Ankle Injuries clinical trials
The registry lists 350 studies for Ankle Injuries across more than 10 countries. 74 are recruiting or about to start. 284 of them are mainly about Ankle Injuries (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06. Counting its narrower condition Ankle Fractures too: 526 studies, 109 open.
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Status
Who runs them
Riphah International University (10) · Cairo University (7) · University of Virginia (6) · Bahçeşehir University (5) · Hacettepe University (5) · Novartis (5) · Peking University Third Hospital (5) · University of Lahore (4)
What is being tested here
Drugs under test in Ankle Injuries studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Methylprednisolone | 1 | 0 | 1 |
| Platelet rich plasma | 1 | 0 | 1 |
| Diclofenac | 0 | 3 | 5 |
| Bupivacaine | 0 | 0 | 3 |
| Diclofenac diethylamine | 0 | 2 | 3 |
| Ketoprofen | 0 | 1 | 3 |
| Acetaminophen | 0 | 0 | 2 |
| Traumeel S | 0 | 2 | 2 |
| Liposomal Bupivacaine | 0 | 0 | 1 |
| Dexamethasone | 0 | 0 | 1 |
Drug classes tested here Corticosteroids 1 open · NSAIDs 11 · Local anesthetics 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Comparison of the Effects of Hip and Ankle Focused Progressive Exercise Training on Lower Extremity Function in Athletes With Chronic Ankle Instability · Hacettepe University
- Nov 2026Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy · Second Affiliated Hospital, School of Medicine, Zhejiang University
- Dec 2026Ankle Instability Using Foot Intensive Rehabilitation · Matthew Hoch
- Dec 2026Arthroscopic Versus Open Brostrom for Ankle Instability · Federal University of São Paulo
- Dec 2026Effects Of Criteria Versus Time-Based Rehabilitation On Return To Play In Football Players · Riphah International University
- Dec 2026Semiconductor Embedded Socks for Ankle Sprains · University of Colorado, Denver
- Dec 2026Does Performing a Composite Test 3 Months Post-operatively Reduce the Risk of Failure to Return to Sport After Lateral Ankle Ligamentoplasty? · Clinique du Sport, Bordeaux Mérignac
- Dec 2026Fibulink Syndesmosis Repair System With Early Full-Weight Bearing · Maimonides Medical Center
- Dec 2026Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries · University of California, San Diego
- Dec 2026Mulligan Mobilization With Movement for Acute Lateral Ankle Sprains · Université Catholique de Louvain
Who these studies take
Of the 46 Ankle Injuries studies recruiting now, 11 (24%) set no upper age limit and 32 (70%) stop at 75 or younger. 10 (22%) take children under 18. 1 (2%) are for women only and 0 (0%) for men only; 8 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (7%) | 3 (7%) |
| 18 | 45 (98%) | 44 (96%) |
| 30 | 42 (91%) | 41 (89%) |
| 40 | 33 (72%) | 33 (72%) |
| 50 | 29 (63%) | 29 (63%) |
| 65 | 20 (43%) | 20 (43%) |
| 75 | 14 (30%) | 14 (30%) |
| 85 | 14 (30%) | 14 (30%) |
Across all 350 studies, recruiting or not: 67% stop at 75 or younger and 62% at 65; 24% take children; 1% are for women only and 7% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Ankle Injuries studies take
Of 141 interventional studies with no phase under Ankle Injuries, half reached primary completion within 9 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 9 mo4–31 · 141 studies | — | 9 mo4–30 · 138 studies |
| Observational | 11 mo5–45 · 38 studies | — | 11 mo5–45 · 34 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
Newly registered4
- Functional Recovery After a Recent Lateral Ankle Sprain With Early Initiation of Rehabilitation: Changes in the Ankle-GO Score and Its Association With Return to Sport and Recurrent Sprains.Nov 4, 2026NCT07917273
- Electronic Decision Support for Ankle Injury X-Ray AssessmentNov 3, 2026NCT07912476
- Use of Bioresorbable Magnesium Set Screws in Syndesmotic Injuries: a Pilot StudyOct 28, 2026NCT07901205
- Collagen Scaffold Bioaugmentation for ATFL Repair in Chronic Ankle InstabilityOct 16, 2026NCT07878312
Studies
Recruiting first, then most recently updated. Showing 50 of 350. Browse all 350 → or search them.
