An observational study in Cluster Headache, sponsored by Leiden University Medical Center. Completed at 1 site in Netherlands. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-05-13.
Sponsored by Leiden University Medical Center · Observational
Since there is conflicting and insufficient data regarding CH personality and addictive behaviour, the investigators will investigate risk- and reward seeking behaviour in people with cluster headache. If an increased tendency towards this behaviour is shown, it will add to the clinical knowledge of cluster headache and possible lead to insights in a common biological susceptibility.
Cluster headache is a severe primary headache disorder. In clinical anecdotes, people with cluster headache frequently report use of tobacco and illicit drugs. Furthermore, addictive behaviours and tattoos are considered to be more common in people with cluster headache than in the general population. The causality of these associations remains unclear. A common biological susceptibility has been proposed, predisposing people to both addictive behaviour and cluster headache. On the other hand, a role of illicit drug exposure in cluster headache pathophysiology has been suggested. The increased use of tobacco and illicit drugs could also reflect attempts to treat cluster headache attacks. In this explorative study the investigators will assess both subjective and objective measures reflecting addictive behaviour and risk- and reward seeking in cluster headache. This will add to the clinical knowledge of cluster headache and possible lead to insights in a common biological susceptibility.
123 studies on the registry are indexed under Cluster Headache; 26 are open to participants now.
This study's enrollment of 140 is above the median of 68 across 32 observational studies indexed under Cluster Headache.
Browse Cluster Headache studies →Leiden University Medical Center is the lead sponsor of 334 studies on the registry; 110 are open to participants now.
Counted across the registry records on this site, refreshed daily.
People with episodic (n=35) and chronic cluster headache (n=35) will be recruited from the Neurology outpatient clinic of Leiden University Medical Centre. Migraineurs (n=35) will be recruited from the LUMINA pool from people with migraine who have previously expressed interest in being contacted for future studies. Healthy controls (n=35) will be recruited from a pool of prior research-study participants, who have previously expressed interest in being contacted for future studies. We aim to achieve a 3:1 male:female ratio.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients diagnosed according to ICHD3 criteria with episodic cluster headache
Diagnostic Test: BART Task
Patients diagnosed according to ICHD3 criteria with chroniccluster headache
Diagnostic Test: BART Task
Patients diagnosed according to ICHD3 criteria with migraine (MA and MO)
Diagnostic Test: BART Task
Healthy controls, sex- and age-matched without current diagnosis of headache disorder
Diagnostic Test: BART Task
The Zuckerman's Sensation Seeking Scale version-V (SSS-V) - Four-factor score, The Barret Impulsiveness Scale (BIS), Gormally's Binge Eating Scale (BES), The World Health Organization-developed AUDIT (Alcohol Use Disorders Identification Test) screen, The CAGE questionnaire for substance abuse-adapted to include drugs, Gamblers Anonymous's 20 Questions (GA20), Hospital Anxiety and Depression Scale (HADS)
Also known as: Questionnaires
Difference in mean total score on the Zuckerman Sensation Seeking Scale between groups
Between group difference
Time frame: One time-point
Difference in mean total number of pumps during second trial between groups
Between group difference
Time frame: One time-point
Difference in mean scores on the array of psychometric tests between groups
Between group difference
Time frame: One time-point
Difference in mean scores on the BART between groups and between the first and second BART within groups
Average # of pumps, Exploded Balloons
Time frame: One time-point
Ran from Apr 2019 to primary completion in Jan 2022, 32 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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