An interventional study of Multicomponent Lexical Retrieval Training (Multi-LRT) and Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA) in Primary Progressive Aphasia, Semantic Dementia and Semantic Memory Disorder, sponsored by University of Texas at Austin. Enrolling by invitation at 1 site in United States. Per ClinicalTrials.gov, last updated 2025-10-08.
Sponsored by University of Texas at Austin · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to learn if a speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language. The study will also document how acceptable and helpful the program is for both patients and their care partners.
The main questions the study aims to answer are:
Researchers will test the program in a small group of participants to see how people respond. The program includes both speech-language therapy and training for care partners.
Participants will:
20 studies on the registry are indexed under Primary Progressive Nonfluent Aphasia; 8 are open to participants now.
This study's planned enrollment of 21 is below the median of 33 across 15 interventional studies indexed under Primary Progressive Nonfluent Aphasia.
Browse Primary Progressive Nonfluent Aphasia studies →University of Texas at Austin is the lead sponsor of 328 studies on the registry; 79 are open to participants now.
Of its 10 completed or terminated interventional studies of FDA-regulated products, 5 (50%) have results posted.
Compared within Primary Progressive Nonfluent Aphasia, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Aphasia, Primary Progressive. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Behavioral: Multicomponent Lexical Retrieval Training (Multi-LRT)
Behavioral: Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)
Behavioral: Multicomponent Communication Partner Training (Multi-CPT)
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant target in multiple communication modalities. Treatment focuses on the use of strategies which capitalize on residual linguistic ability and autobiographical memory to support word retrieval. The participant completes two one-hour-long sessions per week plus daily homework. The participant also meets 4 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing personally relevant scripts of 3-5 sentences in length. Length and complexity of scripts are individually tailored. The participant completes 30 minutes per day of home practice, during which they speak in unison with a video/audio model of a healthy speaker clearly articulating the scripts. Biweekly (one hour each) sessions with a clinician are held which target clear and accurate script production, script memorization, and conversational usage of the script and multimodal communication. The participant also meets 6 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
In person or via teletherapy: A multi-component treatment incorporating elements of compensatory and care-partner focused interventions. Biweekly (one hour each) sessions with a clinician are held which target use of communication strategies including multimodal communication for the participant and study partner (e.g., spouse). The participant also completes regular assignments meant to increase generalization of communication strategies and progress on personal goals.
Change in script production accuracy
Percent correct intelligible, scripted words for trained/untrained scripts
Time frame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Change in spoken naming of trained/untrained items
Percent correctly named trained/untrained pictures
Time frame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Information communicated in any modality for trained/untrained stimuli
Percent of major content units (key words) communicated via speech or nonspeech modalities (e.g., writing, drawing, gesture) for trained/untrained scripts (Multi-VISTA) or words (Multi-LRT) during structured probes and in conversation
Time frame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Goal Attainment Score
The Goal Attainment Score is self-reported progress on personalized goals based on a five point scale.
Time frame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Change on Quick Aphasia Battery
change on standardized aphasia assessment
Time frame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Change on Aphasia Impact Questionnaire
change on psychosocial questionnaire for individuals with aphasia
Time frame: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Post-treatment Communication Survey
survey characterizing perceived response to treatment
Time frame: post-treatment (approximately 6-12 weeks after treatment onset)
Plan to share: No
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Primary Progressive Nonfluent Aphasia →
University of Texas at Austin →