An observational study in Low Cardiac Output Syndrome Bypass Children, sponsored by University Hospital, Lille. Recruiting at 1 site in France. Open to participants aged Up to 17 Years. Per ClinicalTrials.gov, last updated 2026-09-09.
Sponsored by University Hospital, Lille · Observational
In congenital cardiac intensive care, low cardiac output syndrome (LCOS) after surgery is defined by a decrease in cardiac output due to cardiac dysfunction. This syndrome is responsible for postoperative mortality and morbidity, as well as prolonged hospitalization.
carbon dioxide (CO2)-derived parameters are increasingly used to identify low cardiac output status by the venous-to-arterial carbon dioxide difference (PCO2 gap), or anaerobic metabolism by the venous-to-arterial carbon dioxide difference to arterial-to-venous oxygen content difference (Pv-aCO2/Ca-vO2) ratio, particularly in septic shock in adults, with or without hypoxemia. The thresholds proposed as pathological values were a PCO2 gap ≥ 6 mmHg and a Pv-aCO2/Ca-vO2 ratio ≥ 1.4 mmHg/ml. However, these markers have not been studied in depth in patients who have undergone cardiac surgery. In adults, studies have focused on the predictive value of the PCO2 gap and Pv-aCO2/Ca-vO2 on postoperative complications. In the pediatric population following cardiac surgery, only retrospective studies exist, with conflicting results on the correlation between the PCO2 gap and cardiac output, and the PCO2 gap and duration of mechanical ventilation.
This study aims to compare the performance of CO2-derived parameters in predicting LCOS and anaerobic metabolism in children after cardiac surgery with cardiopulmonary bypass.
99 studies on the registry are indexed under Cardiac Output, Low; 15 are open to participants now.
This study's planned enrollment of 306 is above the median of 66 across 48 observational studies indexed under Cardiac Output, Low.
Browse Cardiac Output, Low studies →University Hospital, Lille is the lead sponsor of 631 studies on the registry; 142 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Children after cardiac surgery with cardiopulmonary bypass (CPB)
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Exclusion Criteria:
Receiver Operating Characteristic (ROC) curve of PCO2 gap
Time frame: 2 hours
ROC curve of Pv-aCO2/Ca-vO2
Time frame: 2 hours
Pv-aCO2/Ca-vO2 and post-operatory complications
Time frame: 48 hours
Plan to share: No
No publications or documents are linked to this record.
Started Jun 2026 (actual). Primary completion is estimated for Jun 2029, 36 months after the start.
Of 22 observational studies under Cardiac Output, Low, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 34. This study's planned 36 months is above that.
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