Aphasia, Primary Progressive clinical trials
The registry lists 77 studies for Aphasia, Primary Progressive across more than 10 countries. 29 are recruiting or about to start. 49 of them are mainly about Aphasia, Primary Progressive (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-26. Counting its narrower condition Primary Progressive Nonfluent Aphasia too: 86 studies, 31 open.
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Who runs them
University of Chicago (8) · Johns Hopkins University (7) · University of Pennsylvania (5) · Mayo Clinic (4) · University of Texas at Austin (4) · Hospital San Carlos, Madrid (3) · IRCCS Centro San Giovanni di Dio Fatebenefratelli (2) · Peking Union Medical College Hospital (2)
What is being tested here
Drugs under test in Aphasia, Primary Progressive studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Flortaucipir | 1 | 0 | 2 |
| Propranolol | 1 | 0 | 1 |
| VX-745 | 0 | 0 | 1 |
| Rotigotine | 0 | 0 | 1 |
| Pittsburgh compound B | 0 | 0 | 1 |
| Nabilone | 0 | 0 | 1 |
| AADvac1 | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling · University Health Network, Toronto
- Dec 2026Propranolol in Primary Progressive Aphasia · University of Missouri-Columbia
- Dec 2026Enhancing Language Function in Primary Progressive Aphasia · University of Arizona
- Dec 2026Memory and Social Interactions · University Hospital, Caen
- Feb 2027Tracking and Predicting How Brain Damage Spreads in Neurodegenerative Diseases · IRCCS San Raffaele
- Feb 2027Speech and Language Interventions for Italian People With PPA · Istituti Clinici Scientifici Maugeri SpA
- Mar 2027Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia · University Hospital, Toulouse
- Apr 2027Language in Primary Progressive Aphasia · Northwestern University
- Apr 2027A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) · AviadoBio Ltd
- Apr 2027Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain Stimulation · The University of Texas at Dallas
Who these studies take
Of the 25 Aphasia, Primary Progressive studies recruiting now, 14 (56%) set no upper age limit and 1 (4%) stop at 75 or younger. 1 (4%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 10 (40%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (4%) | 1 (4%) |
| 18 | 12 (48%) | 12 (48%) |
| 30 | 15 (60%) | 15 (60%) |
| 40 | 20 (80%) | 20 (80%) |
| 50 | 25 (100%) | 25 (100%) |
| 65 | 25 (100%) | 25 (100%) |
| 75 | 25 (100%) | 25 (100%) |
| 85 | 21 (84%) | 21 (84%) |
Across all 77 studies, recruiting or not: 4% stop at 75 or younger and 0% at 65; 10% take children; 0% are for women only and 0% for men only; 32% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Aphasia, Primary Progressive studies take
Of 38 interventional studies with no phase under Aphasia, Primary Progressive, half reached primary completion within 41 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 41 mo26–59 · 38 studies | — | 41 mo26–59 · 38 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Results posted2
- Home-based tDCS in Frontotemporal Dementia or Alzheimer's DiseaseOct 21, 2026NCT05978804
- Treating Primary Progressive Aphasia (PPA) Using High-definition tDCSOct 19, 2026NCT04046991
Studies
Recruiting first, then most recently updated. Showing 50 of 77. Browse all 77 → or search them.
