An interventional study of Multicomponent Lexical Retrieval Cascade Training and Multicomponent Video Implemented Script Training in Aphasia in Primary Progressive Aphasia(PPA), Semantic Dementia and Logopenic Progressive Aphasia (LPA), sponsored by Maya Henry. Recruiting at 1 site in United States. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2026-04-21.
Sponsored by Maya Henry · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish.
The main questions the study aims to answer are:
Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life.
Participants will:
20 studies on the registry are indexed under Primary Progressive Nonfluent Aphasia; 8 are open to participants now.
This study's planned enrollment of 30 is close to the median of 33 across 15 interventional studies indexed under Primary Progressive Nonfluent Aphasia.
Browse Primary Progressive Nonfluent Aphasia studies →Maya Henry is the lead sponsor of 2 studies on the registry; 2 are open to participants now.
Compared within Primary Progressive Nonfluent Aphasia, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Aphasia, Primary Progressive. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Inclusion Criteria for Persons with PPA:
Inclusion criteria for Care Partners:
The participant and/or study partner must have basic experience using a computer.
Exclusion criteria for persons with PPA:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Individuals in the waitlist-control group will undergo initial assessment followed by a waiting interval of 12 (Multi-VISTA) or 13 (Multi-LRCT) weeks. Following the waiting period, they will again complete baseline assessments prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment).
Behavioral: Multicomponent Lexical Retrieval Cascade Training · Behavioral: Multicomponent Video Implemented Script Training in Aphasia
Individuals in the immediate treatment group will undergo initial assessment followed immediately by the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment).
Behavioral: Multicomponent Lexical Retrieval Cascade Training · Behavioral: Multicomponent Video Implemented Script Training in Aphasia
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant targets in multiple communication modalities. Biweekly (45-90 minute) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Also known as: Multi-LRCT
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (45-90 minute) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
Also known as: Multi-VISTA
Change in spoken naming of trained/untrained items
Percent correctly named trained/untrained pictures
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change in script production accuracy
Percent correct intelligible, scripted words for trained/untrained scripts
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change in barriers and facilitators in dyad conversation
Number of conversation barriers and facilitators observed in conversation
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Communication Modality Inventory
A likert-type survey characterizing frequency and type of communication modalities used in conversation, administered to both the person with PPA and their conversation partner.
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change on Quick Aphasia Battery
A standardized aphasia assessment.
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change on Aphasia Impact Questionnaire
A psychosocial questionnaire for individuals with aphasia. Scores range from 0-84, with higher scores indicating greater impact of aphasia.
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Acceptability and Perception of Change Survey
A survey characterizing acceptability of and perceived response to treatment.
Time frame: post-treatment (approximately 12-13 weeks after treatment onset)
Change on Adult Carers Quality of Life Questionnaire
A measure evaluating quality of life for caregivers. Scores range from 0-100, with higher scores indicating greater quality of life.
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Change on Brief - Coping Orientation to Problems Experienced Inventory (Brief-COPE)
A survey characterizing care partner use of coping strategies.
Time frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment
Plan to share: Undecided — Because of the possibility of deductive disclosure of subjects with unusual characteristics and the sensitive nature of the protected health information obtained in this trial, we will make decisions about data sharing on request, with IRB oversight.
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Primary Progressive Nonfluent Aphasia →
Maya Henry