An interventional study of Lexical Retrieval Cascade Treatment and Remotely Supervised Transcranial Direct Current Stimulation- Active in Primary Progressive Aphasia(PPA), Progressive Aphasia and Progressive Aphasia in Alzheimer's Disease, sponsored by Maya Henry. Recruiting at 2 sites in United States. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2026-09-04.
Sponsored by Maya Henry · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to learn whether home-based brain stimulation combined with virtual speech-language therapy can improve communication abilities in adults with logopenic variant primary progressive aphasia (lvPPA), a language disorder most often caused by Alzheimer's disease.
The main questions the study aims to answer are:
Researchers will compare participants who receive active tDCS plus virtual speech-language therapy to participants who receive sham (placebo) tDCS plus virtual speech-language therapy to see if active brain stimulation enhances communication outcomes.
Participants will:
77 studies on the registry are indexed under Aphasia, Primary Progressive; 29 are open to participants now.
This study's planned enrollment of 80 is above the median of 30 across 60 interventional studies indexed under Aphasia, Primary Progressive.
Browse Aphasia, Primary Progressive studies →Maya Henry is the lead sponsor of 2 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive virtual language therapy in conjunction with active remotely-supervised transcranial direct current stimulation.
Behavioral: Lexical Retrieval Cascade Treatment · Device: Remotely Supervised Transcranial Direct Current Stimulation- Active
Participants will receive virtual language therapy in conjunction with sham remotely-supervised transcranial direct current stimulation.
Behavioral: Lexical Retrieval Cascade Treatment · Device: Remotely Supervised Transcranial Direct Current Stimulation - Sham
Participants work on producing spoken and written names of personally-relevant target items. Treatment focuses on the use of strategies that capitalize on spared cognitive-linguistic abilities to support word retrieval. The participant completes two (one hour each) teletherapy sessions per week with a clinician plus 30 minutes of additional independent, computer-based practice exercises 3 times per week.
Also known as: LRCT
tDCS is a type of non-invasive brain stimulation. 2.0 milliamp (mA) of current will be delivered via electrodes in saline-soaked sponges placed on the left and right sides of the head. The stimulation will last 20 minutes and will occur 5 times weekly, in the participant's home setting, while the participant engages in computer-delivered speech-language training. Sessions are monitored by study personnel.
tDCS is a type of non-invasive brain stimulation. 2.0 milliamp (mA) of current will be delivered via electrodes in saline-soaked sponges placed on the left and right sides of the head. In sham stimulation, current will be delivered for a brief period of time and then turned off. Sham stimulation will last 20 minutes and will occur 5 times weekly, in the participant's home setting, while the participant engages in computer-delivered speech-language training. Sessions are monitored by study personnel.
Change in spoken naming
Change in percent correctly named trained/untrained pictures
Time frame: change from pre-treatment to one month and three months after onset of treatment in each phase (stimulation and sham)
Change on Communication Confidence Rating Scale for Aphasia
Change on self-rating scale evaluating communication confidence in different settings for persons with aphasia. A higher score indicates greater confidence, with minimum and maximum values of 0 and 100.
Time frame: change from pre-treatment to one month and three months after onset of treatment in each phase (stimulation and sham)
Change on Aphasia Impact Questionnaire
Change on patient reported outcome measure for persons with aphasia; characterizes activities, participation and emotional state/wellbeing using a 5-point pictorial rating scale. A higher score indicates greater impact of aphasia, with minimum and maximum values of 0 and 84.
Time frame: change from pre-treatment to one month and three months after onset of treatment in each phase (stimulation and sham)
Theoretical Framework of Acceptability Questionnaire
The Theoretical Framework of Acceptability questionnaire is a measure developed for healthcare interventions to identify characteristics of interventions that may be improved or that were well-received.
Time frame: one month after onset of treatment
Acceptability and Perception of Change Survey
The Acceptability and Perception of Change Survey characterizes perceived response to treatment.
Time frame: one month after onset of treatment
Plan to share: Yes — De-identified individual participant data, including behavioral and MRI/fMRI data from 80 individuals with lvPPA and limited data from study partners, will be shared via the ICPSR repository. Data will be available at publication or within 9 months of database lock, and accessible for at least 10 years. Publicly shared datasets will exclude identifiable information, audio/video files, and non-skull-stripped imaging. Additional data may be shared via IRB-approved data-sharing agreements.
Time frame: De-identified clinical trial data (participant level and summary level data, raw and processed) will be made available at the time of publication of the primary results or within 9 months of database lock, whichever comes first. We will also include relevant datasets as supplementary material accompanying articles submitted to PubMed Central. Data will be publicly available for 10 years following the end of the award and by request thereafter.
Access criteria: De-identified data will be accessible to researchers and the broader scientific community. Publicly available datasets will be hosted on the ICPSR repository and accessible via DOI. Additional data (e.g., voice samples) may be accessed through an IRB-approved data-sharing agreement, which will require users to commit to secure data handling and non-identification of participants.
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Maya Henry