Hyperparathyroidism, Primary clinical trials
The registry lists 104 studies for Hyperparathyroidism, Primary across more than 10 countries. 23 are recruiting or about to start. 82 of them are mainly about Hyperparathyroidism, Primary (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.
Get an email when these change. Save the Hyperparathyroidism, Primary studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Amgen (7) · Columbia University (6) · Nantes University Hospital (4) · M.D. Anderson Cancer Center (4) · The Cleveland Clinic (3) · University of Aarhus (3) · University of Pennsylvania (3) · Post Graduate Institute of Medical Education and Research, Chandigarh (2)
What is being tested here
Drugs under test in Hyperparathyroidism, Primary studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Dec 2026Patient Navigation to Improve Surgical Access in Primary Hyperparathyroidism · University of Pennsylvania
- Dec 202618F-choline Positron-emission-tomography - Computed-tomography Compared to Conventional Imaging for Localizing Diseased Parathyroid Glands in Primary Hyperparathyroidism · Region Skane
- Sep 2027Parathyroid Adenoma Detection With Rubidium-82 Imaging · Matthieu Pelletier-Galarneau, MD MSc
- Nov 2027Treating PHPT With the nPulse™ Vybrance™ PE System · Pulse Biosciences, Inc.
Who these studies take
Of the 15 Hyperparathyroidism, Primary studies recruiting now, 10 (67%) set no upper age limit and 0 (0%) stop at 75 or younger. 2 (13%) take children under 18. 1 (7%) are for women only and 0 (0%) for men only; 3 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (13%) | 2 (13%) |
| 18 | 14 (93%) | 13 (87%) |
| 30 | 14 (93%) | 13 (87%) |
| 40 | 15 (100%) | 14 (93%) |
| 50 | 15 (100%) | 14 (93%) |
| 65 | 15 (100%) | 14 (93%) |
| 75 | 15 (100%) | 14 (93%) |
| 85 | 14 (93%) | 14 (93%) |
Across all 104 studies, recruiting or not: 8% stop at 75 or younger and 4% at 65; 18% take children; 8% are for women only and 0% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hyperparathyroidism, Primary studies take
Of 20 interventional studies with no phase under Hyperparathyroidism, Primary, half reached primary completion within 35 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 35 mo26–84 · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
- Treating PHPT With the nPulse™ Vybrance™ PE SystemNov 3, 2026NCT07912892
Studies
Recruiting first, then most recently updated. Showing 50 of 104. Browse all 104 → or search them.
- Natural History Study of Parathyroid DisordersRecruitingNCT049699261 country
- Treating PHPT With the nPulse™ Vybrance™ PE SystemNot yet recruitingNCT07912892Not applicable1 country
- Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid TumorsRecruitingNCT07444723Phase 2/31 country
- Parathyroid Adenoma Detection With Rubidium-82 ImagingEnrolling by invitationNCT070994041 country
- Bisphosphonate Prior to Parathyroidectomy in Primary HyperparathyroidismRecruitingNCT06859580Phase 41 country
- Evaluation of the Role of Luteinizing Hormone (LH) and Human Chorionic Gonadotropin (hCG) in Adult Patients Undergoing Assessment for Endocrine DisordersRecruitingNCT078241021 country
- NIRAF-camera Versus Conventional Surgery in Preoperative Imaging Negative Primary HyperparathyroidismRecruitingNCT07812649Not applicable1 country
- Amino Acid Transporter System PET/CT Imaging in AATS-Related DiseasesRecruitingNCT073794631 country
- Patient Navigation to Improve Surgical Access in Primary HyperparathyroidismRecruitingNCT06562881Not applicable1 country
- Shortwave Infrared Surgical Imaging Device StudyEnrolling by invitationNCT077444251 country
- Molecular and Immunohistochemical Profiling of Tumors in Patients With Parathyroid TumorsRecruitingNCT030394391 country
- Parathyroid Tumor Clonal StatusRecruitingNCT059978101 country
- Parathyroid Assessment of Symptoms French VersionRecruitingNCT064504311 country
- Aldosterone Variations in Patients With Primary Hyperparathyroidism After SurgeryNot yet recruitingNCT073889141 country
- Cohort Primary HyperparathyroidismRecruitingNCT054690871 country
- 18F-choline Positron-emission-tomography - Computed-tomography Compared to Conventional Imaging for Localizing Diseased Parathyroid Glands in Primary HyperparathyroidismRecruitingNCT07138820Not applicable1 country
