An observational study in Primary Progressive Aphasia, sponsored by Northwestern University. Recruiting at 1 site in United States. Per ClinicalTrials.gov, last updated 2026-02-27.
Sponsored by Northwestern University · Observational
The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.
The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.
During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), advanced imaging (MRI and PET), cognitive experiments, and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.
For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.
77 studies on the registry are indexed under Aphasia, Primary Progressive; 29 are open to participants now.
This study's planned enrollment of 500 is above the median of 166 across 14 observational studies indexed under Aphasia, Primary Progressive.
Browse Aphasia, Primary Progressive studies →Northwestern University is the lead sponsor of 1,423 studies on the registry; 198 are open to participants now.
Of its 105 completed or terminated interventional studies of FDA-regulated products, 78 (74%) have results posted.
Counted across the registry records on this site, refreshed daily.
Participants with PPA will be recruited from the Northwestern University Alzheimer's Disease Center Core registry, the Northwestern University Neurobehavior and Memory Clinic, and from those who contact the center that are interested in PPA research.
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Exclusion Criteria:
Individuals with primary progressive aphasia
Individuals with no diagnosis of any type of dementia
Neuropsychological variables
Time frame: Immediately after testing and at two years post-testing
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Aphasia, Primary Progressive →