An observational study in Encephalomyelitis and Chronic Fatigue Syndrome, sponsored by Mayo Clinic. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-27.
Sponsored by Mayo Clinic · Observational
The purpose of this research is to evaluate the use of a voice-based tool in the diagnosis and management of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
263 studies on the registry are indexed under Fatigue Syndrome, Chronic; 61 are open to participants now.
This study's planned enrollment of 40 is below the median of 150 across 77 observational studies indexed under Fatigue Syndrome, Chronic.
Browse Fatigue Syndrome, Chronic studies →Mayo Clinic is the lead sponsor of 3,269 studies on the registry; 672 are open to participants now.
Of its 452 completed or terminated interventional studies of FDA-regulated products, 321 (71%) have results posted.
Compared within Fatigue Syndrome, Chronic, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Encephalomyelitis. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Participants will be recruited from the Mayo Clinic Division of General Internal Medicine which includes the Fibromyalgia \& Chronic Fatigue Syndrome Clinic, Post-COVID Care Clinic, and Consultative Medicine Clinic.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
Clinically significant
Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Voice Recording
Patients will create 5 - 10 minute voice recordings that include counting, vowel prolongation, alternating speed, and word repetition, every 2 weeks, for a total of 12 weeks. Recordings will be collected using the Visible mobile application, and patients will wear the Visible Armband 2.0 while recording.
Feasibility of Mayo Speech Test (Voice Signatures) for Screening of ME/CFS
Speech data will be analyzed for voice signatures that can be differentiated from people with ME/CFS and those without ME/CFS. data will be analyzed for voice signatures that can be differentiated from people with ME/CFS and those without ME/CFS.
Time frame: 12 weeks
Feasibility of Mayo Speech Test (Voice Signatures) for Monitoring of ME/CFS
Speech data will be analyzed alongside wearable data to assess feasibility of Mayo Speech Test for ME/CFS disease monitoring.
Time frame: 12 weeks
Feasibility of Mayo Speech Test (Voice Signatures) for Severity of ME/CFS
Speech data will be analyzed for voice signatures that can differentiate by severity level within ME/CFS (mild, moderate, severe, very severe).
Time frame: 12 weeks
Plan to share: No
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