Enterocolitis, Necrotizing clinical trials
The registry lists 228 studies for Enterocolitis, Necrotizing across more than 10 countries. 44 are recruiting or about to start. 146 of them are mainly about Enterocolitis, Necrotizing (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
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Status
Who runs them
Ain Shams University (6) · University of Utah (6) · Per Torp Sangild (5) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (5) · Coordinación de Investigación en Salud, Mexico (4) · Zekai Tahir Burak Women's Health Research and Education Hospital (4) · Assiut University (4) · The Hospital for Sick Children (4)
What is being tested here
Drugs under test in Enterocolitis, Necrotizing studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- May 2027Multi-strain Probiotics to Prevent Necrotizing Enterocolitis in Very Preterm Infants · Phase 3 · University of Calgary
- Dec 2026Early Predictors of Necrotizing Enterocolitis in Neonates · Nationwide Children's Hospital
- Jan 2027Mechanisms Affecting the Gut of Preterm Infants Receiving Blood Transfusion With Different Enteral Feed Interventions · Imperial College Healthcare NHS Trust
- Mar 2027A Cohort Study of the Intestinal Microbiota of Premature Infants · University of California, Davis
- Mar 2027WithHolding Enteral Feeds Around Blood Transfusion (International) · IWK Health Centre
- Apr 2027Pattern And Outcome Of Neonatal Gastrointestinal Emergencies In Assiut University Children Hospital · Assiut University
- May 2027Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns · The First Hospital of Jilin University
- Jun 2027Predictive Diagnosis of Ulcero-Necrotizing EnteroColitis in Premature Babies Using an Artificial Intelligence Approach Based on Early Analysis of the Fecal Microbiota · University Hospital, Clermont-Ferrand
- Jun 2027Effect of Rectal Administration of Breast Milk on Gut Microbiota in Preterm Infants · Zekai Tahir Burak Women's Health Research and Education Hospital
- Sep 2027Fecal Calprotectin in Breastfed vs Formula-Fed Preterm Infants and NEC · Assiut University
Who these studies take
Of the 26 Enterocolitis, Necrotizing studies recruiting now, 4 (15%) set no upper age limit and 22 (85%) stop at 75 or younger. 26 (100%) take children under 18. 2 (8%) are for women only and 0 (0%) for men only; 3 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (27%) | 5 (19%) |
| 18 | 7 (27%) | 5 (19%) |
| 30 | 7 (27%) | 5 (19%) |
| 40 | 7 (27%) | 5 (19%) |
| 50 | 5 (19%) | 5 (19%) |
| 65 | 5 (19%) | 5 (19%) |
| 75 | 4 (15%) | 4 (15%) |
| 85 | 4 (15%) | 4 (15%) |
Across all 228 studies, recruiting or not: 84% stop at 75 or younger and 84% at 65; 97% take children; 3% are for women only and 0% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Enterocolitis, Necrotizing studies take
Of 39 observational studies under Enterocolitis, Necrotizing, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 39 mo16–59 · 33 studies | — | — |
| Observational | 29 mo19–115 · 39 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting4
- Multidimensional Dynamic Early Warning System for Neonatal Necrotizing Enterocolitis: A Multicenter Clinical StudyNov 6, 2026NCT07545993
- Fecal Microbiota Transplantation (FMT) as a Prophylaxis of Necrotizing Enterocolitis (NEC) - Clinical StudyNov 5, 2026NCT06333405
- Effects of Enteral Feeding Regimens on NEC, Mortality, and Neurodevelopment in Very Preterm InfantsOct 26, 2026NCT07045844
- The Correlation Between Red Cell Transfusion and Complications of PrematurityOct 22, 2026NCT07123948
Studies
Recruiting first, then most recently updated. Showing 50 of 228. Browse all 228 → or search them.
- Study of the Influence of Intraperitoneal Insufflation of CO2 by Laparoscopy on the Short-term Evolution of Premature Infants With Ulcerative Necrotizing EnterocolitisRecruitingNCT05882448Not applicable1 country
- Multidimensional Dynamic Early Warning System for Neonatal Necrotizing Enterocolitis: A Multicenter Clinical StudyRecruitingNCT075459931 country
- Fecal Microbiota Transplantation (FMT) as a Prophylaxis of Necrotizing Enterocolitis (NEC) - Clinical StudyRecruitingNCT06333405Not applicable1 country
- Effects of Enteral Feeding Regimens on NEC, Mortality, and Neurodevelopment in Very Preterm InfantsRecruitingNCT07045844Not applicable1 country
- The Correlation Between Red Cell Transfusion and Complications of PrematurityRecruitingNCT071239481 country
- Gut Permeability and Microbiome in Preterm InfantsRecruitingNCT07667049Phase 11 country
- WithHolding Enteral Feeds Around Blood Transfusion (International)RecruitingNCT05213806Not applicable2 countries
- Fecal Calprotectin in Breastfed vs Formula-Fed Preterm Infants and NECNot yet recruitingNCT07810543
- Mucous Fistula Refeeding Reduces the Time From Enterostomy Closure to Full Enteral Feeds ("MUC-FIRE" Trial)RecruitingNCT03469609Not applicable3 countries
- A Feasibility Study to Evaluate Safety and Probable Benefit of the Eclipse XL1 System for Distraction Enterogenesis in Adult and Pediatric Patients With Short Bowel SyndromeRecruitingNCT05535361Not applicable1 country
