An observational study in Primary Hyperparathyroidism, sponsored by Central Hospital, Nancy, France. Status unknown at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-12-05.
Sponsored by Central Hospital, Nancy, France · Observational
Primary hyperparathyroidism (PHPT) is a disorder of one or more of the parathyroid glands. The parathyroid gland(s) becomes overactive and secretes excess amounts of parathyroid hormone (PTH). As a result, the blood calcium rises to a level that is higher than normal. PHPT is associated with several other metabolic complications as osteoporosis, kidney stones, hypertension, insulin resistance, cardiac calcifications, cardiac arrhythmias, and kidney failure. Renal function deterioration over time has also been reported. However, the role of parathyroidectomy on renal function remains controversial in patients with PHPT. In some studies, surgical cure of PHPT has been shown to halt renal function deterioration in patients with coexisting renal disease. On the other hand, other studies showed no significant impact of parathyroidectomy on renal function. Consequently, the goal of this study was to evaluate renal function before and after parathyroidectomy in a large cohort of patients with pHPT.
Primary hyperparathyroidism (PHPT) is a disorder of one or more of the parathyroid glands. The parathyroid gland(s) becomes overactive and secretes excess amounts of parathyroid hormone (PTH). As a result, the blood calcium rises to a level that is higher than normal. PHPT is associated with several other metabolic complications as osteoporosis, kidney stones, hypertension, insulin resistance, cardiac calcifications, cardiac arrhythmias, and kidney failure. Renal function deterioration over time has also been reported. However, the role of parathyroidectomy on renal function remains controversial in patients with PHPT. In some studies, surgical cure of PHPT has been shown to halt renal function deterioration in patients with coexisting renal disease. On the other hand, other studies showed no significant impact of parathyroidectomy on renal function. Consequently, the goal of this study was to evaluate renal function before and after parathyroidectomy in a large cohort of patients with pHPT.
Criteria are detailled in "Outcomes measures"
104 studies on the registry are indexed under Hyperparathyroidism, Primary; 23 are open to participants now.
This study's planned enrollment of 500 is above the median of 130 across 40 observational studies indexed under Hyperparathyroidism, Primary.
Browse Hyperparathyroidism, Primary studies →Central Hospital, Nancy, France is the lead sponsor of 798 studies on the registry; 186 are open to participants now.
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patients undergoing parathyroidectomy for primary hyperparathyroidism with surgical cure defined as postoperative normocalciemia
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
GFR and eGFR (kidney filtering)
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
surgical removal of parathyroid adenoma(s) with postoperative biological cure
Change in renal function
glomerular filtration rate (CKD in mL/min)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in calcium
Blood calcium level (in mg/L)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in parathormone
Blood parathormone level (in ng/dL)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in vitamin D
Blood vitamine D level (in ng/mL)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in urinary calcium
Urine calcium level (in mg/24h)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in insulin
Fasting blood insuline level (in mUI/L)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in glycemia
Fasting blood glucose level (in g/L)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in osteocalcin
Blood osteocalcin level (in ng/mL)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in bone alkaline phosphatases
Blood bone alkaline phosphatases level (in microgr/L)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in aldosterone
Blood aldosterone level (in pg/mL)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in renin
Blood active renin (in pg/mL)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in total cholesterol
Blood total cholesterol (in gr/L)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in HDL cholesterol
Blood HDL Cholesterol (in gr/L)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in LDL cholesterol
Blood LDL Cholesterol (in gr/L)
Time frame: preoperative, postoperative at 3, 6, and 12 months
Change in triglycerides
Blood triglycerides (in gr/L)
Time frame: preoperative, postoperative at 3, 6, and 12 months
CAC scoring on CT scan
CAC score (actual value)
Time frame: preoperative
Plan to share: Undecided
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This study is status unknown, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.
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Hyperparathyroidism, Primary →
Central Hospital, Nancy, France →