Cardiac Output, Low clinical trials
The registry lists 99 studies for Cardiac Output, Low across more than 10 countries. 15 are recruiting or about to start. 64 of them are mainly about Cardiac Output, Low (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Medical University of Warsaw (3) · Innogene Kalbiotech Pte. Ltd (2) · University Hospital Birmingham (2) · Università Vita-Salute San Raffaele (2) · Klinikum Ludwigshafen (2) · University of Iowa (2) · Karolinska Institutet (2) · Medical University of Vienna (2)
What is being tested here
Drugs under test in Cardiac Output, Low studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dobutamine | 1 | 0 | 2 |
| Landiolol | 1 | 0 | 1 |
| Simendan | 0 | 3 | 8 |
| Milrinone | 0 | 2 | 4 |
| Epinephrine | 0 | 1 | 2 |
| Perhexiline | 0 | 2 | 2 |
| Nitric Oxide | 0 | 1 | 1 |
| Bupivacaine | 0 | 0 | 1 |
| Hydrocortisone | 0 | 0 | 1 |
| Losartan | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Nov 2026Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery · AHEPA University Hospital
- Dec 2026Correlation of Cardiac Index Measured by the PRAM Method With NIRS and Lactate Levels in Pediatric Aortic Coarctation Surgery · Konya City Hospital
- Dec 2026Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO Patients · Medical University of Vienna
- Jan 2027Cardiac Cycle Efficiency and Vasoactive-Inotropic Support After Cardiac Surgery · Bursa City Hospital
- Jun 2027Landiolol in Mitral Valve Surgery · Università Vita-Salute San Raffaele
Who these studies take
Of the 10 Cardiac Output, Low studies recruiting now, 4 (40%) set no upper age limit and 4 (40%) stop at 75 or younger. 5 (50%) take children under 18. 1 (10%) are for women only and 0 (0%) for men only; 2 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (40%) | 4 (40%) |
| 18 | 7 (70%) | 6 (60%) |
| 30 | 7 (70%) | 6 (60%) |
| 40 | 7 (70%) | 6 (60%) |
| 50 | 6 (60%) | 6 (60%) |
| 65 | 6 (60%) | 6 (60%) |
| 75 | 6 (60%) | 6 (60%) |
| 85 | 6 (60%) | 6 (60%) |
Across all 99 studies, recruiting or not: 30% stop at 75 or younger and 26% at 65; 30% take children; 4% are for women only and 0% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Cardiac Output, Low studies take
Of 22 observational studies under Cardiac Output, Low, half reached primary completion within 22 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 11 mo2–34 · 12 studies | — | — |
| Observational | 22 mo12–34 · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- Evaluating Fluid Responsiveness in ICU Patients Using VTI and Trendelenburg PositioningWithdrawnNov 2, 2026NCT06418022
Newly registered1
- Cardiac Cycle Efficiency and Vasoactive-Inotropic Support After Cardiac SurgeryNov 9, 2026NCT07926360
Studies
Recruiting first, then most recently updated. Showing 50 of 99. Browse all 99 → or search them.
- Cardiac Cycle Efficiency and Vasoactive-Inotropic Support After Cardiac SurgeryRecruitingNCT079263601 country
- Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO PatientsRecruitingNCT044459091 country
- Performance of Carbon Dioxide (CO2)-Derived Parameters in Predicting Low Cardiac Output SyndromeRecruitingNCT077703861 country
- Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac SurgeryRecruitingNCT07770269Not applicable1 country
- Correlation of Cardiac Index Measured by the PRAM Method With NIRS and Lactate Levels in Pediatric Aortic Coarctation SurgeryNot yet recruitingNCT075684311 country
- Landiolol in Mitral Valve SurgeryRecruitingNCT06793670Phase 41 country
- Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early PregnancyRecruitingNCT047557641 country
- Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in ChildrenRecruitingNCT067547091 country
- Can Perfusion Index and Cerebral Oxygen Saturation Trends Predict Low Cardiac Output in Pediatric Cardiovascular SurgeriesNot yet recruitingNCT06759506
- COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG WearableEnrolling by invitationNCT067635491 country
- Non-invasive Continuous Cardiac Output Monitoring in Preterm Infants StudyRecruitingNCT040641771 country
- Hemodynamic Parameters Assessment; Invasive Versus NoninvasiveNot yet recruitingNCT06198621
- Evaluation of Hemodynamic and Ventilatory Effects of Negative Pressure VentilationRecruitingNCT060889661 country
