Drug
Letrozole clinical trials
Also written Femara, CGS 20267 and FEM345.
- studies test it
- 366
- open now
- 56
- in phase 3
- 85
- first study started
- 1998
Keep track of what changes. Save the Letrozole studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
366 studies that test it; most in 2022 (24)
| Year | Studies |
|---|---|
| 1998 | 2 |
| 1999 | 1 |
| 2000 | 6 |
| 2001 | 2 |
| 2002 | 6 |
| 2003 | 9 |
| 2004 | 11 |
| 2005 | 15 |
| 2006 | 12 |
| 2007 | 13 |
| 2008 | 18 |
| 2009 | 14 |
| 2010 | 11 |
| 2011 | 6 |
| 2012 | 13 |
| 2013 | 10 |
| 2014 | 8 |
| 2015 | 17 |
| 2016 | 23 |
| 2017 | 15 |
| 2018 | 18 |
| 2019 | 17 |
| 2020 | 19 |
| 2021 | 16 |
| 2022 | 24 |
| 2023 | 21 |
| 2024 | 14 |
| 2025 | 12 |
| 2026 | 13 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 10
- Phase 1
- 49
- Phase 2
- 164
- Phase 3
- 85
- Phase 4
- 45
- No phase
- 50
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 72 · Other 294
Novartis Pharmaceuticals (28) · M.D. Anderson Cancer Center (8) · Dana-Farber Cancer Institute (8) · Cairo University (8) · Assiut University (8) · University of California, San Francisco (6) · The University of Hong Kong (6) · Fudan University (5)
Often tested with
Tested in the same studies.
Anastrozole (24) · Palbociclib (23) · Tamoxifen (23) · Exemestane (20) · Fulvestrant (17) · Everolimus (14) · Trastuzumab (14) · Abemaciclib (13)
Studies
Open first, then newest update. How each study uses Letrozole is read from its arms, and is right about nine times in ten.
Testing it · 366
- Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have Completed the OVELIA StudyEnrolling by invitationPhase 3Tolmar Inc.NCT05645536Written as Letrozole tablets
- A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian CancerRecruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT06394804Written as Letrozole
- ALPINE: Maintenance Letrozole/AbemaciclibRecruitingPhase 2Dana-Farber Cancer InstituteNCT06366347Written as Letrozole
- A Study to Evaluate the Effects of GDC-4198 in Combination With Letrozole, Fulvestrant, or Giredestrant in Participants With Locally Advanced or Metastatic Hormone Receptor-Positive, HER2-Negatve Breast CancerNot yet recruitingPhase 1Genentech, Inc.NCT07867262Written as Letrozole
- Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)RecruitingPhase 3Celcuity IncNCT06757634Written as Arm C: Gedatolisib + Palbociclib + Letrozole
- A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast CancerRecruitingPhase 1/2Hoffmann-La RocheNCT03424005Written as Letrozole
- De-EscaLaTion of Aromatase Inhibitor Therapy: A Randomized Phase II Study of De-escalated Letrozole in Hormone Receptor-Positive Early Breast CancerNot yet recruitingPhase 2Montefiore Medical CenterNCT07866430Written as Letrozole
- Prescription of Letrozole for Uterine MyomaRecruitingPhase 4University of California, San FranciscoNCT06143631Written as Letrozole 2.5mg
- A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)RecruitingPhase 2Merck Sharp & Dohme LLCNCT06979596Written as Letrozole
- FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural CyclesRecruitingNot applicableUniversity of Novi SadNCT07425990Written as Letrozole (Aromatase Inhibitors)
- A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of RecurrenceRecruitingPhase 3Stemline Therapeutics, Inc.NCT06492616Written as Letrozole
- GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia PatientsRecruitingPhase 2/3Xiaojun ChenNCT05316935Written as Letrozole 2.5mg
- GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer PatientsRecruitingPhase 2/3Xiaojun ChenNCT06379113Written as Letrozole 2.5mg
- Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast CancerRecruitingPhase 3AstraZenecaNCT06380751Written as Letrozole
- Culmerciclib Combined With Letrozole and Dual HER2 Blockade as Neoadjuvant Therapy for HR+/HER2+ Breast CancerNot yet recruitingPhase 2Shengjing HospitalNCT07795424Written as Letrozole