- Biodegradable Magnesium Screws for Unstable Ankle Fracture SurgeryNot yet recruitingNCT07693933Not applicable1 country
- Functional Recovery After a Recent Lateral Ankle Sprain With Early Initiation of Rehabilitation: Changes in the Ankle-GO Score and Its Association With Return to Sport and Recurrent Sprains.Not yet recruitingNCT07917273Not applicable1 country
- Enovis High Ankle Sprain Brace TestingRecruitingNCT06719609Not applicable1 country
- The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Amateur Athletes With Chronic Ankle InstabilityRecruitingNCT07760233Not applicable1 country
- Use of Bioresorbable Magnesium Set Screws in Syndesmotic Injuries: a Pilot StudyRecruitingNCT079012051 country
- Outpatient Floor Pedal Bike UtilizationNot yet recruitingNCT06586190Not applicable
- The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Chronic Ankle InstabilityRecruitingNCT07728526Not applicable1 country
- Collagen Scaffold Bioaugmentation for ATFL Repair in Chronic Ankle InstabilityNot yet recruitingNCT07878312Not applicable1 country
- Accuro XV Ultrasound Imaging System for BoneEnhance and Fracture Detection AlgorithmsRecruitingNCT07853768Not applicable1 country
- Comparison of the Effects of Hip and Ankle Focused Progressive Exercise Training on Lower Extremity Function in Athletes With Chronic Ankle InstabilityRecruitingNCT07319403Not applicable1 country
- Computed Tomography With Stress Maneuvers for Evaluation of Distal Tibiofibular Syndesmosis Instability (CTMETS)RecruitingNCT040955981 country
- Study of the AxisBoard Single-Leg Balance Board in Adults With Lateral Ankle SprainNot yet recruitingNCT07860125Not applicable
- Mulligan Mobilization With Movement for Acute Lateral Ankle SprainsRecruitingNCT07849374Not applicable1 country
- Effects Of Criteria Versus Time-Based Rehabilitation On Return To Play In Football PlayersRecruitingNCT07815340Not applicable1 country
- The Safety of Reusing Walking Boot Components for Patients Recovering From Acute Foot and Ankle InjuriesEnrolling by invitationNCT07287969Not applicable1 country
- Dynamic Neuromuscular Stability Exercises With and Without Rhythmic Auditory Stimulation in Lateral Ankle SprainRecruitingNCT07726810Not applicable1 country
- Auditory Biofeedback Gait Training Individuals With Chronic Ankle InstabilityRecruitingNCT06868316Not applicable1 country
- Ankle vs. Hip vs. Combined Strengthening in Chronic Ankle InstabilityRecruitingNCT07606534Not applicable1 country
- Comparison of MBR + Suture Tape and MBR for CLAI : A Prospective Cohort StudyRecruitingNCT068972931 country
- Pelvic Parameters in Males With and Without Ankle InstabilityNot yet recruitingNCT07594210
- Semiconductor Embedded Socks for Ankle SprainsRecruitingNCT07025733Not applicable1 country
- Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal DisordersNot yet recruitingNCT07508163
- Does Performing a Composite Test 3 Months Post-operatively Reduce the Risk of Failure to Return to Sport After Lateral Ankle Ligamentoplasty?RecruitingNCT06395714Not applicable1 country
- Fibulink Syndesmosis Repair System With Early Full-Weight BearingRecruitingNCT06085586Not applicable1 country
- Is 6 Weeks Immobilization for a Chopart Injury Still State of the Art? Comparison Between Cast Immobilization Versus Functional TreatmentNot yet recruitingNCT07477327Not applicable
- Comparison of Anesthetic Techniques for Early Recovery After Ankle ArthroscopyNot yet recruitingNCT07460310Not applicable
- Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical PatientsRecruitingNCT06780202Phase 21 country
- Resurfacing of Foot and Distal Leg Soft Tissue Defects Using Reversed Pedicled Peroneal Artery Flaps Augmented by Superficial Sural ArteryNot yet recruitingNCT07453199Not applicable
- Neurophysiology of Ankle InstabilityEnrolling by invitationNCT06576687Not applicable1 country
- the Efficacy of Hyperbaric Oxygen on Acute Ankle SprainNot yet recruitingNCT07405281Not applicable
- BioBrace® in Arthroscopic Brostrom Lateral Ankle Ligament RepairRecruitingNCT07401095Not applicable1 country
- Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis InjuriesRecruitingNCT05729542Not applicable1 country
- Postoperative Complications of Ankle ArthroscopyRecruitingNCT07335133Not applicable1 country
- Comparison Interventions on Kinetic and Kinematic ParametersEnrolling by invitationNCT07326475Not applicable1 country
- French Ankle Ligament Surgery Cohort StudyRecruitingNCT071883631 country
- NMES With PNF for Ankle Sprain RehabilitationRecruitingNCT07190599Not applicable1 country
- Dance Mental Health AppRecruitingNCT07219095Not applicable1 country
- Surgical Management of Lateral Ankle Instability: Modified Broström-Gould Versus Arthroscopic Allograft Reconstruction of the Anterior Talofibular and Calcaneofibular Ligaments.RecruitingNCT07200271Not applicable1 country
- Validity and Reliability of Calf Raise Tests in Patients With Achilles Tendon Rupture and Lateral Ankle SprainNot yet recruitingNCT07197593Not applicable
- Fu's Subcutaneous Needling for Postacute Lateral Ankle Sprain and Prevention of Chronic Ankle InstabilityNot yet recruitingNCT07161427Not applicable
- Validation of a Portable Ankle ArthrometerNot yet recruitingNCT071638971 country
- Neurocognitive Exercises for Ankle InstabilityNot yet recruitingNCT06567847Not applicable1 country
- MOTOR TRAINING VERSUS MOTOR COGNITIVE TRAINING IN ATHLETES WITH CHRONIC ANKLE INSTABILITYNot yet recruitingNCT07078916Not applicable1 country
- A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle InstabilityRecruitingNCT04999904Not applicable1 country
- Blood Flow Restriction and Proprioception Training on Ankle Joint SensationsNot yet recruitingNCT07030634Not applicable
- Correlation Between Ultrasound Findings Vs Intraoperative Findings in Syndesmotic Injury in Pott's Fracture Weber b and cNot yet recruitingNCT06945939Not applicable
- The Applicability of the Cumberland Ankle Instability Tool in Basketball Athletes.Not yet recruitingNCT06927557
- Comparison of MBR + Suture Tape, MBR, and Anatomic Reconstruction for CLAI in GJL Cases: A Prospective Cohort StudyRecruitingNCT056984461 country
- The Clinical Outcomes of the Modified Broström vs Anatomic Reconstruction Operation in CLAI and GJLRecruitingNCT051969061 country
- Spinal and Supraspinal Control in Chronic Ankle InstabilityRecruitingNCT06898554Not applicable1 country