An interventional study of remote ischemic preconditioning in Heart Valve Surgery and Acute Kidney Injury, sponsored by Fujian Medical University Union Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-10-22.
Sponsored by Fujian Medical University Union Hospital · Not applicable, Interventional, and Prevention
Patients undergoing heart valve surgery require cardiopulmonary bypass, a procedure that can lead to a temporary reduction in blood flow to major organs and subsequent ischemia-reperfusion injury, thereby triggering postoperative complications such as acute kidney injury and delirium. Current treatments for these complications primarily involve pharmacological and non-pharmacological interventions. Pharmacological interventions are not routinely employed due to limited supporting evidence, while non-pharmacological interventions are labor-intensive and lack systemic protective effects; thus, there is an urgent need for a systemic, non-pharmacological intervention that is easy to implement. This study aims to investigate the organ-protective effects of remote ischemic preconditioning-administered at different time points-following heart valve surgery, with the goal of developing a safe, effective, and clinically scalable nursing intervention protocol. Through this research, the investigators hope to further reduce the incidence of postoperative complications and improve clinical outcomes and prognoses for patients undergoing heart valve surgery.
1,641 studies on the registry are indexed under Acute Kidney Injury; 380 are open to participants now.
This study's planned enrollment of 291 is above the median of 100 across 786 interventional studies indexed under Acute Kidney Injury.
Browse Acute Kidney Injury studies →Fujian Medical University Union Hospital is the lead sponsor of 104 studies on the registry; 76 are open to participants now.
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Exclusion Criteria:
Remote ischemic preconditioning intervention was performed 24±4 hours before surgery.
Device: remote ischemic preconditioning
Two remote ischemic preconditioning interventions were performed 24±4 hours before surgery and again after anesthesia induction until the start of surgery.
Device: remote ischemic preconditioning
Routine care, without any special intervention.
The patient lies in the supine position, exposes the upper limbs, uses a sphygmomanometer, and ties the cuff to the upper limbs with a tightness that can accommodate one finger. The distance between the lower edge of the cuff and the antecubital space is 2cm. First, measure the patient's basal blood pressure. If the systolic blood pressure is less than 180mmHg, proceed to the next step of RIPC. In the same way, tie the compression therapy device cuff to the patient's upper limb, quickly pressurize to the pressure value of "basal systolic blood pressure + 50mmHg", maintain it for 5 minutes, and then quickly decompress to 0mmHg and maintain it for 5 minutes. This is an upper limb ischemia-reperfusion cycle. The ischemia-reperfusion procedure was repeated three times in total. The maximum pressure value during the operation shall not exceed 200mmHg. If the patient's systolic blood pressure is higher than 180mmHg or the hemodynamics is unstable, the intervention will be stopped.
the incidence of postoperative acute kidney injury
Time frame: From the date of surgery until the date of first documented AKI, assessed up to 7 days postoperatively.
the incidence of postoperative delirium
Time frame: From the date of surgery until the date of first documented POD, assessed up to 7 days postoperatively.
mechanical ventilation duration
Time frame: From the end of surgery until successful extubation, assessed up to 90 days postoperatively.
Plan to share: No
No publications or documents are linked to this record.
Started Mar 2026 (actual). Primary completion is estimated for Dec 2026, 9 months after the start.
Of 239 non-industry interventional studies with no phase under Acute Kidney Injury, half reached primary completion within 27 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 44. This study's planned 9 months is below that.
Counting every sponsor, half of 255 studies reached it within 26 months; a quarter within 12 and three quarters within 44.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Fujian Medical University Union Hospital →