Primary Progressive Nonfluent Aphasia clinical trials

The registry lists 20 studies for Primary Progressive Nonfluent Aphasia across 4 countries. 8 are recruiting or about to start. 10 of them are mainly about Primary Progressive Nonfluent Aphasia (how this is decided). Per ClinicalTrials.gov, last updated 2026-05-05.

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Status

Completed: 7
Recruiting: 7
Terminated: 2
Status unknown: 1
Active, not recruiting: 1
Enrolling by invitation: 1

Phase

Phase 1: 4
Phase 4: 1
Early Phase 1: 1
Phase 2: 1

Where

United States: 13
Canada: 6
Germany: 1
Sweden: 1

Who runs them

University of California, San Francisco (4) · Mayo Clinic (3) · University of British Columbia (2) · University of Texas at Austin (2) · Axon Neuroscience SE (1) · Johns Hopkins University (1) · Massachusetts General Hospital (1) · Northwestern University (1)

What is being tested here

Drugs under test in Primary Progressive Nonfluent Aphasia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	All
Flortaucipir	1	1
Davunetide	0	1
Pittsburgh compound B	0	1
Gosuranemab	0	1
AADvac1	0	1

Coming up

0phase 3 studies under way

4studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 4

Dec 2026Diagnosing Frontotemporal Lobar Degeneration · University Health Network, Toronto
Apr 2027Language in Primary Progressive Aphasia · Northwestern University
Jul 2027The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech · Mayo Clinic
Aug 2027Intervention for Communication Quality of Life in Primary Progressive Aphasia · Maya Henry

Who these studies take

Of the 7 Primary Progressive Nonfluent Aphasia studies recruiting now, 4 (57%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (14%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (43%) take healthy volunteers.

Recruiting studies that take each age, of 7
Age	Women	Men
10	1 (14%)	1 (14%)
18	4 (57%)	4 (57%)
30	5 (71%)	5 (71%)
40	6 (86%)	6 (86%)
50	7 (100%)	7 (100%)
65	7 (100%)	7 (100%)
75	7 (100%)	7 (100%)
85	7 (100%)	7 (100%)

Across all 20 studies, recruiting or not: 0% stop at 75 or younger and 0% at 65; 20% take children; 0% are for women only and 0% for men only; 30% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 20 of 20. search them.