- WHITE CAP: Intra-operative Parathyroid Tissue Sensor (PTS)-Guided Assessment of Parathyroid Viability and Surgical Decision-MakingNot yet recruitingNCT07043010Not applicable1 country
- Is Intraoperative PTH Monitoring Obsolete in Times of Choline PET/CT? a Prospective Multicenter Cohort Study to Determine Whether the Regular Preoperative Use of Choline-PET/CT Scan Obviate the Need for Intraoperative PTH-measurement in Patients with Primary HyperparathyreoidismNot yet recruitingNCT068046811 country
- Autofluorescence in Surgery for Primary HyperparathyroidismRecruitingNCT06230380Not applicable1 country
- Diagnostic Performance of [11C]Choline PET/CT In the Preoperative Assessment of Primary HyperparathyroidismNot yet recruitingNCT066479661 country
- Calcitonin Pre-treatment to Improve SPECT-CT SensitivityRecruitingNCT03935984Phase 41 country
- Genetic Bases of Neuroendocrine Neoplasms in Mexican PatientsRecruitingNCT065235821 country
- The Bone-parathyroid Crosstalk in Primary HyperparathyroidismNot yet recruitingNCT055564991 country
- Evaluation of the Role of Intraoperative Neuromonitoring(IONM) in Patients Undergoing Parathyroid Surgery for Solitary Parathyroid AdenomaCompletedNCT07836335Not applicable1 country
- Evaluation of the Interest of the Medical Device Called "Fluobeam" in the Localization, Visualization of the Parathyroid Glands for Patients With Mild Primary HyperparathyroidismCompletedNCT03643081Not applicable1 country
- Glycemic Control, Type II Diabetes, ParathyroidectomyActive, not recruitingNCT057617431 country
- 18F-Fluorocholine Positron Emission Tomography (PET) for the Detection of Parathyroid AdenomasCompletedNCT04895631Phase 31 country
- Evaluation of a Cincalcet Suppression TestCompletedNCT01103206Phase 41 country
- Primary Hyperparathyroidism and Gut MicrobiotaTerminatedNCT049486711 country
- Surgery for Primary Hyperparathyroidism (pHPT) in Patients Older Than 65 Years Compared With Follow-upCompletedNCT01087619Not applicable1 country
- Upfront Ultrasound for Preoperative Localization in Primary HyperparathyroidismCompletedNCT070688671 country
- Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During ParathyroidectomyCompletedNCT05152927Not applicable1 country
- Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During ParathyroidectomyCompletedNCT05022641Not applicable1 country
- Near Infrared Autofluorescence Imaging in Minimally-Invasive Video-Assisted Parathyroidectomy (NIRAF MIVAP Study)CompletedNCT067797601 country
- The Midwest Head and Neck Cancer Consortium Multi-Institutional Parathyroid RegistryCompletedNCT014097981 country
- Preliminary Study Concerning the Validity of Parathyroid Exploration on a CZT CameraCompletedNCT02854345Not applicable1 country
- Object Assessment of Improvement in Non-Specific Symptoms After Parathyroidectomy for Primary HyperparathyroidismCompletedNCT063378251 country
- Primary Hyperparathyroidism: Short-term Calcimimetics Treatment - Relevance for Parathyroid Surgery Decisions?CompletedNCT02227264Not applicable1 country
- Circulating miRNA in Primary HyperparathyroidismCompletedNCT039311091 country
- Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During ParathyroidectomyCompletedNCT04299425Not applicable1 country
- A Retrospective Analysis of the Diagnostic Performance of 11C-choline PET/CT in Primary HyperparathyroidismCompletedNCT04608253
- Bone Microarchitectural Database Constitution From HR-pQCT Device in Clinical Situation Potentially Associated With Bone LossTerminatedNCT02532439Not applicable1 country
- Cohort Trial on Perioperative Localization Techniques of Parathyroid AdenomasTerminatedNCT04013100
- FCH PET/MRI Parathyroid LocalizationCompletedNCT03324893Not applicable1 country
- Gait and Balance Parameters Before and After Parathyroidectomy in Patients With Primary HyperparathyroidismCompletedNCT03713671Not applicable1 country
- Evaluating Alternative Medical Therapies in Primary HyperparathyroidismCompletedNCT02525796Phase 2/31 country
- European Multicentric Study on Parathyroid CarcinomaStatus unknownNCT057896801 country
- The Crosstalk Between Calcium-sensing Receptor Signaling and Endocannabinoid System in Primary HyperparathyroidismCompletedNCT038316201 country
- Optimization and Individualization of Diagnostic Scintigraphy Protocol and Minimally Invasive Radio-guided Parathyroid SurgeryCompletedNCT04344886Not applicable1 country
- Impact of Parathyroidectomy on Renal FunctionStatus unknownNCT047980921 country