An observational study in Monochorionic Twins and Cerebroplacental Ratio, sponsored by Ain Shams Maternity Hospital. Recruiting at 1 site in Egypt. Open to female participants. Per ClinicalTrials.gov, last updated 2025-09-05.
Sponsored by Ain Shams Maternity Hospital · Observational
The purpose of this study is to evaluate the predictive value of CPR discordance at 16-20 weeks in MCDA twin pregnancies in predicting monochorionic-specific complications such as TTTS, TAPS, sFGR and IUFD of one or both fetuses
Monochorionic (MC) twin pregnancies are at a higher risk of perinatal morbidity and mortality because of the risk of developing unique complications. These include twin to twin transfusion syndrome (TTTS), selective fetal growth restriction (sFGR) , twin anemia polycythemia sequence (TAPS) and intrauterine fetal death (IUFD) of one or both fetuses. Therefore, early identification of these conditions is warranted to plan proper perinatal surveillance and management to improve outcome.
Sparse studies have found that inter-twin differences in Doppler ultrasound may occur prior to meeting diagnostic criteria for TTTS, TAPS, sFGR or adverse perinatal outcomes.
This study will try to reveal the potential clinical predictive value of inter-twin cerebroplacental ratio (CPR) discordance in the surveillance of MC twin pregnancies.
Ain Shams Maternity Hospital is the lead sponsor of 139 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Monochorionic diamniotic twin pregnancies with discordant cerebroplacental ratio at 16-20 weeks of gestation presenting to Ain Shams University Maternity Hospital for antenatal care.
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Exclusion Criteria:
Measuring cerebroplacental ratio discordance in monochorionic twins at 16-20 Weeks of gestation
Development of monochorionic specific complications
Monochorionic specific complications include twin to twin transfusion syndrome, twin anemia polycythemia sequence and selective fetal growth restriction
Time frame: From 16-20 weeks of gestation till delivery.
Occurrence of intrauterine fetal death or perinatal mortality of one or both fetuses
Gestational age upon occurrence of IUFD with clarifying if complications occur in the surviving twin in case of single fetal demise. Time and reason of perinatal mortality for any of the fetuses Wil be recorded.
Time frame: From 16-20 weeks of gestation till 7th day of life
Plan to share: Yes — Name and email address
Supporting information: Study protocol
Time frame: From 2025 till 2028
Access criteria: Any researcher, physician or university lecturer Access for full study content
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