- Letrozole in Uterine LeiomyosarcomaRecruitingPhase 2GOG FoundationNCT05649956Written as Letrozole
- Kumorixilib Plus Capecitabine and Letrozole for Neoadjuvant Treatment of HR-Positive HER2-Negative Breast CancerNot yet recruitingPhase 2Fujian Cancer HospitalNCT07691333Written as Letrozole 2.5mg
- Clinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA TrialNot yet recruitingPhase 2Universitaire Ziekenhuizen KU LeuvenNCT07676331Written as Letrozole (Aromatase Inhibitors)
- RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial CancerRecruitingPhase 2Dana-Farber Cancer InstituteNCT03675893Written as Letrozole
- Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors TrialRecruitingPhase 3University of California, San FranciscoNCT03011684Written as Letrozole
See all 366 studies that test Letrozole →
Given in every arm · 157 — Letrozole is usual care beside what is tested
- Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low TrialRecruitingPhase 3National Cancer Institute (NCI)NCT07391774Written as Letrozole
- Study of PF-07248144 in Advanced or Metastatic Solid TumorsRecruitingPhase 2PfizerNCT04606446Written as Letrozole
- Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid TumorsRecruitingPhase 1/2PfizerNCT04557449Written as Letrozole
- Study of IEV407 as Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast CancerRecruitingPhase 1Novartis PharmaceuticalsNCT07604571Written as Letrozole
- BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic DiseaseRecruitingPhase 3BeOne MedicinesNCT07492641Written as Letrozole
- BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid TumorsRecruitingPhase 1BeOne MedicinesNCT06120283Written as Letrozole
- Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid TumorsRecruitingPhase 1/2Novartis PharmaceuticalsNCT07288359Written as Letrozole
- A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)RecruitingPhase 3Eli Lilly and CompanyNCT07174336Written as Letrozole
- A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast CancerRecruitingPhase 3Hoffmann-La RocheNCT06790693Written as Letrozole
- Study of AVZO-021 in Patients With Advanced Solid TumorsRecruitingPhase 1/2Avenzo Therapeutics, Inc.NCT05867251Written as Letrozole
- A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast CancerRecruitingPhase 2Hoffmann-La RocheNCT07054190Written as Letrozole
- Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast CancerRecruitingPhase 2University of WashingtonNCT06179303Written as Letrozole
- Roll-Over Study of Alpelisib (BYL719) for Continued Access and Long-Term Safety.Not yet recruitingPhase 2Novartis PharmaceuticalsNCT07679269Written as Letrozole
- Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast CancersRecruitingPhase 2Ruth O'ReganNCT04886531Written as Letrozole (L) or Anastrozole (A)
- A Study With NKT5097 for Adults With Advanced/Metastatic Solid TumorsRecruitingPhase 1NiKang Therapeutics, Inc.NCT07029399Written as Letrozole
- A Phase 2 Single-Arm Open-Label Pilot Trial Evaluating Zanidatamab (ZW25) in Patients With Early Stage HER2/Neu Positive (HER2+) Breast Cancer (BC)RecruitingPhase 2M.D. Anderson Cancer CenterNCT05035836Written as Letrozole
- Study of Letrozole in Recurrent GliomasRecruitingEarly Phase 1University of CincinnatiNCT03122197Written as Letrozole Oral Tablet
- ORION-1: Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid TumorsRecruitingPhase 1/2Avenzo Therapeutics, Inc.NCT06998407Written as Letrozole
- Fulvestaciclib Combined With Anti-HER2 and Endocrine Therapy for HR+/HER2+ Advanced Breast CancerNot yet recruitingPhase 2Fudan UniversityNCT07716046Written as Letrozole
- Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast CancerRecruitingEarly Phase 1Emory UniversityNCT05464810Written as Letrozole
Showing 20 of 157.