- Neonatal Laparotomy - A Trial Investigating the Impact of Location of SurgeryNot yet recruitingNCT07754435Not applicable
- Diagnostic, Therapeutic and Reproductive Aspects of Patients With Mullerian AnomaliesRecruitingNCT046278181 country
- Delayed Versus Immediate Cord Clamping in Preterm BirthRecruitingNCT07699666Not applicable1 country
- Investigation of Allergen Sensitization in Newborn Babies Diagnosed With Necrotizing Enterocolitis.Not yet recruitingNCT07562009Not applicable
- Effect of Rectal Administration of Breast Milk on Gut Microbiota in Preterm InfantsNot yet recruitingNCT07558499Not applicable
- Pattern And Outcome Of Neonatal Gastrointestinal Emergencies In Assiut University Children HospitalNot yet recruitingNCT07526636
- Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC)RecruitingNCT06315738Phase 1/21 country
- Predictive Diagnosis of Ulcero-Necrotizing EnteroColitis in Premature Babies Using an Artificial Intelligence Approach Based on Early Analysis of the Fecal MicrobiotaRecruitingNCT06727877Not applicable1 country
- Mechanisms Affecting the Gut of Preterm Infants Receiving Blood Transfusion With Different Enteral Feed InterventionsRecruitingNCT071916781 country
- Health-Related Quality-of-Life and Household Financial and Wellbeing Impacts of Prematurity and Necrotising Enterocolitis (NEC).RecruitingNCT071923931 country
- Study of Normal Intestinal Development and Disease in Premature and Term NeonatesRecruitingNCT066811291 country
- Long-term Nutritional Impact of Necrotizing Enterocolitis in Premature Newborns.Enrolling by invitationNCT074908341 country
- Characterization of Extracellular Vesicles From the Cord Blood of Extremely Preterm New Borns and Their Correlation With Severe Morbidity and MortalityRecruitingNCT072736431 country
- Administration of Extracellular Vesicles From Donor Human Milk in Preterm InfantsRecruitingNCT074020831 country
- NETs: Protection or Harm in Neonatal Inflammation or InfectionRecruitingNCT007478511 country
- Calprotectin and Gut Disease StudyNot yet recruitingNCT07112794
- Application of Transcriptome Sequencing Combined With Family-Based Whole Genome Sequencing in Improving Precise Diagnosis of Critically Ill Newborns in Northeast ChinaNot yet recruitingNCT06990334
- The Intestinal Innate Immune System in Newborns. Development and Inflammation in Health and DiseaseRecruitingNCT060924631 country
- Do Probiotics Reduce The Risk Of Severe Necrotising Enterocolitis (NEC) In Infants Born Before 32 Weeks Gestation?Enrolling by invitationNCT064229881 country
- Multi-strain Probiotics to Prevent Necrotizing Enterocolitis in Very Preterm InfantsNot yet recruitingNCT06810154Phase 31 country
- Necrotizing Enterocolitis and Bowel Perforation in Very Preterm Infants - Long-term Follow upNot yet recruitingNCT067575821 country
- PrePhage - Faecal Bacteriophage Transfer for Enhanced Gastrointestinal Tract Maturation in Preterm InfantsRecruitingNCT05272579Early Phase 11 country
- Impact of Standardized Skin-to-Skin Care on Clinical Outcomes in Infants Born ≤ 32 Weeks: A Multicenter StudyRecruitingNCT06672913Not applicable1 country
- Necrotizing EnterocolitiesNot yet recruitingNCT06632041
- Spectral Analysis of Bowel Sounds in Preterm Babies of Less Than 32 Weeks of Amenorrhea (WA) as Predictive Factor of EnterocolitisRecruitingNCT05544097Not applicable1 country
- Qualitative Study of Surgeons With Prospective Patient Follow-upRecruitingNCT060326761 country
- Intestinal Perfusion After Feeding in Preterm and Term InfantsNot yet recruitingNCT063193261 country
- Diagnostic, Therapeutic and Reproductive Aspects of Patients With Mullerian Anomalies (MULAN)RecruitingNCT047325461 country
- The Effect of Probiotics Added to the Mother's Diet on Preterm BabiesNot yet recruitingNCT06118801Not applicable
- Probiotic Supplementation in Extremely Preterm Infants in ScandinaviaRecruitingNCT05604846Not applicable1 country
- PUFAs in Preterm InfantsNot yet recruitingNCT06045130
- Human Milk-derived Fortification in Preterm InfantsNot yet recruitingNCT05228847Not applicable1 country
- Enteral Feeding in Infants With Duct Dependant Lesions.Not yet recruitingNCT05117164Not applicable1 country
- Treatment of Classic Mid-trimester PPROM by Means of Continuous AmnioinfusionNot yet recruitingNCT04696003Phase 31 country
- RIC-NEC Randomized Controlled TrialCompletedNCT05279664Phase 22 countries
- Early Predictors of Necrotizing Enterocolitis in NeonatesActive, not recruitingNCT032108311 country
- Cohort of Premature Newborns for Charaterization of the Digestive Microbiota in Ulcerative Necrotizing Enterocolitis in Premature InfantsCompletedNCT04972734Not applicable1 country
- Assessing the Efficacy of Probiotics in Prevention of NEC in Preterm BabiesActive, not recruitingNCT07233382Not applicable1 country
- Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm BabiesCompletedNCT077653291 country
- RBC Irradiation, Anemia and Gut InjuryCompletedNCT027416481 country