Ankle Fractures clinical trials
The registry lists 202 studies for Ankle Fractures across more than 10 countries. 44 are recruiting or about to start. 170 of them are mainly about Ankle Fractures (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Ostfold Hospital Trust (5) · Oslo University Hospital (5) · Sohag University (4) · Ludwig-Maximilians - University of Munich (4) · Assiut University (4) · Inion Oy (3) · NYU Langone Health (3) · Ottawa Hospital Research Institute (3)
What is being tested here
Drugs under test in Ankle Fractures studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Nitroglycerin | 1 | 0 | 1 |
| Buprenorphine | 1 | 0 | 1 |
| Bupivacaine | 0 | 2 | 4 |
| Liposomal Bupivacaine | 0 | 1 | 3 |
| Epinephrine | 0 | 0 | 2 |
| Ropivacaine | 0 | 1 | 2 |
| Oxygen | 0 | 1 | 1 |
| Oxycodone | 0 | 0 | 1 |
| Aspirin | 0 | 0 | 1 |
| Vancomycin | 0 | 0 | 1 |
Drug classes tested here Opioids 1 open · Local anesthetics 5 · NSAIDs 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Double Compression Screw Fixation for Symptomatic Non-union of Lateral Malleolar Ankle Fractures · Sohag University
- Nov 2026Plate Versus Intramedullary Screw for Lateral Malleolus Fracture in Ankle Fracture Type A&B · Sohag University
- Dec 2026FRAME Study (Frailty-Related Ankle Fracture Management and Evaluation) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Dec 2026Simplified Post Op Rehabilitation for Ankle and Pilon Fractures · University of Virginia
- Dec 2026Neuromuscular Electrical Stimulation in Foot and Ankle Surgery · NYU Langone Health
- Dec 2026Go Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS® · AO Innovation Translation Center
- Dec 2026Fibulink Syndesmosis Repair System With Early Full-Weight Bearing · Maimonides Medical Center
- Dec 2026Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries · University of California, San Diego
- Dec 2026The Benefit of Repairing the Deltoid Ligament in Unstable Ankle Fractures · Ostfold Hospital Trust
- Feb 2027Single-Window Versus Two-Window Posterolateral Approach for Malleolar Fractures · muhammed kılıç
Who these studies take
Of the 31 Ankle Fractures studies recruiting now, 14 (45%) set no upper age limit and 12 (39%) stop at 75 or younger. 4 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (3%) | 1 (3%) |
| 18 | 27 (87%) | 27 (87%) |
| 30 | 28 (90%) | 28 (90%) |
| 40 | 29 (94%) | 29 (94%) |
| 50 | 29 (94%) | 29 (94%) |
| 65 | 28 (90%) | 28 (90%) |
| 75 | 20 (65%) | 20 (65%) |
| 85 | 18 (58%) | 18 (58%) |
Across all 202 studies, recruiting or not: 41% stop at 75 or younger and 28% at 65; 10% take children; 0% are for women only and 0% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Ankle Fractures studies take
Of 72 interventional studies with no phase under Ankle Fractures, half reached primary completion within 45 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 45 mo23–61 · 72 studies | — | 44 mo23–61 · 69 studies |
| Observational | 32 mo12–… · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
- Hardware Removal After ORIF of Ankle FracturesOct 23, 2026NCT05798741
- Physical Recovery During Bracing After Ankle Fracture (Re-BAF)Oct 16, 2026NCT07521696
Newly registered3
- Electronic Decision Support for Ankle Injury X-Ray AssessmentNov 3, 2026NCT07912476
- Virtual Reality-Integrated Rehabilitation Versus Conventional Balance Therapy Following Ankle FractureOct 30, 2026NCT07906002
- Use of Bioresorbable Magnesium Set Screws in Syndesmotic Injuries: a Pilot StudyOct 28, 2026NCT07901205
Studies
Recruiting first, then most recently updated. Showing 50 of 202. Browse all 202 → or search them.
