An interventional study of Sympathoexcitatory stressors and Sodium Nitroprusside in Hot Flashes, Menopause and Vasomotor System; Labile, sponsored by Mayo Clinic. Recruiting at 1 site in United States. Open to female participants aged 40 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-12.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Basic science
Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between hot flashes and neurovascular dysfunction and, by extension, cardiovascular disease in women.
339 studies on the registry are indexed under Hot Flashes; 56 are open to participants now.
This study's planned enrollment of 120 is above the median of 90 across 306 interventional studies indexed under Hot Flashes.
Browse Hot Flashes studies →Mayo Clinic is the lead sponsor of 3,269 studies on the registry; 672 are open to participants now.
Of its 452 completed or terminated interventional studies of FDA-regulated products, 321 (71%) have results posted.
Counted across the registry records on this site, refreshed daily.
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Exclusion Criteria:
- None.
Hot Flash frequency will be assessed in the study subjects during a screening period. Participants can then chose to participate 1 or 2 study visits- Protocol 1: Microvascular function and/or Protocol 2: Autonomic function
Other: Sympathoexcitatory stressors · Drug: Sodium Nitroprusside · Drug: Acetylcholine · Drug: Terbutaline · Drug: Norepinephrine
Muscle sympathetic nerve activity will be measured continuously at baseline and in response to sympathoexcitatory stressors, including a Valsalva maneuver, isometric handgrip exercise, a cold pressor test, and stepped hypercapnia.
Also known as: Valsalva maneuver, handgrip exercise, ice water, and hypercapnia
Sodium nitroprusside, used to test endothelium-independent vasodilation, will be infused through a brachial artery catheter at 0.25, 0.5, 1.0 and 2.0 ug/100ml tissue/min.
Also known as: Forearm vascular conductance response to sodium nitroprusside
Acetylcholine, used to test endothelium-dependent vasodilation, will be infused through a brachial artery catheter at 1.0, 2.0, 4.0, and 8.0 μg/100ml tissue/min
Also known as: Forearm vascular conductance response to acetylcholine
Terbutaline, a β2-Adrenergic selective agonist, will be infused through a brachial artery catheter at 0.1, 0.5, 1.0, and 2.0 μg/100ml tissue/min.
Also known as: Forearm vascular conductance response to terbutaline
Norepinephrine, an α-adrenergic vasoconstricting agent, will be infused through a brachial artery catheter at 1.0, 2.0, 4.0, and 8.0 ng/100ml tissue/min
Also known as: Forearm vascular conductance response to norepinephrine
Compare microvascular function in women with low and high frequency hot flashes
Change in forearm vascular conductance with intra-arterial drug infusions. Vascular conductance is an index of vascular tone and is assessed using a technique called venous occlusion plethysmography
Time frame: Continuous measurement of vascular conductance during infusion of each drug- 3min at baseline and at each drug dose (~60min total of continuous forearm vascular conductance measurements)
Compare sympathetic function in women with low and high frequency hot flashes
Muscle Sympathetic Nerve Activity will be directly using a technique called microneurography.
Time frame: Continuous measurement of muscle sympathetic nerve activity at rest and in response to stressors (~75min of continuous data collection once a sympathetic nerve signal is found)
Plan to share: No
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Studies of the drugs tested here: Nitroprusside · Acetylcholine · Terbutaline · Norepinephrine