A Phase 1 interventional study of Dietary Supplement: Acetate (Apple Cider Vinegar) in Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD) and Anxiety, sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's. Not yet recruiting. Open to participants aged 16 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-10-27.
Sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Phase 1, Interventional, and Treatment
The investigators aim to confirm pilot study findings (REB 119638) on the effects of delayed release apple cider vinegar (drACV). The investigators aimed to determine the feasibility that the acetate in ACV would counteract the problematic weight gain and metabolic side effects associated with the most common psychiatric medications. Our pilot study recruited 11 participants from the First Episode Mood and Anxiety Program (FEMAP) who had experienced (by self-report) weight gain concurrent with medication use. The investigators found that drACV was well tolerated with adherence above 90% and resulted in reduced LDL cholesterol, improved lipids in 7 participants, altered microbiota composition in the direction associated with improved metabolic and mental health outcomes, and the emergence of a potential "responder phenotype". The investigators did not, however, find significant effects on weight.
The investigators aim to expand that study by 1) including a larger sample; 2) Conducting a detailed analysis of the microbiome and identifying immune and genomic factors associated with response, thereby further defining responder and non-responder phenotypes that emerged in the initial analysis, 3) collecting additional biological, psychological, and social data to permit complex multivariate modelling on gene-environment interactions for mechanistic research.
The investigators will seek to recruit sixty-two participants from FEMAP, the General Adult Ambulatory Mental Health Services (GAAMHS) and Child and Adolescent Mental Health Services at LHSC. Participants need to have experienced weight gain by self-report and clinician estimation, be psychiatrically stable on steady doses of medication, and be between the ages of 16-45.
147 studies on the registry are indexed under Generalized Anxiety Disorder; 86 are open to participants now.
This study's planned enrollment of 62 is below the median of 100 across 120 interventional studies indexed under Generalized Anxiety Disorder.
Browse Generalized Anxiety Disorder studies →London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's is the lead sponsor of 329 studies on the registry; 134 are open to participants now.
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Exclusion Criteria:
16-45 year old patients on stable dose of psychiatric medication for treatment of mental health conditions.
Other: Dietary Supplement: Acetate (Apple Cider Vinegar)
Consumer-grade apple cider vinegar (ACV) capsules will have extra enteric coating applied for delivery further into the GI tract.
Cholesterol
Change in LDL cholesterol corresponding to 15% or greater reduction for responders, and less than 5% reduction for non-responders
Time frame: From enrollment to 12-week follow-up
No study locations are listed for this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Generalized Anxiety Disorder →
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's →