As the comparator · 41 — what is tested is compared with Letrozole
- A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine TherapyRecruitingPhase 3AstraZenecaNCT05774951Written as Letrozole
- A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian CancerRecruitingPhase 3Verastem, Inc.NCT06072781Written as Letrozole
- Elacestrant for Treating ER+/HER2- Breast Cancer Patients With ctDNA Relapse (TREAT ctDNA)RecruitingPhase 3European Organisation for Research and Treatment of Cancer - EORTCNCT05512364Written as Letrozole 2.5mg
- A Phase 3 Study of HRS-8080 Versus Treatment Chosen by Physicians in Locally Advanced and Metastatic Breast CancerRecruitingPhase 3Shandong Suncadia Medicine Co., Ltd.NCT07024173Written as Letrozole Tablets
- DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as TreatmentRecruitingPhase 2QuantumLeap Healthcare CollaborativeNCT06075953Written as Letrozole
- Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast CancerRecruitingPhase 3Olema Pharmaceuticals, Inc.NCT07085767Written as Letrozole
- Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After LumpectomyRecruitingPhase 2UNC Lineberger Comprehensive Cancer CenterNCT05472792Written as tamoxifen, anastrozole, exemestane, letrozole, fulvestrant, toremifene
- A Phase III Trial Comparing HRS-8080 With Standard Endocrine Therapy in Patients With Intermediate or High Risk Early Breast CancerRecruitingPhase 3Shandong Suncadia Medicine Co., Ltd.NCT07349069Written as Letrozole tablets
- Cabergoline & Letrozole Versus Letrozole in Ovulation Induction in PCOSRecruitingNot applicableMst.Sumyara KhatunNCT07255911Written as Letrozole 0.5mg
- Adjuvant Abemaciclib for Locoregional Recurrence of HR-positive, HER2-negative Breast Cancer (JCOG2313, AURA)RecruitingPhase 3Japanese Foundation for Cancer ResearchNCT07190443Written as Endocrine Therapy (ET): letrozole, anastrozole, exemestane, tamoxifen
- Trastuzumab Deruxtecan Versus Standard Neoadjuvant Treatment for HER2-positive Breast CancerRecruitingPhase 2Karolinska University HospitalNCT05900206Written as Letrozole
- A Trial of Early Detection of Molecular Relapse With Circulating Tumour DNA Tracking and Treatment With Palbociclib Plus Fulvestrant Versus Standard Endocrine Therapy in Patients With ER Positive HER2 Negative Breast CancerRecruitingPhase 2Royal Marsden NHS Foundation TrustNCT04985266Written as Letrozole
- Tailoring NEOadjuvant Therapy in Hormone Receptor Positive, HER2 Negative, Luminal Breast Cancer.Active, not recruitingPhase 2Borstkanker Onderzoek GroepNCT03283384Written as Letrozole
- Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)Active, not recruitingPhase 3AstraZenecaNCT04964934Written as Letrozole
- Study for Participants Continuing From Pfizer-sponsored Palbociclib (a Study Medicine) StudiesActive, not recruitingPhase 2PfizerNCT05226871Written as Letrozole
- Testing Low Dose Tamoxifen for Invasive Breast Cancer, LoTam TrialSuspendedPhase 3Alliance for Clinical Trials in OncologyNCT06671912Written as Letrozole
- A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)Active, not recruitingPhase 3Hoffmann-La RocheNCT04546009Written as Letrozole
- Magnesium Oxide and Letrozole Versus Letrozole Alone on Ovarian Response in Insulin Resistant PCOSCompletedNot applicableBangladesh Medical UniversityNCT07766590Written as Letrozole 2.5mg
- OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast CancerActive, not recruitingPhase 3Olema Pharmaceuticals, Inc.NCT06016738Written as Letrozole
- An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)Active, not recruitingPhase 3AstraZenecaNCT05952557Written as Letrozole
Showing 20 of 41.
Codes
What other systems call Letrozole · ClinicalTrials.gg INT006690
- MeSH (NLM) D000077289LetrozoleConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 7LKK855W8ILETROZOLEConfirmed FDA, NLM, Wikidata
- RxNorm 72965Confirmed FDA, Wikidata
- Wikidata Q194974letrozoleConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C1527LetrozoleOne source FDA
- DrugBank DB01006One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000077289 | Letrozole | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 7LKK855W8I | LETROZOLE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 72965 | — | Confirmed FDA, Wikidata |
| Wikidata | Q194974 | letrozole | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C1527 | Letrozole | One source FDA |
| DrugBank | DB01006 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.