Fuchs' Endothelial Dystrophy clinical trials
The registry lists 92 studies for Fuchs' Endothelial Dystrophy across more than 10 countries. 27 are recruiting or about to start. 73 of them are mainly about Fuchs' Endothelial Dystrophy (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
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Who runs them
Centre Hospitalier Universitaire de Saint Etienne (5) · Massachusetts Eye and Ear Infirmary (4) · Cornea Research Foundation of America (4) · Centre Hospitalier Régional Metz-Thionville (3) · Kowa Research Institute, Inc. (3) · Maastricht University Medical Center (3) · Centre Hospitalier Universitaire de Besancon (2) · Oregon Health and Science University (2)
What is being tested here
Drugs under test in Fuchs' Endothelial Dystrophy studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| K-115 | 3 | 4 | 8 |
| EO2002 | 1 | 0 | 2 |
| Dexamethasone | 1 | 0 | 2 |
| Acetylcysteine | 1 | 0 | 1 |
| Fluorometholone | 1 | 0 | 1 |
| Netarsudil | 0 | 3 | 6 |
| TTHX1114 | 0 | 0 | 2 |
| Amphotericin B | 0 | 1 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9, phase 3 first
- Oct 2027Descemet Endothelial Thickness Comparison Trial II · Phase 3 · Stanford University
- Dec 2026The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal Dystrophy · University Hospital Dubrava
- Mar 2027PVEK Corneal Implant For Treatment of Corneal Edema · Precise Bio
- Mar 2027Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy · Centre Hospitalier Universitaire de Saint Etienne
- Apr 2027Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy · Massachusetts Eye and Ear Infirmary
- Jun 2027OCT in Fuchs' Dystrophy · Oregon Health and Science University
- Jul 2027Postoperative CCT in FECD vs. Non-FECD · Vienna Hospital Association
- Aug 2027Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction · Emmecell
- Oct 2027Plasma Rich in Growth Factors in Corneal Endothelial Transplantation · University of Miami
Who these studies take
Of the 22 Fuchs' Endothelial Dystrophy studies recruiting now, 16 (73%) set no upper age limit and 1 (5%) stop at 75 or younger. 2 (9%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (5%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (9%) | 2 (9%) |
| 18 | 12 (55%) | 12 (55%) |
| 30 | 19 (86%) | 19 (86%) |
| 40 | 21 (95%) | 21 (95%) |
| 50 | 22 (100%) | 22 (100%) |
| 65 | 22 (100%) | 22 (100%) |
| 75 | 22 (100%) | 22 (100%) |
| 85 | 19 (86%) | 19 (86%) |
Across all 92 studies, recruiting or not: 3% stop at 75 or younger and 0% at 65; 5% take children; 0% are for women only and 0% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 92. Browse all 92 → or search them.
- Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial DysfunctionRecruitingNCT07729137Phase 21 country
- A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal EctasiaRecruitingNCT021189221 country
- DT-168 in Keratoplasty Patients With Fuchs Endothelial Corneal DystrophyRecruitingNCT07024693Phase 21 country
- The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal DystrophyEnrolling by invitationNCT069695861 country
- Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal DystrophyRecruitingNCT04440280Phase 21 country
- Partial Range Of Field IOLs in DMEK-Enabled ProceduresNot yet recruitingNCT07441616Not applicable1 country
- Postoperative CCT in FECD vs. Non-FECDNot yet recruitingNCT07731945
- Prognosis of Posterior Lamellar KeratoplastyRecruitingNCT068594111 country
- Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal DystrophyRecruitingNCT07539012Not applicable1 country
- Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in FranceRecruitingNCT057423211 country
- Plasma Rich in Growth Factors in Corneal Endothelial TransplantationRecruitingNCT06261346Not applicable1 country
- Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 YearsEnrolling by invitationNCT07217249Not applicable1 country
- Influence of Supine Positioning on the Outcomes After Descemet Membrane Endothelial Keratoplasty (DMEK)RecruitingNCT07373821Not applicable1 country
- PVEK Corneal Implant For Treatment of Corneal EdemaRecruitingNCT07325097Phase 12 countries