- Dobutamine Versus Milrinone in Management of Critically Ill Low Cardiac Output Pediatric Patients at Cairo University Children's HospitalNot yet recruitingNCT05999487Not applicable1 country
- Outcome of Patients Treated With IABPRecruitingNCT044058561 country
- The Effect of Semi Fowler 30' Right Lateral on Cardiac Output in Acute Heart FailureCompletedNCT06039397Not applicable1 country
- Evaluating Fluid Responsiveness in ICU Patients Using VTI and Trendelenburg PositioningWithdrawnNCT06418022Not applicable1 country
- Post-Induction Low Cardiac Output Syndrome in Coronary Artery Bypass Graft SurgeryActive, not recruitingNCT078106211 country
- Patients With Low Cardiac Output Syndrome Undergoing Local Dental AnesthesiaCompletedNCT06355882Not applicable1 country
- Comparison of Allows Measurement of Cardiac Output Between Clearsight System and Transpulmonary ThermodilutionCompletedNCT027287911 country
- Reliability of a New Pulse Contour Technique for Diagnosing an Increase in Stroke Volume During a Fluid Challenge for Hemodynamic Optimization in Patients Scheduled for High-risk Abdominal Surgery: Comparison With Transthoracic Echocardiography: COMPARE StudyCompletedNCT048716201 country
- Intraoperative Global Longitudinal Strain and Global Longitudinal Strain Rate as Predictors of Unfavorable Outcome in On-Pump Mitral SurgeryCompletedNCT040453401 country
- Perioperative Monitoring of Cardiac Surgery Patients With the Vitalstream Physiological MonitorCompletedNCT05905536Not applicable1 country
- Atrial Natriuretic Peptide in Assessing Fluid StatusCompletedNCT05070819Not applicable1 country
- Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection FractionCompletedNCT02433379Not applicable13 countries
- Validation of Capnodynamic Assessment of Mixed Venous Oxygen SaturationCompletedNCT048856991 country
- Evaluation of the Impact of Ejection Fraction on Clinical Outcomes in Patients Undergoing Cardiovascular SurgeryCompletedNCT064686571 country
- Myocardial Effects of NIV in OHS PatientsCompletedNCT06486129Not applicable1 country
- Nitric Oxide During Bypass for Arterial Switch OperationCompletedNCT03661385Phase 34 countries
- Gap CO2 in Septic Patient to Predict Cardiomyopathy SepticCompletedNCT063267621 country
- Hemodynamic Monitoring in Liver Transplant With VEnaRt Cardiac Output Versus Swan-Ganz Catheter (VERO Study)CompletedNCT048250151 country
- Comparison of Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers in Major Abdominal Surgery PatientsCompletedNCT05365113Not applicable1 country
- Hemodynamic Survey Cardiac Surgical ScenariosCompletedNCT02529033
- The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic PerformanceStatus unknownNCT05492968Phase 41 country
- Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass GraftingStatus unknownNCT05514652Not applicable1 country
- Comparing Cardiac Output Measurements Using a Wearable, Wireless, Non-invasive PPG-Based Device to a Swan Ganz CatheterCompletedNCT049551841 country
- Methoxyflurane and Fentanyl in LBNPCompletedNCT04641949Phase 41 country
- Use of a Mini-fluid Bolus to Identify Fluid ResponsivenessWithdrawnNCT03058653Not applicable
- Liberal Versus Restrictive Use of Dobutamine in Cardiac SurgeryCompletedNCT02361801Phase 31 country
- Fractional Spinal Anesthesia and Systemic Hemodynamics in Frail Elderly Hip Fracture Patients.CompletedNCT05101291Not applicable1 country
- Comparison Studies Comparing Hemodynamic Parameters Provided by the Caretaker Against Respective Gold Standard ReferencesStatus unknownNCT050357191 country
- FranceLEVO - Zimino Registry (FZR)CompletedNCT042524041 country
- Comparison Between NICOM-Cheetah and Flotrac-Vigileo for Cardiac Output Monitoring.TerminatedNCT033947681 country
- Real-time Continuous Cardiac Output MeasurementsStatus unknownNCT04774978Not applicable
- Autologous Umbilical Cord Blood Treatment of Neonate With CHDStatus unknownNCT03558269Phase 1/21 country
- Exogenous Ketones for Acutely Decompensated HEart FailureStatus unknownNCT04698005Phase 31 country
- Validity of Cardiac Output Measurement Using Niccomo Device After Cardiac SurgeryStatus unknownNCT046435091 country
- Echo FLOW Versus (Non-)Invasive HaemodynamicsCompletedNCT045937971 country
- Non-Invasive Cardiac Output Monitor in ChildrenCompletedNCT038696061 country
- Spanish Randomized Clinical Trial to Compare Levosimendan Versus Placebo in Postoperative Cardiac Surgery (SPARTANS)Status unknownNCT04179604Phase 2/31 country