Desmoplastic Small Round Cell Tumor clinical trials
The registry lists 59 studies for Desmoplastic Small Round Cell Tumor across more than 10 countries. 14 are recruiting or about to start. 17 of them are mainly about Desmoplastic Small Round Cell Tumor (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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· Enrollment: 300 → 450 participants
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Who runs them
Memorial Sloan Kettering Cancer Center (9) · National Cancer Institute (NCI) (6) · Children's Oncology Group (4) · M.D. Anderson Cancer Center (3) · Seattle Children's Hospital (2) · Mayo Clinic (2) · Societe Internationale d'Oncologie Pediatrique (2) · European Organisation for Research and Treatment of Cancer - EORTC (2)
What is being tested here
Drugs under test in Desmoplastic Small Round Cell Tumor studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Alkylating agents 1 open · Tyrosine kinase inhibitors (TKIs) 5 · Angiogenesis inhibitors 3 · Antimitotic agents 3 · Antimetabolites 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Mar 2027B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR) · St. Jude Children's Research Hospital
- Jun 2027Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and Sarcomas · Cellectar Biosciences, Inc.
- Jul 2027A Study of the Drug I131-Omburtamab in People With Desmoplastic Small Round Cell Tumors and Other Solid Tumors in the Peritoneum · Memorial Sloan Kettering Cancer Center
- Aug 2027Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor · Memorial Sloan Kettering Cancer Center
- Oct 2027Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor · University Hospital Heidelberg
Who these studies take
Of the 12 Desmoplastic Small Round Cell Tumor studies recruiting now, 4 (33%) set no upper age limit and 8 (67%) stop at 75 or younger. 9 (75%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (42%) | 5 (42%) |
| 18 | 12 (100%) | 12 (100%) |
| 30 | 10 (83%) | 10 (83%) |
| 40 | 9 (75%) | 9 (75%) |
| 50 | 8 (67%) | 8 (67%) |
| 65 | 6 (50%) | 6 (50%) |
| 75 | 5 (42%) | 5 (42%) |
| 85 | 4 (33%) | 4 (33%) |
Across all 59 studies, recruiting or not: 53% stop at 75 or younger and 49% at 65; 78% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 59. Browse all 59 → or search them.
- Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell TumorRecruitingNCT04616560Phase 21 country
- Clinical Study in Adult and Young Adult Patients With Advanced Desmoplastic Small Round Cell Tumor (DSRCT) ISG-TULIPSRecruitingNCT07328425Phase 22 countries
- EWSR1 Immunotherapy in Ewing Sarcoma and DSRCTNot yet recruitingNCT07695311Phase 11 country
- Lurbinectedin in FET-Fused TumorsRecruitingNCT05918640Phase 1/21 country
- Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid TumorsRecruitingNCT06625190Phase 1/21 country
- B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)RecruitingNCT04897321Phase 11 country
- Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory SarcomasRecruitingNCT06709495Phase 1/21 country
- Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma GroupRecruitingNCT03967834Not applicable1 country
- Registry to Collect Health Information About Desmoplastic Small Round Cell TumorRecruitingNCT046903741 country
- IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS)RecruitingNCT06849986Phase 21 country
- MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue SarcomaRecruitingNCT06277154Phase 21 country
- Safety and Efficacy of CAR-T Cell Therapy for Relapsed/refractory Neuroblastoma and Desmoplastic Small Round Cell Tumors: a Single-arm, Open-label Trial.RecruitingNCT06836505Phase 1/21 country
- Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell TumorRecruitingNCT06456359Phase 21 country
- A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577)Enrolling by invitationNCT05266196Phase 1/21 country
- EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT03618381Phase 11 country
- Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and SarcomasActive, not recruitingNCT03478462Phase 13 countries
- Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell TumorActive, not recruitingNCT01189643Early Phase 11 country
- Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell TumorsCompletedNCT01946529Phase 21 country
- CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell TumorCompletedNCT04145349Phase 1/27 countries
- A Study of the Drug I131-Omburtamab in People With Desmoplastic Small Round Cell Tumors and Other Solid Tumors in the PeritoneumActive, not recruitingNCT04022213Phase 21 country
- Tazemetostat Expanded Access Program for Adults With Solid TumorsNo longer availableNCT03874455
- B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young AdultsActive, not recruitingNCT04483778Phase 11 country
- Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young AdultsTerminatedNCT04530487Phase 21 country
- Study of High Dose Intravenous (IV) Ascorbic Acid in Measurable Solid Tumor DiseaseWithdrawnNCT01125449Phase 21 country
- A Study of the Drugs Prexasertib, Irinotecan, and Temozolomide in People With Desmoplastic Small Round Cell Tumor and RhabdomyosarcomaCompletedNCT04095221Phase 1/21 country
- Heated Intra-peritoneal Chemotherapy with Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric PatientsTerminatedNCT04213794Early Phase 11 country
- Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal CancerCompletedNCT00445965Phase 21 country
- Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid TumorsTerminatedNCT04901806Phase 111 countries
- Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal CancerTerminatedNCT00089245Phase 11 country
- Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related SarcomasActive, not recruitingNCT03600649Phase 11 country
- Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue SarcomaCompletedNCT009192697 countries
- Trial of Nab-paclitaxel in Patients With Desmoid Tumors and Multiply Relapsed/Refractory Desmoplastic Small Round Cell Tumors and Ewing SarcomaCompletedNCT03275818Phase 21 country
- Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid TumorsCompletedNCT02982941Phase 11 country
- Gemcitabine With or Without Pazopanib in Treating Patients With Refractory Soft Tissue SarcomaCompletedNCT01532687Phase 21 country
- Pilot Study of Hyperthermic Peritoneal Perfusion (HIPEC) for Adolescent and Young Adults With Desmoplastic Small Round Cell TumorCompletedNCT01277744Phase 21 country
- Combination Chemotherapy in Treating Patients With SarcomaCompletedNCT00662233Early Phase 11 country
- Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic SarcomaCompletedNCT01154452Phase 1/21 country
- Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid TumorsTerminatedNCT00003926Phase 11 country
- A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial CarcinomaStatus unknownNCT02982486Phase 2
- French National Registry of Rare Peritoneal Surface MalignanciesStatus unknownNCT028341691 country
- Stem Cell Transplantation in Patients With High-Risk and Recurrent Pediatric SarcomasCompletedNCT00043979Phase 21 country
- Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1CompletedNCT01430637
- Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue SarcomasCompletedNCT015670461 country
- Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue SarcomaCompletedNCT00720174Phase 11 country
- Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent SarcomasCompletedNCT00474994Phase 21 country
- Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid TumorsCompletedNCT00024258Phase 21 country
- Imatinib Mesylate in Treating Patients With Relapsed or Refractory Solid Tumors of ChildhoodCompletedNCT00030667Phase 21 country
- Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue SarcomaTerminatedNCT01189253Phase 2/313 countries
- Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue SarcomaCompletedNCT00002898Phase 31 country
- Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal TumorsCompletedNCT00025441Phase 23 countries