- Speech and Language Interventions for Italian People With PPARecruitingNCT067399671 country
- Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPARecruitingNCT03887481Not applicable1 country
- Remotely-supervised Neuromodulation in PPARecruitingNCT07260253Not applicable1 country
- Biofluid Research on Age-Related or Inherited NeurodegenerationRecruitingNCT077987001 country
- A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)RecruitingNCT06064890Phase 1/29 countries
- Semantic Rehabilitation for Patients With Primary Progressive Semantic AphasiaRecruitingNCT04957537Not applicable1 country
- Propranolol in Primary Progressive AphasiaRecruitingNCT06066710Early Phase 11 country
- Stimulating the Aging Brain Using Brain and Sensory StimulationRecruitingNCT07650188Not applicable1 country
- Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive AphasiaRecruitingNCT05741853Not applicable2 countries
- Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive AphasiaRecruitingNCT06511752Early Phase 11 country
- Communication Bridge 3 StudyRecruitingNCT06191198Phase 21 country
- Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive AphasiaEnrolling by invitationNCT06921265Not applicable1 country
- Tracking and Predicting How Brain Damage Spreads in Neurodegenerative DiseasesEnrolling by invitationNCT07567664Not applicable1 country
- Transcranial Direct Current Stimulation in the Treatment of Primary Progressive AphasiaRecruitingNCT05386394Phase 22 countries
- The Neurobiology of Two Distinct Types of Progressive Apraxia of SpeechRecruitingNCT033130111 country
- Long Term Effect of Brain Stimulation in PPARecruitingNCT07158216Not applicable1 country
- Intervention for Communication Quality of Life in Primary Progressive AphasiaRecruitingNCT07219680Not applicable1 country
- Language in Primary Progressive AphasiaRecruitingNCT005370041 country
- UPenn Observational Research Repository on Neurodegenerative DiseaseRecruitingNCT047153991 country
- Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative ModelingRecruitingNCT065297441 country
- Longitudinal Multi-Modality Imaging in Progressive Apraxia of SpeechRecruitingNCT01818661Phase 41 country
- STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care PartnersRecruitingNCT06613204Not applicable1 country
- Speech-Language Treatment With Remotely Supervised Transcranial Direct Current Stimulation in Primary Progressive AphasiaEnrolling by invitationNCT05901233Not applicable1 country
- Primary Progressive Aphasia Multicomponent Language Treatment StudyEnrolling by invitationNCT06649084Not applicable1 country
- Enhancing Language Function in AphasiaRecruitingNCT05443633Not applicable1 country
- Enhancing Language Function in Primary Progressive AphasiaRecruitingNCT04920318Not applicable1 country
- Effects of Transcranial Direct Current Stimulation (tDCS) on Inhibition and Brain Function in Primary Progressive AphasiaRecruitingNCT06473714Not applicable1 country
- Memory and Social InteractionsRecruitingNCT058000281 country
- A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID:3430931RecruitingNCT05730023Not applicable1 country
- Home-based tDCS in Frontotemporal Dementia or Alzheimer's DiseaseTerminatedNCT05978804Not applicable1 country
- Treating Primary Progressive Aphasia (PPA) Using High-definition tDCSCompletedNCT04046991Phase 21 country
- Nabilone for Agitation in Frontotemporal DementiaTerminatedNCT05742698Phase 21 country
- Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered SpeechCompletedNCT05437159Not applicable1 country
- Clinical Study of Neflamapimod in Patients With Primary Progressive AphasiaActive, not recruitingNCT07033481Phase 22 countries
- Treating Primary Progressive Aphasia and Apraxia of Speech Using Non-invasive Brain StimulationActive, not recruitingNCT05368350Not applicable1 country
- TMS for the Treatment of Primary Progressive AphasiaCompletedNCT04188067Not applicable1 country
- Circuitry Assessment and Reinforcement Training Effects on RecoveryTerminatedNCT04290988Not applicable1 country
- Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal DementiaCompletedNCT02736695Phase 11 country
- Treatment for Speech and Language in Primary Progressive AphasiaActive, not recruitingNCT04881617Not applicable1 country
- Treating Primary Progressive Aphasia (PPA) Using tDCSCompletedNCT04566731Not applicable1 country
- Neuroinflammation in FTLDActive, not recruitingNCT068708381 country
- Communication Bridge Pilot StudyActive, not recruitingNCT06211374Not applicable1 country
- Transmagnetic Stimulation Pilot in Primary Progressive AphasiaCompletedNCT05860647Not applicable1 country
- Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural NetworksCompletedNCT031533711 country
- Effects of tDCS on Apraxia of Speech in Non-Fluent Primary Progressive AphasiaWithdrawnNCT04486586Not applicable1 country
- Tau PET Imaging in Atypical DementiasCompletedNCT03283449Phase 11 country
- Predict to Prevent PGRN DiseaseWithdrawnNCT06711510Not applicable
- Home-Based Exercise in Primary Progressive Aphasia (HEPPA)CompletedNCT06181500Not applicable1 country
- tDCS Intervention in Primary Progressive AphasiaCompletedNCT02606422Not applicable1 country
- Long-term Effect of TMS in Primary Progressive AphasiaCompletedNCT05842473Not applicable1 country