A Phase 1 interventional study of EO2002 and Ripasudil in Corneal Edema, Corneal Endothelial Dystrophy and Endothelial Dysfunction, sponsored by Asociación para Evitar la Ceguera en México. Recruiting at 1 site in Mexico. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-08.
Sponsored by Asociación para Evitar la Ceguera en México · Phase 1, Interventional, and Treatment
The goal of this clinical study is to assess the safety of multiple intracameral injections of EO2002 with and without topical Ripasudil.
39 studies on the registry are indexed under Corneal Edema; 8 are open to participants now.
This study's planned enrollment of 12 is below the median of 52 across 31 interventional studies indexed under Corneal Edema.
Browse Corneal Edema studies →Asociación para Evitar la Ceguera en México is the lead sponsor of 60 studies on the registry; 6 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:
All ocular criteria apply to the study eye unless otherwise noted.
Key Exclusion Criteria:
All ocular criteria apply to the study eye unless otherwise noted.
11. History of ocular neoplasm. 12. ETDRS BCVA in the fellow eye is worse than 35 letters (Snellen equivalent of 20/200).
13. Female who is pregnant, nursing, or planning to become pregnant, or who is of and not using a reliable means of during the study.
14. Subject is currently participating in or has participated within the last 3 months in any other clinical trial of an drug by ocular or systemic administration.
15. Any concomitant medical or psychological condition that could interfere with study participation or is otherwise not suitable for entry into the study in the opinion of the investigator.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Childbearing potential
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Investigational drug or device
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
EO2002 + topical Ripasudil daily, then reinjection at week 6 + topical Ripasudil daily
Biological: EO2002 · Drug: Ripasudil
EO2002 injection at Day 0 and re-injection at Week 6
Biological: EO2002
Safety and Tolerability of multiple doses of EO2002
Incidence of Treatment-Emergent Adverse Events
Time frame: 32 weeks
Central Corneal Thickness
Changes in CCT compared to baseline
Time frame: 32 weeks
Best Corrected Visual Acuity
Changes in BCVA compared to baseline
Time frame: 32 weeks
Plan to share: No
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Studies of the drug tested here: EO2002
Asociación para Evitar la Ceguera en México