An observational study in Premature Birth, Neonatal Hypoglycemia and Maternal Infection During Pregnancy, sponsored by Stella Maris Women and Children Hospital. Completed at 1 site in Indonesia. Open to participants aged 26 Weeks to 36 Weeks. Per ClinicalTrials.gov, last updated 2026-08-14.
Sponsored by Stella Maris Women and Children Hospital · Observational
The goal of this observational study was to compare two doses of dexamethasone given to pregnant women at risk of preterm birth. Dexamethasone is a medicine used before birth to help a baby's lungs mature.
This study looked at preterm babies born between 26 and 36 weeks of pregnancy. Researchers compared babies whose mothers received dexamethasone 12 mg every 12 hours for 48 hours with babies whose mothers received dexamethasone 6 mg every 12 hours for 48 hours.
The main questions this study aimed to answer were:
Researchers reviewed medical records from Stella Maris Women's and Children's Hospital from January 2018 to January 2023. They looked at neonatal outcomes, including breathing support, respiratory distress syndrome, length of NICU stay, low blood sugar in babies, infection in mothers, and developmental problems at 24 months.
Preterm infants treated at the Neonatal Intensive Care Unit of Stella Maris Women's and Children's Hospital, Medan, Indonesia, from January 2018 to January 2023. Data were obtained retrospectively from hospital medical records.
Exclusion Criteria:
Drug: Dexamethasone 12 mg Every 12 Hours
Drug: Dexamethasone 6 mg Every 12 Hours
Pregnant women at risk of preterm birth received antenatal dexamethasone 12 mg every 12 hours for 48 hours for fetal lung maturation. Neonatal outcomes were compared with those of infants whose mothers received the lower-dose dexamethasone regimen.
Also known as: Antenatal Dexamethasone, Antenatal Corticosteroid
Pregnant women at risk of preterm birth received antenatal dexamethasone 6 mg every 12 hours for 48 hours for fetal lung maturation. This regimen was compared with dexamethasone 12 mg every 12 hours.
Also known as: Antenatal Dexamethasone, Antenatal Corticosteroid
Duration of Mechanical Ventilation Support
Number of days preterm infants required mechanical ventilation support after birth. This outcome was compared between infants whose mothers received dexamethasone 12 mg every 12 hours and infants whose mothers received dexamethasone 6 mg every 12 hours.
Time frame: From initiation of mechanical ventilation until discontinuation of mechanical ventilation, assessed up to NICU discharge or 12 weeks after birth, whichever occurred first
Length of Stay in the Neonatal Intensive Care Unit (LOS-NICU)
Number of days the infant stayed in the Neonatal Intensive Care Unit, also called the NICU.
Time frame: From NICU admission until NICU discharge, assessed up to 12 weeks after birth
Need for Respiratory Support
Number of infants who required respiratory support after birth, including mechanical ventilation, continuous positive airway pressure, or nasal cannula.
Time frame: From birth until NICU discharge, assessed up to 12 weeks after birth
Neonatal Respiratory Distress Syndrome
Number of infants diagnosed with neonatal respiratory distress syndrome after birth.
Time frame: From birth until NICU discharge, assessed up to 12 weeks after birth
Neonatal Sepsis
Number of infants diagnosed with neonatal sepsis.
Time frame: From birth until NICU discharge, assessed up to 12 weeks after birth
Necrotizing Enterocolitis
Number of infants diagnosed with necrotizing enterocolitis.
Time frame: From birth until NICU discharge, assessed up to 12 weeks after birth
Neonatal Intraventricular Hemorrhage
Number of infants diagnosed with intraventricular hemorrhage.
Time frame: From birth until NICU discharge, assessed up to 12 weeks after birth
Neonatal Hypoglycemia
Number of infants diagnosed with low blood sugar after birth.
Time frame: From birth until NICU discharge, assessed up to 12 weeks after birth
Neurodevelopmental Disorders at 24 Months
Number of infants with neurodevelopmental disorders identified at 24 months of age.
Time frame: At 24 months of age after birth
Maternal Infection
Number of mothers diagnosed with infection after receiving antenatal dexamethasone.
Time frame: From first dose of antenatal dexamethasone until maternal hospital discharge, assessed up to 7 days after delivery
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Stella Maris Women and Children Hospital