An interventional study of Low Intensity Focused Ultrasound in Chronic Pain and Generalized Anxiety Disorder, sponsored by Virginia Polytechnic Institute and State University. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-09-11.
Sponsored by Virginia Polytechnic Institute and State University · Not applicable, Interventional, and Treatment
A proof of concept case study to investigate accelerated LIFU protocol in chronic pain and anxiety populations.
A single-arm, open label, 2 cohort (chronic pain/GAD) case study with extended (6 months) follow-up following accelerated low-intensity focused ultrasound for neuromodulation.
Exclusion Criteria:
Accelerated (repeat) LIFU application for neuromodulation
Device: Low Intensity Focused Ultrasound
Low-Intensity Focused Ultrasound applied multiple times in a single study visit.
Safety - monitoring of possible symptoms
Symptom monitoring before and after LIFU applications and throughout 6 months of follow-up. Each symptom is presented with a likert scale (absent, mild, moderate, severe) - along with a free response option for any symptoms not included in the list.
Time frame: Throughout study participation at multiple time points, approximately 6 months.
Changes in Chronic Pain - self report
Participants will complete the Brief Pain Inventory (BPI) at multiple time points throughout the 6 month period. This questionnaire asks participants to rate their pain on a 10 point scale (10 being the most pain).
Time frame: Multiple timepoints throughout the 6 month experimental timeframe.
Changes in Anxiety - self report
Participants will complete the Beck Anxiety Inventory (BAI) at multiple time points before and after LIFU application to track changes in anxiety throughout the 6 month timeframe. The BAI probes different symptoms of anxiety and participants rate it on a likert scale (not at all, mildly, moderately, or severely).
Time frame: Throughout the experimental timeframe, approximately 6 months.
Plan to share: No
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This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Virginia Polytechnic Institute and State University