- Study to Assess Safety and Tolerability of Multiple Doses of EO2002RecruitingNCT05636579Phase 11 country
- SUCCESS Score Validation in Fuchs DystrophyRecruitingNCT072653881 country
- The OPTIMISE StudyRecruitingNCT05716945Phase 41 country
- Safety and Efficacy of Tissue Engineered Endothelial KeratoplastyRecruitingNCT04319848Phase 11 country
- OCT in Fuchs' DystrophyRecruitingNCT042587871 country
- Comparison of Outcomes Between Femtosecond Laser-Assisted and Conventional Phacoemulsification in Fuchs Endothelial Corneal Dystrophy Patients With CataractsRecruitingNCT069661671 country
- Brillouin Microscopy Used to Evaluate Corneal Mechanical PropertiesNot yet recruitingNCT06914817Not applicable1 country
- FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United KingdomRecruitingNCT068817711 country
- Trial Comparing Cataract Surgery with Triple-DMEK in Patients with Cataract and Fuchs Endothelial Corneal DystrophyRecruitingNCT06425666Not applicable4 countries
- The Effects of Ripasudil in Patients with FED Undergoing Femtosecond Laser Assisted Cataract SurgeryRecruitingNCT06048380Phase 31 country
- Endothelial Side Up Inverted Femtosecond Laser Assisted DSAEKRecruitingNCT06652321Not applicable1 country
- Ripasudil for Enhanced Corneal Clearing Following Descemet Membrane Endothelial Keratoplasty in Fuchs' DystrophyRecruitingNCT03813056Phase 21 country
- Glanatec(R) for Descemet Stripping in Fuch's Endothelial DystrophyRecruitingNCT03249337Phase 41 country
- Descemet Endothelial Thickness Comparison Trial IIActive, not recruitingNCT05275972Phase 31 country
- The Belgian Endothelial Surgical Transplant of the CorneaActive, not recruitingNCT05436665Not applicable1 country
- A Multicenter Study Assessing the Efficacy and Safety of STN1010904 Ophthalmic Suspension 0.03% and 0.1% Compared With Vehicle in Subjects With Fuchs Endothelial Corneal Dystrophy (FECD)CompletedNCT05376176Phase 23 countries
- DISCOVER Study: Microscope-integrated Intraoperative OCT StudyCompletedNCT024232131 country
- A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)CompletedNCT05795699Phase 36 countries
- A Comparison of Visual Functions and Side-effects After DSAEK or DMEK for Fuchs' Endothelial DystrophyCompletedNCT04417959Not applicable1 country
- Impact of Donor Diabetes on DMEK Success and Endothelial Cell LossCompletedNCT05134480Not applicable1 country
- Assessment of Corneal Endothelial Function Following Hypoxic StressWithdrawnNCT04175938Phase 1/21 country
- A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)CompletedNCT05826353Phase 36 countries
- Prevalence of Fuchs Endothelial Corneal Dystrophy in a Population of Dermatology Patients.CompletedNCT071170711 country
- The Evaluation of Balanced Salt Solution During Cataract SurgeryCompletedNCT05853978Phase 41 country
- Study of Safety and Tolerability of EO2002 in the Treatment of Corneal EdemaCompletedNCT04894110Phase 11 country
- Study to Investigate the Safety and Efficacy of K-321 in Patients With Fuchs Endothelial Corneal Dystrophy (FECD) Following DescemetorhexisCompletedNCT04250207Phase 25 countries
- Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen ExposureCompletedNCT045643781 country
- PIONEER: Intraoperative and Perioperative OCT StudyCompletedNCT024231611 country
- Netarsudil Use After Descemtorhexis Without Endothelial KeratoplastyCompletedNCT04752020Early Phase 11 country
- TTHX1114(NM141) in Combination With DWEK/DSOCompletedNCT04676737Phase 21 country
- A Phase 1/ Phase 2 Study of TTHX1114(NM141)CompletedNCT04520321Phase 1/21 country
- Supine Positioning for Graft Attachment After Descemet Membrane Endothelial KeratoplastyCompletedNCT05399095Not applicable1 country
- Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in France.CompletedNCT039742301 country
- Trial of Netarsudil for Acceleration of Corneal Endothelial RestorationTerminatedNCT03971357Phase 2/31 country
- Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping OnlyTerminatedNCT045275231 country
- The ADVISE Study: Advanced Visualization In Corneal Surgery EvaluationCompletedNCT03763721Not applicable2 countries