An interventional study of Micro-choice-based intervention in Multicausal Fatigue, Fatigue and Post COVID Condition, sponsored by University Hospital, Basel, Switzerland. Recruiting at 1 site in Switzerland. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-08-18.
Sponsored by University Hospital, Basel, Switzerland · Not applicable, Interventional, and Treatment
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Among 32 studies in Fatigue with a site in Switzerland — 6 open to participants now, 8 under way, 1 of them phase 3. Fatigue · Switzerland.
Among the 32 studies in Fatigue with a site in Switzerland, this one is the 14th largest by planned enrollment of the 18 interventional ones that give a count, is one of 4 that started in 2026, is one of 8 with no phase, and was the 30th registered.
2,232 studies on the registry are indexed under Fatigue; 428 are open to participants now.
Browse Fatigue studies →6 of the 32 studies in Fatigue with a site in Switzerland are open now. Recruiting first, the newest first:
Klinik Valens · Sites in Switzerland
Ages 18+
Novartis Pharmaceuticals · Sites in Switzerland, United States, Australia and 17 more countries
Ages 18+
Liliana Barrios · Sites in Switzerland
Ages 18–65 · Healthy volunteers
University of Fribourg · Sites in Switzerland
Healthy volunteers
Insel Gruppe AG, University Hospital Bern · Sites in Switzerland
Ages 18–65
A study can be open while its sites in Switzerland have not opened yet or have stopped. Only those recruiting at a site in Switzerland →
Of the 240 Fatigue studies recruiting now, 111 (46%) set no upper age limit and 99 (41%) stop at 75 or younger; 23 take children under 18; 73 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
32 studies; the count open now beside each. This study's row is marked.
First in 2005; this study’s year is marked. 4 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 24 is below the median of 54 across 1,760 interventional studies indexed under Fatigue.
Median enrollment 69 across the 18 interventional studies, 121 across the 14 observational. Of the 21 that completed or were terminated, 1 (5%) have results posted.
This tab as a report to print or save as PDF → With an account.
3 of 32 have an industry lead sponsor. The 10 most frequent:
University Hospital, Basel, Switzerland is the lead sponsor of 990 studies on the registry; 189 are open to participants now.
University Hospital, Basel, Switzerland has 2 studies filed under Fatigue — fewer than ten, so there is no comparison to draw.
4 of the studies in Fatigue with a site in Switzerland that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07485218University of Applied Sciences and Arts of Southern SwitzerlandMultidimensional Assessment of Fatigability in Older Adults Living in Southern Switzerland and Elderly With Parkinson's Disease | 2026-12 |
| NCT05357781Insel Gruppe AG, University Hospital BernImmunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)? | 2026-12-30 |
| NCT07707453University of FribourgThe COMET Study: a Prospective COhort of MEdical residenTs to Assess Professional, Personal and Psychological Trajectories of Residents in General Internal Medicine | 2026-12-31 |
| NCT07726082University Hospital, Basel, SwitzerlandMicro-choice-based Intervention for Multicausal Fatigue | 2027-08 |
Add all 4 to your calendar (.ics) → With an account.
Among the 32 studies in Fatigue with a site in Switzerland, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This proof-of-concept study aims to evaluate the feasibility, acceptability, and potential benefits of a novel multimodal approach: the micro-choice-based intervention.
The intervention of this study includes a preparation phase, a four-day intensive group treatment, and a follow-up phase to support the integration of new behaviors into daily life. As no comparable program currently exists in Switzerland, this project addresses a significant gap in care. If found to be feasible, the intervention has the potential to improve quality of life, support reintegration into daily and professional activities, and reduce the risk of disability and long-term work incapacity, thereby also contributing to lower healthcare costs.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
- Experiencing persistent fatigue with a significant impact on daily functioning (Chalder Fatigue- Scale bimodal ≥ 4)
Exclusion Criteria:
Are deemed incompatible with group participation during the preparation phase, based on a team assessment. Reasons for exclusion based on group incompatibility include:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Behavioral: Micro-choice-based intervention
The intervention consists of three phases: (1) a preparation phase including a preparatory webinar about the concept of micro-choices; active decision to participate; (2) a concentrated four-day group intervention based on the micro-choice model, delivered by an interdisciplinary team (psychosomatics, internal medicine, physiotherapy, occupational therapy); and (3) a follow-up phase over three weeks, during which participants are supported in integrating behavioral changes into everyday life through digital self-monitoring and an individual follow-up consultation
Retention rate
defined as the percentage of participants who complete all phases of the study. To assess this, the investigators will evaluate: * Dropout rates at different phases of the study: preparation, concentrated intervention and follow up * Completion rates within each phase to identify potential barriers to adherence and engagement
Time frame: up to 6 month
Patient satisfaction
Patient satisfaction will be assessed using the ZUF-8 (Fragebogen zur Messung der Patientenzufriedenheit), the validated German version of the Client Satisfaction Questionnaire (CSQ-8). Items are answered on a 4-point scale. Scores are summed across items once. Some items are reverse scored. Total scores range from 8 to 32, with the higher number indicating greater satisfaction.
