A Phase 2 interventional study of Letrozole 2.5mg and Placebo in Miscarriage and Missed Abortion, sponsored by Ain Shams Maternity Hospital. Status unknown at 1 site in Egypt. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-10-09.
Sponsored by Ain Shams Maternity Hospital · Phase 2, Interventional, and Treatment
Among 12 studies in Abortion, Missed with a site in Egypt — none open to participants now, none under way, none of them phase 3. Abortion, Missed · Egypt.
Among the 12 studies in Abortion, Missed with a site in Egypt, this one is the 8th largest by planned enrollment of the 11 interventional ones, is one of 2 that started in 2018, is one of 3 in phase 2, and was the 5th registered.
48 studies on the registry are indexed under Abortion, Missed; 10 are open to participants now.
This study's planned enrollment of 80 is below the median of 110 across 41 interventional studies indexed under Abortion, Missed.
Browse Abortion, Missed studies →None of the 12 studies in Abortion, Missed with a site in Egypt is open now.
Of the 5 Abortion, Missed studies recruiting now, 0 (0%) set no upper age limit and 5 (100%) stop at 75 or younger; 0 take children under 18; 1 take healthy volunteers.
This study: 18 Years and older · female · healthy volunteers too.
The full table on the hub →12 studies; the count open now beside each. This study's row is marked.
First in 2015; this study’s year is marked. 2 started in 2018.
Median enrollment 140 across the 11 interventional studies, 320 across the 1 observational. Of the 5 that completed or were terminated, 0 (0%) have results posted.
None of the 12 has an industry lead sponsor. The 7 most frequent:
Ain Shams Maternity Hospital is the lead sponsor of 139 studies on the registry; 8 are open to participants now.
Ain Shams Maternity Hospital has 1 study filed under Abortion, Missed — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 12 studies in Abortion, Missed with a site in Egypt, from their registry updates:
Nothing recorded among them since 2026-09-25.
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.
According to the American college of obstetricians and gynecologists (2005), medical abortion is an acceptable alternative for surgical procedures in pregnant women with gestational age of less than 49 days based on the last menstrual period
Oral or vaginal misoprostol causes complete abortion in almost 85% of cases within seven days before the 12th week
letrozole administration with misoprostol raises the rate of complete abortion
Hypothesis:
In women with missed miscarriage in the first trimester undergoing induction of abortion pre-treatment with letrozole before misoprostol may lead to abortion rate similar to misoprostol alone.
48 studies on the registry are indexed under Abortion, Missed; 10 are open to participants now.
This study's planned enrollment of 80 is below the median of 110 across 41 interventional studies indexed under Abortion, Missed.
Browse Abortion, Missed studies →Ain Shams Maternity Hospital is the lead sponsor of 139 studies on the registry; 8 are open to participants now.
Compared within Abortion, Missed, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Abortion, Spontaneous. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The protein in red blood cells that carries oxygen. A low level is anaemia, which can cause tiredness and breathlessness. Measured in g/dL or g/L (9 g/dL is 90 g/L).
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Hemoglobin (Hb)
The protein in red blood cells that carries oxygen. A low level is anaemia, which can cause tiredness and breathlessness. Measured in g/dL or g/L (9 g/dL is 90 g/L).
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
3 tablets of Letrozole 2.5 mg will be given as single daily dose, 7.5 mg per day for two days at home and the third dose will be given on admission to hospital on day 3 and will be followed by vaginal misoprostol 800 mcg every three hours up to maximum two doses.
Drug: Letrozole 2.5mg · Drug: Misoprostol
three tablets of placebo will be given as a single daily dose, for two days at home and will be admitted on day 3 and continue treatment with misoprostol 800 mcg every three hours up to maximum two doses
Drug: Placebo · Drug: Misoprostol
total dose 7.5 mg per day for 3 days
Folic acid for 3 days
Misoprosrol 800mcg will be given to all patients for induction of abortion
Incidence of complete miscarriage
Time frame: 6 hours
Need for surgical evacuation of the products of conception
Time frame: 6 hours
Incidence of Septic Abortion
Time frame: 1 week
Started Sep 2018 (actual). Primary completion is estimated for Dec 2018, 2 months after the start.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Letrozole
Ain Shams Maternity Hospital →