An observational study in Intrapartum Fetal Distress, sponsored by Ain Shams Maternity Hospital. Not yet recruiting. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-10-19.
Sponsored by Ain Shams Maternity Hospital · Observational
Each fetus has a different metabolic capacity at the onset of labor, and in cases of an imbalance between fetal demands and placental oxygen supply, fetal hypoxia occurs. In this scenario, and to avoid permanent fetal damage, a cesarean section (CS) for intrapartum fetal compromise (IFC) might be needed to minimize the potential consequences of sustained hypoxia.
Acute fetal compromise is one of the leading causes of perinatal morbidity and mortality worldwide. As well as being a major cause of fetal death, a reduction in the oxygen supply for the conceptus can lead to relevant neonatal complications. Intrapartum fetal compromise (IFC) occurs in a significant proportion (10-15%) of cases of intrapartum hypoxia-ischemia. In most cases, Intra-partum fetal compromise occurs in low-risk pregnancies, making adverse perinatal outcomes difficult to predict.
The placenta is the organ in charge of supplying the fetus with enough nutrition to allow its appropriate growth during pregnancy, and it also copes with different hypoxic insults. Labor is a physiological but stressful situation for the fetus and the mother, characterized by repeated transient episodes of uterine contractions, causing fetal intermittent hypoxia. Each uterine contraction is associated with an increase in intrauterine pressure by 25 to 70 mmHg, resulting in a 25% drop in the partial pressure of oxygen at the fetal side.
Cerebroplacental ratio is widely used to diagnose adverse perinatal outcomes as it assesses the correlation between fetal cerebral redistribution and hypoxemia, which is independent of birth weight.This, has consequences for assessing the well-being of small for gestational age(SGA) and appropriate for gestational age(AGA) fetuses close to the end of pregnancy.
A key clinical goal before labour onset is to predict fetal intolerance to labour, intrapartum fetal compromise from hypoxia, emergency caesarean delivery, and subsequent serious perinatal morbidity and mortality.
When the fetus suffers hypoxia, one of its multiple adaptive mechanisms is the centralization of blood flow to the most noble organs, such as the fetal brain. This situation can be evaluated with Doppler ultrasound measuring the cerebro-placental ratio (CPR), Calculated by dividing the Doppler flow rate of the middle cerebral artery (MCA) by the flow rate of the umbilical artery (UA). the CPR is an obstetric US measurement that demonstrates how elevated placental resistance and fetal hypoxia lead to the redistribution of cardiac output to the cerebral circulation.
The cerebroplacental ratio evaluation is used to detect and assess the fetal response to oxygen defciency in utero. With the progress of pregnancy, the resistance in fetal circulation decreases gradually. Nevertheless, the values of middle cerebral artery pulsatility index (MCA PI) should remain higher than umbilical artery pulsatility index (UA PI) values, which implicates that CPR, being the ratio of (MCA PI) to (UA PI), should be higher than 1 in uncomplicated pregnancies.
Ain Shams Maternity Hospital is the lead sponsor of 139 studies on the registry; 8 are open to participants now.
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Pregnant women scheduled for elective induction of labour at term.
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Exclusion Criteria:
Intrapartum fetal distress
Intrapartum fetal compromise requiring operative delivery (instrumental vaginal delivery or cesarean section)
Time frame: At delivery
No study locations are listed for this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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