Fatigue Syndrome, Chronic clinical trials
The registry lists 264 studies for Fatigue Syndrome, Chronic across more than 10 countries. 62 are recruiting or about to start. 170 of them are mainly about Fatigue Syndrome, Chronic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Stony Brook University (7) · Haukeland University Hospital (7) · Charite University, Berlin, Germany (6) · Norwegian University of Science and Technology (5) · University of Aarhus (5) · Icahn School of Medicine at Mount Sinai (5) · Oslo University Hospital (5) · University of Alabama at Birmingham (5)
What is being tested here
Drugs under test in Fatigue Syndrome, Chronic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Subgrouping Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Linking the Powerhouses of Cells to the Autonomic Nervous System · Vrije Universiteit Brussel
- Dec 2026Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome · Icahn School of Medicine at Mount Sinai
- Dec 2026Occurrence of Antibodies Cross-reacting With Autoantigens in Primary EBV Infection · University Hospital, Basel, Switzerland
- Dec 2026Photobiomodulation in Chronic Fatigue Syndrome · University of Lahore
- Dec 2026Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent an Exercise Test. · Hôpital Européen Marseille
- Dec 2026Effectiveness and Safety of a Tele-Rehabilitation Program on Fatigue and Related Variables in Chronic Fatigue Syndrome and Post COVID Syndrome · University of Seville
- Dec 2026tVNS in Long COVID-19 · Icahn School of Medicine at Mount Sinai
- Jan 2027A 3-day Course for CFS/ME · Norwegian University of Science and Technology
- Jan 2027Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study · Oxford Brookes University
- Jan 2027Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone · Seattle Institute for Biomedical and Clinical Research
Who these studies take
Of the 44 Fatigue Syndrome, Chronic studies recruiting now, 18 (41%) set no upper age limit and 20 (45%) stop at 75 or younger. 5 (11%) take children under 18. 1 (2%) are for women only and 1 (2%) for men only; 10 (23%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (11%) | 5 (11%) |
| 18 | 39 (89%) | 40 (91%) |
| 30 | 40 (91%) | 40 (91%) |
| 40 | 41 (93%) | 41 (93%) |
| 50 | 42 (95%) | 42 (95%) |
| 65 | 37 (84%) | 36 (82%) |
| 75 | 24 (55%) | 23 (52%) |
| 85 | 19 (43%) | 19 (43%) |
Across all 264 studies, recruiting or not: 63% stop at 75 or younger and 47% at 65; 12% take children; 7% are for women only and 1% for men only; 30% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Fatigue Syndrome, Chronic studies take
Of 78 interventional studies with no phase under Fatigue Syndrome, Chronic, half reached primary completion within 23 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 23 mo11–43 · 78 studies | — | 24 mo11–43 · 73 studies |
| Observational | 44 mo25–79 · 41 studies | — | 44 mo27–79 · 39 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
- Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility StudyNov 5, 2026NCT07874217
Stopped1
- Chronic Fatigue in the Internal Medicine Outpatient Clinic: a Mixed-methods Quantitative and Qualitative StudyTerminatedOct 30, 2026NCT06775262
Newly registered4
- Exploring the Extended Efficacy and Initial Use of RUCONEST® in Managing Neurological Symptoms Linked to Infectious PathogensNov 12, 2026NCT07932002
- Subgrouping Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Linking the Powerhouses of Cells to the Autonomic Nervous SystemNov 9, 2026NCT07925944
- Transcraneal Magnetic Stimulation for Treatment of Non-nociceptive Pain in Chronic DiseasesOct 22, 2026NCT07888673
- Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility StudyOct 14, 2026NCT07874217
Studies
Recruiting first, then most recently updated. Showing 50 of 264. Browse all 264 → or search them.