- Biodegradable Magnesium Screws for Unstable Ankle Fracture SurgeryNot yet recruitingNCT07693933Not applicable1 country
- Use of Bioresorbable Magnesium Set Screws in Syndesmotic Injuries: a Pilot StudyRecruitingNCT079012051 country
- Hardware Removal After ORIF of Ankle FracturesRecruitingNCT05798741Not applicable1 country
- Physical Recovery During Bracing After Ankle Fracture (Re-BAF)RecruitingNCT07521696Not applicable1 country
- Randomized Controlled Trial for Ankle Fracture Pain ControlRecruitingNCT03696199Phase 41 country
- Dynamic Fixation for Complex Ankle Fractures With Syndesmotic Diastasis.Not yet recruitingNCT07831265Not applicable
- A Study to Compare Two Different Managements After Ankle Surgery: Immediate and Delayed Weight-bearing.RecruitingNCT04429217Not applicable1 country
- Early Ambulation Safely in Unstable Ankle Fractures (EASY-Ankle)Not yet recruitingNCT07811804Not applicable1 country
- Early Virtual Ankle Rehabilitation (EVAR): AcceptabilityNot yet recruitingNCT07751107Not applicable1 country
- Immediate Vs. Delayed Weight Bearing Postoperative Protocol in Diabetic Ankle FracturesRecruitingNCT03966027Not applicable1 country
- Simplified Post Op Rehabilitation for Ankle and Pilon FracturesRecruitingNCT05280639Not applicable1 country
- Performance and Safety Follow-up of Bioabsorbable Headless Inion CompressOnTM Screws in the Fixation of Bone Fractures in Ankle, Knee and Elbow of Pediatric and Adolescent PatientsRecruitingNCT07473947Not applicable1 country
- Bracing After Ankle FractureRecruitingNCT07163091Not applicable2 countries
- Double Compression Screw Fixation for Symptomatic Non-union of Lateral Malleolar Ankle FracturesRecruitingNCT07539922Not applicable1 country
- Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture SurgeryRecruitingNCT06949826Phase 41 country
- Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.Not yet recruitingNCT07004764Phase 11 country
- Fibulink Syndesmosis Repair System With Early Full-Weight BearingRecruitingNCT06085586Not applicable1 country
- Performance and Safety Evaluation of Inion CompressOn Screw in Foot and Ankle Surgeries. PMCF InvestigationRecruitingNCT05555459Not applicable1 country
- Plate Versus Intramedullary Screw for Lateral Malleolus Fracture in Ankle Fracture Type A&BNot yet recruitingNCT07447336Not applicable1 country
- Neuromuscular Electrical Stimulation in Foot and Ankle SurgeryRecruitingNCT06370325Not applicable1 country
- Ankle Fracture Tourniquet UtilizationEnrolling by invitationNCT06863688Not applicable1 country
- Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis InjuriesRecruitingNCT05729542Not applicable1 country
- Conjoint Analysis of Patient Preferences in Joint InterventionsEnrolling by invitationNCT02664337Not applicable1 country
- FRAME Study (Frailty-Related Ankle Fracture Management and Evaluation)RecruitingNCT051313211 country
- Efficacy and Clinical Feasibility of the Ankle Muscle Power (AMP) Program for Return to Duty After an Ankle FractureRecruitingNCT07173088Not applicable1 country
- The Benefit of Repairing the Deltoid Ligament in Unstable Ankle FracturesRecruitingNCT06568276Not applicable1 country
- The Efficacy and Safety of Venostan in Promoting Postoperative Swelling Reduction in Patients With Ankle FracturesRecruitingNCT06872034Not applicable1 country
- Correlation Between Intraoperative Tourniquet Use and Limb pH, Functional Measures and Patient-reported Outcomes After Ankle Fracture SurgeryRecruitingNCT05445960Not applicable1 country
- Compression Therapy for Swelling Management Following Ankle InjuryNot yet recruitingNCT06772649Phase 41 country
- Tibio-talo-calcaneal Fusion by Hindfoot Nail Versus Open Reduction and Internal Fixation in Treatment of Complex Fractures Distal Tibial and Fragility Ankle Fractures in ElderlyRecruitingNCT06709365Not applicable1 country
- Opioid-Free Pain Treatment in Trauma PatientsRecruitingNCT06078371Not applicable1 country
- Osteosynthesis of High-Risk Ankle Fractures Using Locked Fibula Nails: What Results for Which Patients?RecruitingNCT065182651 country
- Randomized Controlled Trial Comparing Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis InjuriesRecruitingNCT05626036Not applicable1 country
- Prospective Follow-up of the Results of Nail Arthrodesis of the AnkleNot yet recruitingNCT06338566
- Detecting and Assessing Leg and Foot Stress Fractures Using Photon Counting CTRecruitingNCT060247981 country
- Sciatic Nerve Block for Ankle and Leg Fracture Manipulation in the Emergency DepartmentNot yet recruitingNCT06329752Not applicable1 country
- Swedish Multicenter Trial of Outpatient Prevention of Leg ClotsRecruitingNCT03259204Not applicable1 country
- Weber B Ankle Fractures With Associated Posterior Malleolus FractureRecruitingNCT05413707Not applicable1 country
- Functional Outcomes Following Ankle Fracture Fixation With or Without Ankle ArthroscopyNot yet recruitingNCT06086223Not applicable
- Improving Patient Understanding in Preoperative Informed Consent Process of Trauma Patients Using a Mixed Reality ViewerRecruitingNCT06062797Not applicable1 country
- Diagnostic Ultrasonography in PhysiotherapyRecruitingNCT059163001 country
- The Effect of Deltoid Ligament Repair in Patients With Weber B Ankle Fracture; Randomized Controlled Trial.Not yet recruitingNCT05793606Not applicable
- Nerve Block for Pain Control After Fracture SurgeryRecruitingNCT05391464Not applicable1 country
- Comparison of the Results of Complex Ankle Fractures Treated With and Without Ankle ArthroscopyRecruitingNCT02449096Not applicable1 country
- Weight-bearing Radiographs to Evaluate Stability in Ankles With Isolated Weber Type B Fractures.Active, not recruitingNCT03831009Not applicable1 country
- Use of Weightbearing Radiographs to Determine Treatment of bi- and Trimalleolar Ankle FracturesActive, not recruitingNCT05765929Not applicable1 country
- Electronic Decision Support for Ankle Injury X-Ray AssessmentCompletedNCT07912476Not applicable1 country
- Virtual Reality-Integrated Rehabilitation Versus Conventional Balance Therapy Following Ankle FractureCompletedNCT07906002Not applicable1 country
- Telerehabilitation in Patients With Ankle FractureCompletedNCT06811090Not applicable1 country
- Turkish Version of the Ankle Fracture Outcome of Rehabilitation Measure (A-FORM-TR): A Multi-Centre Validation StudyActive, not recruitingNCT076200152 countries