An observational study in Acute Kidney Injury and Postoperative Complications, sponsored by Ankara Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-30.
Sponsored by Ankara Training and Research Hospital · Observational
This retrospective observational study examines whether troponin levels measured before surgery are associated with acute kidney injury during the first 48 hours after surgery in patients admitted to intensive care after noncardiac surgery. Troponin is a protein measured in blood that can indicate heart muscle injury. Acute kidney injury is a sudden decline in kidney function.
Existing medical records from 224 patients who underwent emergency or elective surgery will be reviewed. Kidney injury will be assessed using changes in blood creatinine levels and the need for dialysis or other kidney replacement therapy. The study will also examine changes in troponin levels around surgery, length of stay, and survival during hospitalization. No additional tests or treatments are performed for this study.
This single-center retrospective cohort study uses routinely collected clinical records of patients admitted to intensive care after noncardiac surgery who have available preoperative troponin measurements and postoperative kidney function data. Both emergency and elective procedures are included, and patients with chronic kidney disease are retained.
The primary objective is to evaluate the association between preoperative troponin concentration and acute kidney injury identified within 48 hours after surgery. Acute kidney injury is assessed using the serum creatinine and renal replacement therapy components of the Kidney Disease: Improving Global Outcomes criteria. Urine output criteria are not used because reliable retrospective measurements are unavailable.
Preoperative troponin is evaluated as a continuous variable and according to the laboratory upper reference limit. The main adjusted analysis accounts for age, Charlson Comorbidity Index, baseline serum creatinine, and surgical urgency. A sensitivity analysis considers chronic kidney disease status in place of baseline creatinine.
Exploratory analyses examine patterns defined by preoperative and first 24-hour postoperative troponin measurements and their association with acute kidney injury. Because troponin and creatinine measurement windows may overlap, these analyses assess associations without assuming that troponin elevation preceded kidney injury. Additional outcomes include acute kidney injury severity, renal replacement therapy, intensive care and hospital length of stay, and intensive care and hospital mortality.
The study involves no assigned intervention or additional diagnostic testing. Registration is being completed retrospectively after data collection and analysis.
1,691 studies on the registry are indexed under Acute Kidney Injury; 395 are open to participants now.
This study's enrollment of 224 is above the median of 160 across 814 observational studies indexed under Acute Kidney Injury.
Browse Acute Kidney Injury studies →Ankara Training and Research Hospital is the lead sponsor of 48 studies on the registry; 8 are open to participants now.
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Adults aged 18 years or older who were admitted to the intensive care unit at Ankara Training and Research Hospital after emergency or elective noncardiac surgery and had preoperative troponin measurements and postoperative kidney function data available in their medical records. The retrospective cohort comprises 224 unique patients, including patients with chronic kidney disease.
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Exclusion Criteria:
Patients admitted to intensive care after emergency or elective noncardiac surgery who had preoperative troponin measurements and postoperative kidney function data available in their medical records. This retrospective cohort includes 224 patients. Patients with chronic kidney disease are included. No intervention was assigned as part of the study.
Acute Kidney Injury Within 48 Hours After Surgery
Occurrence of acute kidney injury, defined by an increase in serum creatinine of at least 0.3 mg/dL within 48 hours, an increase to at least 1.5 times the preoperative baseline within the observed 48-hour period, or initiation of renal replacement therapy. Assessment uses the serum creatinine and renal replacement therapy components of KDIGO criteria. Urine output criteria are not used because reliable retrospective data are unavailable.
Time frame: From completion of surgery through 48 hours postoperatively.
Severity of Acute Kidney Injury Within 48 Hours After Surgery
Highest acute kidney injury stage reached within the first 48 postoperative hours, classified as KDIGO stage 1, 2, or 3 using available serum creatinine measurements and renal replacement therapy data. Initiation of renal replacement therapy is classified as stage 3. Urine output criteria are not used.
Time frame: From completion of surgery through 48 hours postoperatively.
Plan to share: No — There is currently no plan to share individual participant data.
No publications or documents are linked to this record.
Ran from Jun 2024 to primary completion in Jun 2026, 24 months.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Ankara Training and Research Hospital