Time frame: up to 6 month
Fatigue
Fatigue is assessed by the 11-item Chalder Fatigue Scale (46), e.g. by asking "Do you have difficulty concentrating?". Items are answered on a 4-point scale ranging from 0 = "Better than usual" to 3 = "much worse than usual".
Time frame: up to 6 month
Somatic Symptom Severity
The Patient Health Questionnaire (PHQ-15; 34) assesses somatic symptom severity during the past 4 weeks. Patients are asked how impaired they felt by their symptoms, e.g. back pain. Items are answered on a 3-point scale ranging from 0 = "not bothered at all" to 2 = "bothered a lot".
Time frame: up to 6 month
Somatic Distress
The Somatic Symptom Disorder Questionnaire (SSD-12; 35) assesses psychological features of somatic disorders, e.g. catastrophizing thoughts and health anxiety, e.g. with the statement "I think that my physical symptoms are signs of a serious illness". Items are answered on a 5-point scale ranging from 0 = "never" to 4 = "very often".
Time frame: up to 6 month
Depressive Symptoms
The 8-item Patient Health Questionnaire Depression Scale (PHQ-8; 36) assesses the severity of depressive disorders. Patients are asked if in the past weeks, they were bothered by a problem, e.g. by having little interest or pleasure in doing things. Items are answered on a 4-point scale ranging from 0 = "not at all" to 3 = "nearly every day".
Time frame: up to 6 month
Anxiety Symptoms
Anxiety is assessed with the Generalized Anxiety Disorder Questionnaire (GAD-7; 44). It assesses if the patient was bothered by complaints related to anxiety during the past 2 weeks, e.g. by asking about having trouble to relax. Items are answered on a 4-point Likert scale ranging from 0 = "not at all" to 3 = "nearly every day".
Time frame: up to 6 month
Functional capacity
The World Health Organization Disability Assessment Schedule (WHODAS 2.0) assesses and classifies disability due to health problems during the past 4 weeks. This study will utilize the 12-item version. An example item would be "In the past 4 weeks, how much difficulty did you have in walking a long distance such as a kilometer (or equivalent)?". Items are answered on a 5-point scale ranging from 0 = "none" to 4 = "extreme or cannot do".
Time frame: up to 6 month
Change in Quality of life
As a measure of life quality, the EuroHIS Quality-of-Life-8 (QOL-8; 42) will be used. This 8-item instrument assesses quality of life and perceived health during the past 4 weeks, e.g. by asking "Do you have enough energy for everyday life?". Items are answered on a 5-point scale, with wording differing between questions (e.g., from "very dissatisfied" to "very satisfied").
Time frame: up to 6 month
Work ability
assessed via questionnaires: at full work, at partial work, not at work.
Time frame: up to 6 month
Work and Social Adjustment
Work and Social Adjustment Scale (WSAS;(38) ) assesses functional impairment attributable to a health condition in key areas of daily life, including work, home management, social and private leisure activities, and close relationships. An example item is "Because of my illness, my ability to work is impaired." Items are rated on a 9-point scale ranging from 0 = "not at all impaired" to 8 = "very severely impaired". Higher total scores indicate greater functional impairment.
Time frame: up to 6 months
Plan to share: No
No publications or documents are linked to this record.
Started Aug 2026 (actual). Primary completion is estimated for Aug 2027, 12 months after the start.
Of 936 non-industry interventional studies with no phase under Fatigue, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 27. This study's planned 12 months is close to that.
Counting every sponsor, half of 989 studies reached it within 11 months; a quarter within 5 and three quarters within 27.
How these figures are worked out, and which studies are left out of them.
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University Hospital, Basel, Switzerland →