days
This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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