Drug class
Phosphodiesterase Inhibitors clinical trials
A class of medicines: the studies that test any of its 11 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones.
Keep track of what changes. Save the phosphodiesterase inhibitors studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesMedicines in this class
Studies that test each. A study of two counts under both, and once above.
Studies by the year they started
573 studies that test it; most in 2023 (47); 1 more planned to start later
| Year | Studies |
|---|---|
| 1991 | 1 |
| 1995 | 3 |
| 1996 | 1 |
| 1997 | 1 |
| 1998 | 2 |
| 1999 | 4 |
| 2000 | 5 |
| 2001 | 5 |
| 2002 | 9 |
| 2003 | 6 |
| 2004 | 5 |
| 2005 | 11 |
| 2006 | 9 |
| 2007 | 6 |
| 2008 | 11 |
| 2009 | 20 |
| 2010 | 21 |
| 2011 | 22 |
| 2012 | 23 |
| 2013 | 29 |
| 2014 | 22 |
| 2015 | 19 |
| 2016 | 25 |
| 2017 | 19 |
| 2018 | 21 |
| 2019 | 36 |
| 2020 | 29 |
| 2021 | 20 |
| 2022 | 31 |
| 2023 | 47 |
| 2024 | 35 |
| 2025 | 40 |
| 2026 | 35 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 102 · Other 481
Boehringer Ingelheim (34) · Tanta University (19) · Ain Shams University (13) · Radboud University Medical Center (9) · MediciNova (8) · University of Alcala (6) · University of California, Los Angeles (6) · Beni-Suef University (6)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten.
Testing one of them · 583
- CAffeine Use in Prolonged Oxygen Use in meConium aspIration Syndrome in Neonatal Outcomes (CAPUCINO)Not yet recruitingPhase 2University of AlbertaNCT06972108Written as Caffeine citrate
- Reverse Triple Negative Immune Resistant Breast CancerRecruitingPhase 2Fudan UniversityNCT05076682Written as Theophylline
- Oxygen Toxicity: Mechanisms in HumansRecruitingNot applicableDuke UniversityNCT05761756Written as Caffeine
- Acute Effects of Caffeine on Mitochondrial Function in Peripheral Blood Mononuclear CellsNot yet recruitingNot applicablePontificia Universidad Catolica de ChileNCT07873047Written as Caffeine (5 mg/kg)
- DDI Study of ECC0509 With Metformin, Midazolam, and CaffeineNot yet recruitingPhase 1EccogeneNCT07873229Written as Caffeine
- Pentoxifylline Add-On Therapy for Mild-to-Moderate Plaque PsoriasisNot yet recruitingNot applicableWasuchon ChaichanNCT07626788Written as Pentoxifylline 400 mg Oral Tablet
- Pentoxifylline as Anti-Inflammatory in Patients With Rheumatoid ArthritisRecruitingPhase 2Tanta UniversityNCT06998628Written as Pentoxifylline
- Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill RunRecruitingNot applicableSt. Louis UniversityNCT07854223Written as Caffeine
- Placebo Effect on Cycling Performance: Laboratory Crossover StudyNot yet recruitingNot applicablePoznan University of Physical EducationNCT07748429Written as Caffeine (6mg/kg)
- Improving Preterm Kidney Outcomes With CaffeineRecruitingPhase 2University of Wisconsin, MadisonNCT07262060Written as Caffeine citrate
- Intravenous Papaverine for Term Prelabor Rupture of MembranesRecruitingNot applicableWolfson Medical CenterNCT07826533Written as Papaverine
- Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)RecruitingPhase 2M.D. Anderson Cancer CenterNCT06494111Written as Pentoxifylline
- TCP-600 Supplementation and Performance Response in Professional Football PlayersRecruitingNot applicableVizja University in WarsawNCT07710547Written as Caffeine
- Theophylline for Treatment of PseudohypoparathyroidismEnrolling by invitationPhase 2Jaclyn TamaroffNCT04240821Written as Theophylline ER
- Predicting Response and Exposure Changes in Cirrhosis for EffectivenessNot yet recruitingNot applicableAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)NCT07750587Written as Five-Drug CYP Probe Cocktail
- The Effects of Acute Nitrate and Caffeine Co-ingestion on Discipline-Specific Exercise Performance.Not yet recruitingNot applicablePoznan University of Physical EducationNCT07748416Written as Caffeine
- Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing ChemoradiationRecruitingPhase 2University Health Network, TorontoNCT06634056Written as Pentoxifylline
- Placebo Effect in Field-Based Physical PerformanceNot yet recruitingNot applicablePoznan University of Physical EducationNCT07742150Written as Caffeine (6mg/kg)
- Dipyridamole for Early-Onset Preeclampsia: A Pilot Study of Feasibility, Pharmacokinetics, and Biological EffectsNot yet recruitingPhase 1/2Hadassah Medical OrganizationNCT07738562Written as Dipyridamole 75 MG
- Caffeine Optimization for Oxygen Saturation Index in ELBW InfantsRecruitingPhase 2University of RochesterNCT07216365Written as Caffeine Citrate
See all 583 studies that test one of the phosphodiesterase inhibitors →