- Exploring the Extended Efficacy and Initial Use of RUCONEST® in Managing Neurological Symptoms Linked to Infectious PathogensRecruitingNCT07932002Phase 41 country
- Study of the Efficacy and Safety for Rituximab in Myalgia Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)RecruitingNCT06952413Phase 21 country
- Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility StudyRecruitingNCT07874217Not applicable1 country
- ME/CFS Brain Fog: Cognitive Rehabilitation TrialRecruitingNCT07523113Not applicable1 country
- Fareon Open Label Device Clinical TrialEnrolling by invitationNCT07600320Not applicable1 country
- LIFT: Life Improvement TrialRecruitingNCT06366724Phase 21 country
- Low-Dose Naltrexone For ME/CFS: Dose-FindingNot yet recruitingNCT07285473Phase 21 country
- Photobiomodulation in Chronic Fatigue SyndromeRecruitingNCT07546539Not applicable1 country
- RCT of Efficacy and Safety of CP003 on CFS/ME or Post COVID-19 FatigueRecruitingNCT06739720Phase 2/31 country
- Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and EffortRecruitingNCT06472622Early Phase 11 country
- RCT of Mind-body in Long COVID and Myalgic EncephalomyelitisRecruitingNCT06933173Not applicable1 country
- Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)RecruitingNCT07621068Not applicable1 country
- Bao Yuan Tang Extract and Galactooligosaccharides for Sleep RegulationNot yet recruitingNCT07774897Not applicable1 country
- Micro-choice-based Intervention for Multicausal FatigueRecruitingNCT07726082Not applicable1 country
- Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue SyndromeRecruitingNCT07753122Not applicable1 country
- CD19-B Cell Depletion in PAIS-ME/CFS PatientsNot yet recruitingNCT07724834Phase 21 country
- PEM, a Starting Point to Investigate ME/CFSRecruitingNCT077158381 country
- Testosterone Replacement in Male Cancer Survivors With Fatigue and Low TestosteroneRecruitingNCT04049331Phase 21 country
- Photobiomodulation for Chronic Pain and Fatigue in Hypermobile Ehlers-Danlos Syndrome (PBM-SEDh-01)RecruitingNCT076370841 country
- Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 Onset ME/CFS Versus Pre-Pandemic ME/CFS PatientsEnrolling by invitationNCT072567951 country
- Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent an Exercise Test.RecruitingNCT07491315Not applicable1 country
- Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.RecruitingNCT03759522Phase 11 country
- A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFSRecruitingNCT075519991 country
- Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System ImpairmentNot yet recruitingNCT07317401Not applicable1 country
- Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic ConditionsEnrolling by invitationNCT062574201 country
- Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic FatigueRecruitingNCT06170645Not applicable1 country
- Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination SyndromeRecruitingNCT074008481 country
- Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFSRecruitingNCT075291971 country
- Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue SyndromeRecruitingNCT06511050Phase 1/21 country
- Cognitive Performance, Sleep Disturbances and Fatigue in Multiple SclerosisRecruitingNCT074269911 country
- Chronic Infections and Inflammation in ME/CFS: An Observational StudyRecruitingNCT072274411 country
- Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With FibromyalgiaRecruitingNCT07242573Not applicable1 country
- Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal SymptomsNot yet recruitingNCT07409948Not applicable
- Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation ResearchRecruitingNCT048066201 country
- The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis/Chronic Fatigue SyndromeNot yet recruitingNCT07357688Not applicable1 country
- OutreAch MediCal Care for HousEbound Patients With Post-COVID-19 Syndrome or ME/CFS of Any Cause (ACCESS)RecruitingNCT07352254Not applicable1 country
- A 3-day Course for CFS/MERecruitingNCT05236465Not applicable1 country
- Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard CareNot yet recruitingNCT06386133Not applicable
- Internet-based Treatment for Patients Suffering From Severe Functional Somatic DisordersRecruitingNCT05525598Not applicable1 country
- Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFSRecruitingNCT07009691Not applicable1 country
- Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME)RecruitingNCT03773003Not applicable1 country
- The Long COVID-19 Wearable Device StudyRecruitingNCT05741112Not applicable1 country
- Assessment of Exercise Response in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis.RecruitingNCT036750871 country
- The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue SyndromeRecruitingNCT06211062Phase 21 country
- Occurrence of Antibodies Cross-reacting With Autoantigens in Primary EBV InfectionRecruitingNCT051279801 country
- Multi-Center Registry for ME/CFSRecruitingNCT057780061 country
- Effectiveness of Acceptance Commitment Therapy or Micro Breaks in Patients with Chronic Fatigue Syndrome/ Myalgic EncephalomyelitisRecruitingNCT05168124Not applicable1 country
- Quest to Analyze One Thousand Humans MeditatingEnrolling by invitationNCT065833951 country
- Healthy Control Population for PAIS-ME/CFS: Study to Evaluate Possible Biomarkers and Methods for Examination of PAIS-ME/CFS Diagnostics in Healthy VolunteersNot yet recruitingNCT06653712
- A Feasibility Study: Assessing Photobiomodulation in Myalgic EncephalomyelitisEnrolling by invitationNCT06145867Not applicable1 country